摘要:
There is provided a method of preparing biodegradable dual pore polymer scaffolds, comprising the steps of: maintaining a polymer solution containing a biodegradable polymer, an effervescent mixture of carbonate and organic acid, and solvent at a temperature range of −196° C. to ambient temperature so as to evaporate the solvent and produce a polymer sample; and foaming the polymer sample in a mixed solution of water and alcohol. According to the present invention, the pore size of the polymer scaffolds can be easily controlled, and biodegradable polymer scaffolds can be more simply prepared compared to conventional methods such as salt leaching technique, phase separation technique or gas foaming technique. Further, since the biodegradable polymer scaffolds prepared according to the present invention have a high surface area and porosity without formation of skin layer, secretion of toxic substances and remnant phenomenon, they can be advantageously used for regenerating almost all living tissues and organs in tissue engineering.
摘要:
A circuit module for a silicon condenser microphone of the present disclosure includes a transducer, a charge pump, an isolator, a first amplifier, a second amplifier, a reaction circuit, a first bias circuit, and a second bias circuit. The charge pump electrically connects to an input port of the transducer, and an output port of the transducer electrically connects to an input port of the first amplifier via the isolator. An output port of the first amplifier electrically connects to an input port of the second amplifier. The reaction circuit is arranged between the output port of the first amplifier and the input port of the transducer. The isolator isolates the direct-current components of the first electrical signal, and therefore, the oscillations of the direct-current components will not affect the performance of the first amplifier.
摘要:
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要:
The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.
摘要:
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要:
The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.
摘要:
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要:
Disclosed herein a pharmaceutical composition, comprising obovatol as an active ingredient, for the prevention and treatment of neurodegenerative diseases. Having superior inhibitory activity against the production of neurotoxic nitric oxides, the obovatol isolated and purified from Magnoliaceae can be used as active ingredient for a pharmaceutical composition or a neuroprotective agent for the prevention and treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
摘要:
An apparatus and system are described for measurement and reporting of Channel State Information (CSI) prediction performance. A user equipment (UE) receives Channel State Information (CSI) Reference Signals (CSI-RS) from a 5th generation NodeB (gNB) at different time instances and performs perform channel measurements on the CSI-RS. The UE calculates a predicted CSI for a later time instance based on the CSI-RS and subsequently performs a channel measurement based on a CSI-RS received in the later time instance. The UE calculates an actual CSI based on the CSI-RS received in the later time instance. determines metrics based on a comparison between the predicted CSI and the actual CSI, and transmits the metrics to the gNB.