60-amino-acid polypeptide
    1.
    发明授权
    60-amino-acid polypeptide 失效
    60-氨基酸多肽

    公开(公告)号:US5202417A

    公开(公告)日:1993-04-13

    申请号:US396937

    申请日:1989-08-21

    申请人: Kyozo Hayashi

    发明人: Kyozo Hayashi

    IPC分类号: C07K14/475 C07K14/82

    CPC分类号: C07K14/82 C07K14/475

    摘要: Disclosed is a novel polypeptide whose N-terminus is EAQ and which is composed of 60 amino acids. The polypeptide is produced from human breast cancer cell MCF7, or human gastric cancer cell MKN-45 or KATO-III, which polypeptide has a isoelectric point of 4.3, a molecular weight of 6,661 and the following amino acid sequence: ##STR1##

    摘要翻译: 公开了一种新的多肽,其N末端为EAQ,由60个氨基酸组成。 该多肽由人乳腺癌细胞MCF7或人胃癌细胞MKN-45或KATO-III产生,该多肽具有等电点为4.3,分子量为6,661和以下氨基酸序列:EAQTETCTVAPRERQNCGFPGVTPSQCANK + TR GCCFDDTVRGVPWCFYPNTIDVPPEEECEF。

    Nerve growth factor secretion inducing composition
    2.
    发明授权
    Nerve growth factor secretion inducing composition 失效
    神经生长因子分泌诱导组成

    公开(公告)号:US5059627A

    公开(公告)日:1991-10-22

    申请号:US487249

    申请日:1990-03-02

    CPC分类号: A61K31/12

    摘要: A compound of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group; R.sup.2 is a hydrogen atom or an alkyl or alkenyl group which may be substituted; R.sup.3 and R.sup.4 each independently means a lower alkyl or lower alkoxy group or, taken together, mean a butadienylene group; and X.sup.1 and X.sup.2 each means a free hydroxy group or an esterified or etherified hydroxy group, has nerve growth factor secretion inducing activity, and a mammal suffering from degenerative nervous system disorders such as senile dementia, Alzheimer's disease, etc. is treated by administering said compound to said mammal.

    摘要翻译: 下式的化合物:其中R1是低级烷基;其中R1是低级烷基; R2是氢原子或可被取代的烷基或烯基; R 3和R 4各自独立地表示低级烷基或低级烷氧基,或者一起表示丁二烯基; X1和X2各自表示游离羟基或酯化或醚化的羟基,具有神经生长因子分泌诱导活性,并且通过施用所述的方法治疗患有退行性神经系统疾病如老年痴呆,阿尔茨海默氏病等的哺乳动物, 与所述哺乳动物复合。

    Optical connector
    3.
    发明授权
    Optical connector 失效
    光连接器

    公开(公告)号:US4779952A

    公开(公告)日:1988-10-25

    申请号:US437457

    申请日:1982-10-28

    IPC分类号: G02B6/38 G02B6/42

    摘要: An improved optical connector for connection between two pairs of optical connectors is proposed. It consists of a female housing and a male housing. One of the housings is adapted to hold plugs carrying the optical fibers with some clearance left with respect to the inner wall to allow lateral displacement of the plugs for self-alignment between the optical fibers connected.

    摘要翻译: 提出了一种用于在两对光连接器之间连接的改进的光连接器。 它包括一个女性住房和一个男性住房。 其中一个壳体适于容纳携带光纤的插头,其中相对于内壁留有一定间隙,以允许插头的横向位移在连接的光纤之间进行自对准。

    Protector for molten metal casting stream
    5.
    发明授权
    Protector for molten metal casting stream 失效
    熔融金属铸造流保护器

    公开(公告)号:US4369831A

    公开(公告)日:1983-01-25

    申请号:US99029

    申请日:1979-11-30

    申请人: Kyozo Hayashi

    发明人: Kyozo Hayashi

    IPC分类号: B22D7/12 B22D11/10 B22D11/106

    CPC分类号: B22D11/106

    摘要: A protector for a molten metal casting stream includes first and second pipes telescopically connected to each other to form a pipe assembly, and an urging means mounted about the pipe assembly so as to force it to extend in the lengthwise direction.

    摘要翻译: 用于熔融金属铸造流的保护器包括彼此可伸缩地连接以形成管组件的第一和第二管,以及安装在管组件周围以迫使其在长度方向上延伸的推动装置。

    Aromatic amide compounds and their production and use
    6.
    发明授权
    Aromatic amide compounds and their production and use 失效
    芳香族酰胺化合物及其生产和使用

    公开(公告)号:US5480907A

    公开(公告)日:1996-01-02

    申请号:US882025

    申请日:1992-05-13

    摘要: Aromatic amide compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, a lower alkyl or lower alkoxy group; Ar is an optionally substituted aromatic group; the groupC - - - -Cis C.dbd.C or HC--CH; X is hydrogen, CH.sub.2 COOH or CH.sub.2 CONHAr; and Y is hydrogen or COOH; provided that when X is CH.sub.2 COOH or Y is COOH, the COOH may be taken together with the adjacent hydroxy group on the benzene ring to form a lactone ring by dehydration, a quinone form thereof or a pharmaceutically acceptable salt thereof have potent nerve growth factor (NGF) secretion inducing activity, and are thus useful as a drug for the treatment or prophylaxis of degenerative nervous system disorders such as senilic dementis, and Alzheimer's disease.

    摘要翻译: 下式的芳族酰胺化合物:其中R 1,R 2和R 3独立地是氢,低级烷基或低级烷氧基; Ar是任选取代的芳族基团; C - - - C为C = C或HC-CH; X是氢,CH 2 COOH或CH 2 CONHAr; Y为氢或COOH; 条件是当X是CH 2 COOH或Y是COOH时,COOH可以与苯环上的相邻羟基一起与脱水形成内酯环,其醌形式或其药学上可接受的盐具有有效的神经生长因子 NGF)分泌诱导活性,因此可用作治疗或预防退行性神经系统疾病如老年性痴呆和阿尔茨海默氏病的药物。

    Ceramic-coated terminal for electrical connection
    7.
    发明授权
    Ceramic-coated terminal for electrical connection 失效
    陶瓷涂层端子用于电气连接

    公开(公告)号:US4925394A

    公开(公告)日:1990-05-15

    申请号:US290415

    申请日:1988-12-15

    IPC分类号: H01H1/021 H01R13/03

    CPC分类号: H01H1/021 H01R13/03

    摘要: A ceramic-coated terminal for electrical connection wherein an electrically conductive ceramic coating layer is provided on surface of the base material of the terminal and an electrically conductive intermediate layer is optionally provided between the base material and the electrically conductive ceramic coating layer, which terminal has good mechanical properties and durability.

    摘要翻译: PCT No.PCT / JP87 / 01048 Sec。 371日期:1988年12月15日 102(e)日期1988年12月15日PCT提交1987年12月28日PCT公布。 出版物WO88 / 08626 日期:1988年11月3日。一种用于电连接的陶瓷涂覆端子,其中在端子的基底材料的表面上设置导电陶瓷涂层,并且导电中间层可选地设置在基底材料和导电 陶瓷涂层,该端子具有良好的机械性能和耐久性。

    Connector for optical fibers with a gap
    8.
    发明授权
    Connector for optical fibers with a gap 失效
    具有间隙的光纤连接器

    公开(公告)号:US4714318A

    公开(公告)日:1987-12-22

    申请号:US378127

    申请日:1982-05-14

    摘要: A connector for connecting optical fibers together with a gap between their ends is proposed. It includes a body with a pair of walls, a pair of sleeves, a pair of plugs, and a pair of rod lenses carried by the sleeves. The rod lenses assure transmission of light with minimum loss in spite of the presence of a gap between the opposed ends of the optical cables.

    摘要翻译: 提出了用于将光纤连接在其端部之间的间隙的连接器。 它包括一个具有一对墙壁的主体,一对袖子,一对插头和一个由袖子承载的棒状透镜。 尽管在光缆的相对端之间存在间隙,杆透镜确保了具有最小损失的光的透射。