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9 条记录 (耗时 0.045 秒)

    Transdermal absorption preparation
    1.
    发明授权
    Transdermal absorption preparation 失效
    透皮吸收制剂

    公开(公告)号：US5723145A

    公开(公告)日：1998-03-03

    申请号：US898646

    申请日：1997-07-22

    申请人： Yasuo Shikinami ,  Kunihiro Hata ,  Seiei Sasatani ,  Masao Sudoh

    发明人： Yasuo Shikinami ,  Kunihiro Hata ,  Seiei Sasatani ,  Masao Sudoh

    IPC分类号： A61K9/70 ,  A61F13/02

    CPC分类号： A61K9/7084

    摘要： The present invention provides a transdermal absorption preparation whereby a drug, which takes effect with a small amount, and is liable to be decomposed, solid at ordinary temperatures, water-soluble and less absorbable into the skin, can be stored stably for a long period of time and, can be transdermally administered at a high releasing ratio and yet releasing slowly, when applied to the skin. The constitution of the present invention is as follows: a transdermal absorption preparation which comprises a drug-storing layer containing a drug and having a drug-releasing face coated with a drug-releasing controlling membrane, wherein said drug-storing layer comprises as a base a heat-sensitive segmented polyurethane represented by the general formula: R--A--(U)--F--(U)--B--R' wherein A and B each represents a polymer of ethylene oxide, propylene oxide, tetramethylene oxide or 1,2-butylene oxide, or a random or block copolymer thereof, R and R' each represents a terminal H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7 or C.sub.4 H.sub.9, A=B or A.noteq.B, R=R' or R.noteq.R', F represents a constituting structure which is a moiety of a diisocyanate compound excluding two isocyanate groups, and (U) represents a urethane bond, and at least one of A and B is hydrophilic and at the same time at least one of A and B has a characteristic that it melts near the temperature of human skin, and wherein said drug-releasing controlling membrane is a phase-separated membrane comprising a mixture of a crosslinked gelatin phase and the uncrosslinked segmented polyurethane phase.

    摘要翻译： 本发明提供一种经皮吸收制剂，其可以稳定地长时间保存少量效果易于分解的药物，常温下为固体，易溶于水并且难以吸收到皮肤中的药物 的时间，并且可以以高释放比透皮施用，并且当施用于皮肤时缓慢释放。 本发明的构成如下：一种透皮吸收制剂，其包含含有药物的药物储藏层，并且具有涂敷有药物释放控制膜的药物释放面，其中所述药物储存层包含作为碱 由通式为RA-（U）-F-（U）-B-R'表示的热敏分段聚氨酯，A和B各自表示环氧乙烷，环氧丙烷，四氢呋喃或1,2-二氧化碳的聚合物， 环氧丁烷或其无规或嵌段共聚物，R和R'各自表示H，CH 3，C 2 H 5，C 3 H 7或C 4 H 9的末端，A = B或A，等式B，R = R'或R， 构成结构，除二异氰酸酯基以外的二异氰酸酯化合物的部分，（U）表示氨基甲酸酯键，A和B中的至少一个为亲水性，同时A和B中的至少一个具有以下特征： 它在人的皮肤温度附近熔化，并且其中所述药物释放控制 纳米膜是相分离膜，其包含交联明胶相和未交联的分段聚氨酯相的混合物。

    Radiation process for producing 1,2-polybutadiene foamed products
    3.
    发明授权
    Radiation process for producing 1,2-polybutadiene foamed products 失效
    用于生产1,2-聚丁二烯发泡产品的辐射工艺

    公开(公告)号：US4144153A

    公开(公告)日：1979-03-13

    申请号：US728653

    申请日：1976-10-01

    申请人： Yasuo Shikinami ,  Ryuichi Kimura ,  Yoshinobu Yoshikawa ,  Kosuke Iida ,  Kunihiro Hata

    发明人： Yasuo Shikinami ,  Ryuichi Kimura ,  Yoshinobu Yoshikawa ,  Kosuke Iida ,  Kunihiro Hata

    IPC分类号： C08F2/46 ,  C08J9/00

    CPC分类号： C08J9/0023 ,  C08J2309/00 ,  Y10S260/43 ,  Y10S521/915 ,  Y10S521/916

    摘要： A process for producing a photodegradable rubber foamed products of excellent softness, which comprises mixing 1,2-polybutadiene with 0.1 to 3.0% of a photosensitizer and with a thermally decomposable foaming agent, irradiating with ultraviolet ray of a wavelength of 240 to 400 m.mu. for 10 minutes or less to form a cross-linked material having a gel fraction of 30 to 80% (in boiling toluene; 7 hours), and heating to 150 to 230.degree. C. to form a foamed product. In particularly preferred embodiments of this invention, the foaming agent is p,p'-oxybis (benzenesulfonylhydrazide).

    摘要翻译： 一种柔软性优异的可光降解橡胶发泡体的制造方法，其特征在于，将1,2-聚丁二烯与0.1〜3.0％的光敏剂和热分解性发泡剂混合，照射波长为240〜400μm的紫外线 10分钟以下，形成凝胶分数为30〜80％（沸腾甲苯; 7小时）的交联材料，加热至150〜230℃，形成发泡体。 在本发明的特别优选的实施方案中，发泡剂是p，p'-氧双（苯磺酰肼）。

    Pressure sensitive adhesive for transdermal absorption formulations
    4.
    发明授权
    Pressure sensitive adhesive for transdermal absorption formulations 失效
    用于透皮吸收制剂的压敏粘合剂

    公开(公告)号：US5773490A

    公开(公告)日：1998-06-30

    申请号：US605584

    申请日：1996-02-22

    申请人： Yasuo Shikinami ,  Kunihiro Hata

    发明人： Yasuo Shikinami ,  Kunihiro Hata

    IPC分类号： C08G18/48 ,  C09J4/00 ,  C08J3/00 ,  C08K3/20 ,  C08L75/00

    CPC分类号： C08G18/4837 ,  C08G18/4841 ,  C08G2170/40

    摘要： Pressure sensitive adhesives for transdermal absorption formulations comprising a segmented polyurethane, which can control dissolution and a releasing property of drugs of various kinds which are solid at normal temperature; said segment being an alkylene oxide chain which is in a liquid state at a temperature of around normal temperature to around body temperature, and said segment containing a hydrophilic alkylene oxide chain and a hydrophobic alkylene oxide chain, or comprising one or both of them and an alkylene oxide chain in which a hydrophilic moiety and a hydrophobic moiety are present in the mixed manner.

    摘要翻译： 用于经皮吸收制剂的压敏粘合剂，其包含分段聚氨酯，其可以控制在常温下为固体的各种药物的溶解和释放性质; 所述链段是在常温至大约体温的温度下为液态的环氧烷链，并且所述链段含有亲水性烯化氧链和疏水环氧烷链，或者包含它们中的一种或两者，和 其中亲水部分和疏水部分以混合方式存在的氧化烯链。

    Insect repellent material containing amide ingredient, chlorinated polyethylene and elastomer
    5.
    发明授权
    Insect repellent material containing amide ingredient, chlorinated polyethylene and elastomer 失效
    含有酰胺成分，氯化聚乙烯和弹性体的驱虫剂

    公开(公告)号：US4981689A

    公开(公告)日：1991-01-01

    申请号：US532125

    申请日：1990-06-01

    申请人： Yasuo Shikinami ,  Kunihiro Hata ,  Hiroshi Kimura ,  Kiyoshi Utsumi

    发明人： Yasuo Shikinami ,  Kunihiro Hata ,  Hiroshi Kimura ,  Kiyoshi Utsumi

    IPC分类号： A01N25/10 ,  A01N25/18

    CPC分类号： A01N25/10 ,  A01N25/18

    摘要： This invention relates to a repellent material comprising an amide type repelling ingredient, a chlorinated polyethylene and a thermoplastic elastomer, and more particularly to an insect repellent material for preventing insects such as flies, mites, cockroaches and other insects from invading into electronic balances, telephones, computers, facsimiles, automatic vending machines and others in kitchens, foodshops, food storages, foodfirms, or offices, clean rooms, which has an excellent repelling effect to the insects, the repelling effect being controllable for a long period of time in view of using aims.

    摘要翻译： 本发明涉及包含酰胺型排斥成分，氯化聚乙烯和热塑性弹性体的驱避剂材料，更具体地说，涉及防止诸如苍蝇，螨虫，蟑螂和其他昆虫等昆虫入侵电子天平，电话机的驱虫剂 ，电脑，传真机，自动售货机等，在厨房，食品店，食品店，食品店或办公室，洁净室，对昆虫具有极佳的排斥作用，排斥效果可长期控制，鉴于 使用目标。