-
1.发明申请公开(公告)号：US20160346344A1
公开(公告)日：2016-12-01
申请号：US15235752
申请日：2016-08-12
申请人： Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/484 , A23L33/105 , A61K36/489 , A61K36/185 , A61K31/352 , A61K36/254
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。
-
2.发明授权公开(公告)号：US09446087B2
公开(公告)日：2016-09-20
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Laurie Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/489 , A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/804
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。
-
3.发明申请公开(公告)号：US20080199545A1
公开(公告)日：2008-08-21
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/254 , A61K36/48 , A61K36/87 , A61P19/00
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。
-
公开(公告)号：USD404497S
公开(公告)日：1999-01-19
申请号：US44623
申请日：1995-09-27
-
公开(公告)号：USD378941S
公开(公告)日：1997-04-22
申请号：US44624
申请日：1995-09-27
-
6.发明授权
公开(公告)号：US5518878A
公开(公告)日：1996-05-21
申请号：US121377
申请日：1993-09-15
申请人： Leon M. Wilkins , Stephen R. Watson
发明人： Leon M. Wilkins , Stephen R. Watson
CPC分类号： A01N1/02 , A01N1/0221
摘要： This invention is directed to cryopreservation of cultured tissue equivalents made by in vitro technology. The invention involves immersing a cultured tissue equivalent in a cooled cryoprotectant solution, agitating the cryoprotectant solution and the immersed cultured tissue to achieve effective penetration of the cryoprotectant solution into the cultured tissue equivalent, and then freezing the cultured tissue at a high freezing rate. The cryopreserved cultured tissue equivalent may be stored for indefinite periods of time prior to use. The cultured tissue equivalent is an in vitro model of the equivalent human tissue, which, when retrieved from storage can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译： 本发明涉及通过体外技术制备的培养组织等同物的低温保存。 本发明涉及将冷冻冷冻保护剂溶液中的培养组织当量浸入，搅拌冷冻保护剂溶液和浸没的培养组织以实现冷冻保护剂溶液有效渗透到培养组织当量中，然后以高冷冻速率冷冻培养的组织。 冷冻保存的培养组织等同物可以在使用前储存无限期。 培养的组织等效物是等效人体组织的体外模型，当从储存中取出时可以用于体内移植或植入或用于体外筛选化合物。
-
公开(公告)号：US5252322A
公开(公告)日：1993-10-12
申请号：US815867
申请日：1992-01-03
申请人： Karla L. Stoner , Leon M. Wilkins
发明人： Karla L. Stoner , Leon M. Wilkins
CPC分类号： A61Q19/04 , A61K8/4946 , A61Q17/04 , Y10S514/844 , Y10S514/847 , Y10S514/944
摘要： A skin tanning composition comprising an effective amount of imidazole or an imidazole derivative in a dermatologically acceptable vehicle.
摘要翻译： 一种在皮肤病学可接受的载体中包含有效量的咪唑或咪唑衍生物的皮肤鞣制组合物。
-
8.发明申请公开(公告)号：US20080199546A1
公开(公告)日：2008-08-21
申请号：US11977395
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/82 , C12N5/02 , A61K36/87 , A61K36/00 , A61K31/352
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译： 本文公开了用于增加或刺激骨生长和减少或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，所述第一组合物包含以下组合中的至少两种：槲皮素，地黄，地黄， 根，西伯利亚人参，苦参，甘草和异丙酚，其中第一组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。
-
公开(公告)号：US06730510B2
公开(公告)日：2004-05-04
申请号：US10189300
申请日：2002-07-02
IPC分类号： C12M134
摘要： A bioreactor has a base for defining a well, a dish with a membrane suspended in the base, and a lid with gas permeable membranes and self-sealing ports.
摘要翻译： 生物反应器具有用于限定孔的基底，具有悬浮在基底中的膜的盘，以及具有透气膜和自密封端口的盖。
-
公开(公告)号：US5795775A
公开(公告)日：1998-08-18
申请号：US721393
申请日：1996-09-26
申请人： William J. Lahm , Timothy A. Stevens , Alexander G. Tschumakow , Leon M. Wilkins , John M. Janson , Stephen C. Conley
发明人： William J. Lahm , Timothy A. Stevens , Alexander G. Tschumakow , Leon M. Wilkins , John M. Janson , Stephen C. Conley
摘要： An assembly and components therefor are disclosed for use in the field of cell and tissue culture. The assembly includes a base having one or more wells, and a cell culture insert which is mountable to the base such that the bottom wall of the insert is suspended within the well. Each well has a generally rectangular configuration such that openings are provided at each corner of the well for introducing fluid to the well. A cover is provided for protecting the assembly and maintaining the position of the cell culture insert.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.017 秒)
