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1.发明申请ANTI-POLYETHYLENE GLYCOL ANTIBODY EXPRESSING CELL QUANTIFY ANY FREE POLYETHYLENE GLYCOL AND POLYETHYLENE GLYCOL-DERIVATIZED MOLECULES 审中-公开抗聚乙二醇抗体表达细胞定量任意的聚乙烯甘油和聚乙二醇衍生的分子公开(公告)号：US20120015380A1
公开(公告)日：2012-01-19
申请号：US13032317
申请日：2011-02-22
Applicant: Tian-Lu Cheng , Steven R. Roffler , Kuo-Hsiang Chuang , Ssu-Jung Lu
Inventor： Tian-Lu Cheng , Steven R. Roffler , Kuo-Hsiang Chuang , Ssu-Jung Lu
CPC classification number: G01N33/94 , C07K16/44 , C12N2503/02 , G01N33/5308 , G01N33/9493
Abstract: In this invention, anti-PEG antibodies or anti-methoxyl-PEG (anti-CH3O-PEG) antibodies were expressed on cell surface which can collocate with a biotinylated anti-PEG antibody (AGP4-Biotin) or biotinylated PEG (PEG-Biotin) to develop a cell-based sandwich ELISA or a cell-based competition ELISA, respectively. Both of these two methods could sensitively quantify free PEG and PEG-modified macromolecules (proteins, nanoparticles and liposomes) as sensitive as nano-gram level.
Abstract translation: 在本发明中，在可以与生物素化的抗-PEG抗体（AGP4-生物素）或生物素化PEG（PEG-生物素））配位的细胞表面上表达抗-PEG抗体或抗甲氧基-PEG（抗-CH 3 O-PEG） 分别开发基于细胞的夹心ELISA或基于细胞的竞争ELISA。 这两种方法都可以敏感地将游离的PEG和PEG修饰的大分子（蛋白质，纳米颗粒和脂质体）定量为纳克级。
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2.发明申请RECOMBINANT NUCLEOTIDE SEQUENCE, CELL OR VECTOR CONTAINING THE SAME AND METHOD FOR USING CELL CONTAINING THE SAME TO ENCODE ANTI-POLYETHYLENE GLYCOL MONOCLONAL ANTIBODIES 有权重组核酸序列，含有该重组核苷酸序列的细胞或载体以及使用含有其的细胞编码抗聚乙二醇单克隆抗体的方法公开(公告)号：US20110064651A1
公开(公告)日：2011-03-17
申请号：US12766930
申请日：2010-04-26
Applicant: Tian-Lu Cheng , Steve R. Roffler , Kuo-Hsiang Chuang
Inventor： Tian-Lu Cheng , Steve R. Roffler , Kuo-Hsiang Chuang
CPC classification number: A61K49/0054 , A61K49/0019 , A61K49/0032 , A61K49/186 , A61K51/065 , B82Y5/00
Abstract: The invention provides a recombinant nucleotide sequence, including the sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 or SEQ ID No. 4, wherein the recombinant nucleotide sequence encodes an anti-polyethylene glycol recombinant single chain membrane antibody.
Abstract translation: 本发明提供重组核苷酸序列，其包括SEQ ID No.1，SEQ ID No.2，SEQ ID No.3或SEQ ID No.4的序列，其中重组核苷酸序列编码抗聚乙二醇重组单链 膜抗体。
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3.发明授权Recombinant nucleotide sequence, cell or vector containing the same and method for using cell containing the same to encode anti-polyethylene glycol monoclonal antibodies 有权重组核苷酸序列，含有该重组核苷酸序列的细胞或载体以及使用含有该重组核苷酸序列的细胞编码抗聚乙二醇单克隆抗体的方法公开(公告)号：US08507207B2
公开(公告)日：2013-08-13
申请号：US12766930
申请日：2010-04-26
Applicant: Tian-Lu Cheng , Steve R. Roffler , Kuo-Hsiang Chuang
Inventor： Tian-Lu Cheng , Steve R. Roffler , Kuo-Hsiang Chuang
CPC classification number: A61K49/0054 , A61K49/0019 , A61K49/0032 , A61K49/186 , A61K51/065 , B82Y5/00
Abstract: The invention provides a recombinant nucleotide sequence, including the sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 or SEQ ID No. 4, wherein the recombinant nucleotide sequence encodes an anti-polyethylene glycol recombinant single chain membrane antibody.
Abstract translation: 本发明提供重组核苷酸序列，其包括SEQ ID No.1，SEQ ID No.2，SEQ ID No.3或SEQ ID No.4的序列，其中重组核苷酸序列编码抗聚乙二醇重组单链 膜抗体。
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