公开(公告)号：US07718201B2

公开(公告)日：2010-05-18

申请号：US12218585

申请日：2008-07-16

申请人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

发明人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

IPC分类号： A61K35/78

CPC分类号： A61K36/79 ,  A61K36/21 ,  A61K36/258 ,  A61K36/28 ,  A61K36/31 ,  A61K36/488 ,  A61K36/53 ,  A61K36/8965 ,  Y10S514/893 ,  A61K2300/00

摘要： The present invention is directed to plant based formulations for improving liver health by protecting the liver from alcohol and chemical insults and/or by inducing phase II enzymes. Formulations according to the present invention include wasabi root fiber powder, artichoke leaf extract, asparagus dehydrate, kudzu root extract, oregano extract, schisandra berry extract, notoginseng (ethanol extract of Panax notoginseng root), sanchi (water extracts from Panax notoginseng root), Gegen root extract (Pueraria omeiensis), spinach dehydrate, or combinations thereof.

摘要翻译： 本发明涉及通过保护肝脏免受酒精和化学损伤和/或通过诱导II期酶改善肝健康的基于植物的制剂。 根据本发明的制剂包括芥子根纤维粉，朝鲜蓟叶提取物，芦笋脱水，葛根提取物，牛至提取物，五味子浆果提取物，三七（三七乙醇提取物），sanchi（三七提取物） 葛根根提取物（Pueraria omeiensis），菠菜脱水剂或其组合。

公开(公告)号：US20090011054A1

公开(公告)日：2009-01-08

申请号：US12218585

申请日：2008-07-16

申请人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

发明人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

IPC分类号： A61K36/258 ,  A61P1/16

CPC分类号： A61K36/79 ,  A61K36/21 ,  A61K36/258 ,  A61K36/28 ,  A61K36/31 ,  A61K36/488 ,  A61K36/53 ,  A61K36/8965 ,  Y10S514/893 ,  A61K2300/00

摘要： The present invention is directed to plant based formulations for improving liver health by protecting the liver from alcohol and chemical insults and/or by inducing phase II enzymes. Formulations according to the present invention include wasabi root fiber powder, artichoke leaf extract, asparagus dehydrate, kudzu root extract, oregano extract, schisandra berry extract, notoginseng (ethanol extract of Panax notoginseng root), sanchi (water extracts from Panax notoginseng root), Gegen root extract (Pueraria omeiensis), spinach dehydrate, or combinations thereof.

摘要翻译： 本发明涉及通过保护肝脏免受酒精和化学损伤和/或通过诱导II期酶改善肝健康的基于植物的制剂。 根据本发明的制剂包括芥子根纤维粉，朝鲜蓟叶提取物，芦笋脱水，葛根提取物，牛至提取物，五味子浆果提取物，三七（三七乙醇提取物），sanchi（三七提取物） 葛根根提取物（Pueraria omeiensis），菠菜脱水剂或其组合。

公开(公告)号：US07419689B2

公开(公告)日：2008-09-02

申请号：US11274618

申请日：2005-11-15

申请人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

发明人： Chioma Jane Ikonte ,  Michael Huang ,  Cherie L. Hacker ,  Silvia R. da Costa ,  Paul D. Johnson ,  Amitabh Chandra ,  Christine M. Paganelli ,  Ruo G. Huang

IPC分类号： A61K35/78

CPC分类号： A61K36/79 ,  A61K36/21 ,  A61K36/258 ,  A61K36/28 ,  A61K36/31 ,  A61K36/488 ,  A61K36/53 ,  A61K36/8965 ,  Y10S514/893 ,  A61K2300/00

摘要： The present invention is directed to plant based formulations for improving liver health by protecting the liver from alcohol and chemical insults and/or by inducing phase II enzymes. Formulations according to the present invention include wasabi root fiber powder, artichoke leaf extract, asparagus dehydrate, kudzu root extract, oregano extract, schisandra berry extract, notoginseng (ethanol extract of Panax notoginseng root), sanchi (water extracts from Panax notoginseng root), Gegen root extract (Pueraria omeiensis), spinach dehydrate, or combinations thereof.

摘要翻译： 本发明涉及通过保护肝脏免受酒精和化学损伤和/或通过诱导II期酶改善肝健康的基于植物的制剂。 根据本发明的制剂包括芥子根纤维粉，朝鲜蓟叶提取物，脱水芦笋，葛根提取物，牛至提取物，五味子浆果提取物，三七（三七乙醇提取物），sanchi（三七提取物） 葛根根提取物（Pueraria omeiensis），菠菜脱水剂或其组合。

公开(公告)号：US20080199546A1

公开(公告)日：2008-08-21

申请号：US11977395

申请日：2007-10-24

申请人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

IPC分类号： A61K36/82 ,  C12N5/02 ,  A61K36/87 ,  A61K36/00 ,  A61K31/352

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长和减少或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，所述第一组合物包含以下组合中的至少两种：槲皮素，地黄，地黄， 根，西伯利亚人参，苦参，甘草和异丙酚，其中第一组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US11207368B2

公开(公告)日：2021-12-28

申请号：US15235752

申请日：2016-08-12

申请人： Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K31/352 ,  A61K36/185 ,  A61K36/258 ,  A61K36/484 ,  A61K36/804 ,  A61K36/489 ,  A23L33/105 ,  A61K36/254

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

公开(公告)号：US20160346344A1

公开(公告)日：2016-12-01

申请号：US15235752

申请日：2016-08-12

申请人： Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K36/484 ,  A23L33/105 ,  A61K36/489 ,  A61K36/185 ,  A61K31/352 ,  A61K36/254

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US09446087B2

公开(公告)日：2016-09-20

申请号：US11977696

申请日：2007-10-24

申请人： David W. Krempin ,  Laurie Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K36/489 ,  A61K31/352 ,  A61K36/185 ,  A61K36/258 ,  A61K36/484 ,  A61K36/804

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US20080199545A1

公开(公告)日：2008-08-21

申请号：US11977696

申请日：2007-10-24

申请人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

IPC分类号： A61K36/254 ,  A61K36/48 ,  A61K36/87 ,  A61P19/00

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。