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35 条记录 (耗时 0.029 秒)

    Nerve growth factor secretion inducing composition
    1.
    发明授权
    Nerve growth factor secretion inducing composition 失效
    神经生长因子分泌诱导组成

    公开(公告)号：US5059627A

    公开(公告)日：1991-10-22

    申请号：US487249

    申请日：1990-03-02

    申请人： Giichi Goto ,  Kyozo Hayashi

    发明人： Giichi Goto ,  Kyozo Hayashi

    IPC分类号： A61K31/05 ,  A61K31/047 ,  A61K31/085 ,  A61K31/09 ,  A61K31/12 ,  A61K31/122 ,  A61K31/215 ,  A61K31/44 ,  A61K31/66 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

    CPC分类号： A61K31/12

    摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group; R.sup.2 is a hydrogen atom or an alkyl or alkenyl group which may be substituted; R.sup.3 and R.sup.4 each independently means a lower alkyl or lower alkoxy group or, taken together, mean a butadienylene group; and X.sup.1 and X.sup.2 each means a free hydroxy group or an esterified or etherified hydroxy group, has nerve growth factor secretion inducing activity, and a mammal suffering from degenerative nervous system disorders such as senile dementia, Alzheimer's disease, etc. is treated by administering said compound to said mammal.

    摘要翻译： 下式的化合物：其中R1是低级烷基;其中R1是低级烷基; R2是氢原子或可被取代的烷基或烯基; R 3和R 4各自独立地表示低级烷基或低级烷氧基，或者一起表示丁二烯基; X1和X2各自表示游离羟基或酯化或醚化的羟基，具有神经生长因子分泌诱导活性，并且通过施用所述的方法治疗患有退行性神经系统疾病如老年痴呆，阿尔茨海默氏病等的哺乳动物， 与所述哺乳动物复合。

    Cyclic amine compounds and their use
    3.
    发明授权
    Cyclic amine compounds and their use 失效
    环胺化合物及其用途

    公开(公告)号：US5441967A

    公开(公告)日：1995-08-15

    申请号：US171163

    申请日：1993-12-22

    申请人： Giichi Goto ,  Hidefumi Yukimasa ,  Tetsuji Imamoto

    发明人： Giichi Goto ,  Hidefumi Yukimasa ,  Tetsuji Imamoto

    IPC分类号： C12N9/99 ,  A61K31/00 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61P9/00 ,  A61P25/28 ,  C07D211/26 ,  C07D211/32 ,  C07D211/70 ,  C07D213/36 ,  C07D213/38 ,  C07D213/50 ,  C07D521/00 ,  C07D401/04

    CPC分类号： C07D231/12 ,  C07D211/26 ,  C07D211/32 ,  C07D211/70 ,  C07D213/38 ,  C07D213/50 ,  C07D233/56 ,  C07D249/08

    摘要： 1. A cyclic amine compound of the formula ##STR1## wherein B means a saturated or unsaturated 5- to 7-membered aza-heterocyclic group which may be substituted; A means a bond or an alkylene or alkenylene group which may be substituted by hydrocarbon residues, oxo, hydroxyimino, and/or hydroxy, .sub.-- means either a single bond or a double bond (provided that when A means a bond, .sub.-- means a single bond); R.sub.2 and R.sub.3 independently mean a hydrogen atom or a hydrocarbon residue which may be substituted (provided that both of R.sub.2 and R.sub.3 are not hydrogen atoms) or jointly form a cyclic amino group together with the adjacent nitrogen atom, n is 0, 1 or 2 and p is 1 or 2 or a physiologically acceptable salt thereof.The compounds are useful for therapy of cerebral edema, acute symptoms in cerebral apoplexy and protection of brain and nerve cell, or useful as anticholinesterase or as brain function-improving agent.

    摘要翻译： 1.下式的环胺化合物其中B表示可被取代的饱和或不饱和的5-至7-元氮杂杂环基; A表示可以被烃残基，氧代，羟基亚氨基和/或羟基取代的键或亚烷基或亚烯基， - 表示单键或双键（条件是当A表示键时， - 表示单键 键）; R2和R3独立地表示氢原子或可被取代的烃残基（条件是R2和R3都不是氢原子）或与相邻的氮原子一起形成环氨基，n是0,1或2 和p为1或2或其生理上可接受的盐。 该化合物可用于治疗脑水肿，脑中风的急性症状和保护脑和神经细胞，或用作抗胆碱酯酶或脑功能改善剂。

    Nitrosothiol derivatives and their use
    7.
    发明授权
    Nitrosothiol derivatives and their use 失效
    硝基苯酚衍生物及其用途

    公开(公告)号：US5116861A

    公开(公告)日：1992-05-26

    申请号：US562626

    申请日：1990-08-03

    申请人： Giichi Goto ,  Shigenori Ohkawa ,  Shoji Fukumoto

    发明人： Giichi Goto ,  Shigenori Ohkawa ,  Shoji Fukumoto

    IPC分类号： A61K38/00 ,  C07C381/00 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  C07K5/093

    CPC分类号： C07K5/0819 ,  C07C381/00 ,  C07K5/0215 ,  C07K5/0606 ,  A61K38/00

    摘要： Novel nitrosothiol derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently a hydrogen atom or a hydrocarbon residue which may be substituted; R.sup.3 is a hydrogen atom, an acyl group or a hydrocarbon residue which may be substituted; X.sup.1 is a hydrogen atom, an acyl group, a lower alkoxy group or a hydrocarbon residue which may be substituted; X.sup.2 is an acyl group or a carboxyl group which may be esterified or which may form an amide; with proviso that when X.sup.2 is a carboxyl group X.sup.1 is not a hydrogen atom or acetyl group and that when both R.sup.1 and R.sup.2 are hydrogen atoms X.sup.1 is not acetyl group or .gamma.-glutamyl group, and salts thereof, show excellent hypotensive action, antiarrhythmic action, anti-anginal action, cardiotonic action or coronary vasodilation, thus being useful as therapeutic or prophylactic agents for the cardiovascular diseases such as hypertension and angina pectoris.

    Use of idebenone and analogues against &bgr; amyloid induced cytotoxicity
    8.
    发明授权
    Use of idebenone and analogues against &bgr; amyloid induced cytotoxicity 失效
    使用艾地苯醌和类似物对β淀粉样蛋白诱导的细胞毒性

    公开(公告)号：US06271266B1

    公开(公告)日：2001-08-07

    申请号：US09180463

    申请日：1998-11-09

    申请人： Masaomi Miyamoto ,  Keisuke Hirai ,  Giichi Goto

    发明人： Masaomi Miyamoto ,  Keisuke Hirai ,  Giichi Goto

    IPC分类号： A61K31185

    CPC分类号： A61K31/047 ,  A61K31/122

    摘要： A compound of the formula: wherein R1 represents a lower alkyl; R2 represents H, an optionally substituted alkyl or an optionally substituted alkenyl; R3 and R4 each represents an optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, an optionally substituted butadienylene; and X1 and X2 each represents an optionally esterified or etherified hydroxy, or a salt thereof is useful for protecting cells from the cytotoxicity of &bgr;-amyloid protein.

    摘要翻译： 下式的化合物：其中R 1表示低级烷基; R 2表示H，任选取代的烷基或任选取代的烯基; R 3和R 4各自表示任选取代的低级烷基或低级烷氧基，或者R 3和R 4一起形成任选取代的亚二烯基; 并且X 1和X 2各自表示任选酯化或醚化的羟基，或其盐可用于保护细胞免受β-淀粉样蛋白的细胞毒性。

    Aminobenzene compounds to prevent nerve cell degradation
    9.
    发明授权
    Aminobenzene compounds to prevent nerve cell degradation 失效
    氨基苯化合物防止神经细胞降解

    公开(公告)号：US5580883A

    公开(公告)日：1996-12-03

    申请号：US266614

    申请日：1994-06-28

    申请人： Giichi Goto ,  Hidefumi Yukimasa ,  Masaomi Miyamoto

    发明人： Giichi Goto ,  Hidefumi Yukimasa ,  Masaomi Miyamoto

    IPC分类号： C07D211/46 ,  C07D211/58 ,  C07D401/12 ,  A61K31/445 ,  A61K31/38 ,  A61K31/44 ,  A61K31/535

    CPC分类号： C07D401/12 ,  C07D211/46 ,  C07D211/58

    摘要： A compound useful for central antioxidant having inhibitory activity of degeneration and necrocytosis of cerebral cells of the formula (I): ##STR1## wherein A and B are independently (1) a group of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are independently hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted heterocyclic group, or R.sub.1 together with R.sub.2 and the nitrogen atom to which they are bound may form a cyclic amino group, provided that both R.sub.1 and R.sub.2 are not hydrogen atom at the same time, or (2) a group of the formula: ##STR3## wherein D is O or S, R.sub.3 is hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group, m is 1, 2, or 3 and n is 0, 1, 2, 3 or 4;p is 1 or 2, provided that both A may be the same or different when p is 2; andR.sub.4, R.sub.5 and R.sub.6 are independently hydrogen atom, a lower alkyl or a lower alkoxy, or R.sub.5 and R.sub.6 may bond together to form --CH.dbd.CH--CH.dbd.CH--, or a salt thereof.

    摘要翻译： 可用于具有式（I）的脑细胞的变性和坏死细胞增多抑制活性的中枢抗氧化剂的化合物：其中R 1和R 2独立地为氢原子，任选取代的烃残基或 任选取代的杂环基，或R 1与R 2一起并且与它们结合的氮原子可以形成环状氨基，条件是R 1和R 2不得同时为氢原子，或（2）式 ：其中D是O或S，R 3是氢原子，任选取代的烃残基或任选取代的酰基，m是1,2或3，n是0,1,2,3或4; p为1或2，条件是当p为2时，A可以相同或不同; 并且R 4，R 5和R 6独立地为氢原子，低级烷基或低级烷氧基，或者R 5和R 6可以键合在一起形成-CH = CH-CH = CH-或其盐。