公开(公告)号：US20190071314A1

公开(公告)日：2019-03-07

申请号：US16122872

申请日：2018-09-05

Applicant: LEMONEX INC. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

Inventor： Dal-Hee MIN ,  Cheolhee WON ,  Sejin PARK ,  Seongchan KIM

IPC: C01B37/02 ,  C12N5/00 ,  A61K9/50 ,  A61K9/51 ,  B01J13/02 ,  B82Y5/00

Abstract: A composition includes porous silica particles to carry a cell fate modulating factor therein. A method for modulating cell fate includes treating various cells with the composition. The cell fate modulating factor is delivered to a stable target receptor, toxicity to subject cells for delivery may be reduced, a fate of the subject cells can be controlled through sustained release of at least 99 wt. % of the cell fate modulating factor.

公开(公告)号：US20210137922A1

公开(公告)日：2021-05-13

申请号：US16476220

申请日：2018-01-08

Applicant: LEMONEX INC.

Inventor： Jae Ho LEE ,  Dal-Hee MIN ,  Cheolhee WON

IPC: A61K31/506 ,  A23L33/10 ,  A61K31/337 ,  A61K31/475 ,  A61K31/165 ,  A61K31/343 ,  A61K33/243 ,  A61P35/04

Abstract: A method for treatment of cancer selected from the group consisting of metastatic ovarian cancer, endometrial cancer, and breast cancer includes administering a composition comprising a compound represented by Formula 1, a pharmaceutically acceptable salt thereof to a subject in need thereof: The composition can efficiently kill cancer cells present in a spheroid form, thereby being usefully applied as novel medicament for metastatic ovarian cancer, endometrial cancer or breast cancer.

公开(公告)号：US20180306718A1

公开(公告)日：2018-10-25

申请号：US15765409

申请日：2016-06-15

Applicant: LEMONEX INC.

Inventor： Cheolhee WON ,  Dal-Hee MIN

IPC: G01N21/64 ,  C12N15/115 ,  C12N1/20 ,  C08B37/08 ,  G01N33/574

Abstract: A quencher containing water-soluble polymer-conjugated nanomaterial effectively quenches the fluorescence of a fluorescent material-conjugated probe. In addition, a composition including the quencher and a fluorescent material-conjugated probe can detect a target material existing at a low concentration, and thus can be favorably used as a composition or kit for providing information necessary for the detection of a biomaterial or the diagnosis of a disease.