公开(公告)号：US20080199546A1

公开(公告)日：2008-08-21

申请号：US11977395

申请日：2007-10-24

申请人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

IPC分类号： A61K36/82 ,  C12N5/02 ,  A61K36/87 ,  A61K36/00 ,  A61K31/352

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长和减少或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，所述第一组合物包含以下组合中的至少两种：槲皮素，地黄，地黄， 根，西伯利亚人参，苦参，甘草和异丙酚，其中第一组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US09446087B2

公开(公告)日：2016-09-20

申请号：US11977696

申请日：2007-10-24

申请人： David W. Krempin ,  Laurie Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K36/489 ,  A61K31/352 ,  A61K36/185 ,  A61K36/258 ,  A61K36/484 ,  A61K36/804

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US20080199545A1

公开(公告)日：2008-08-21

申请号：US11977696

申请日：2007-10-24

申请人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast ,  Laurie Krempin

IPC分类号： A61K36/254 ,  A61K36/48 ,  A61K36/87 ,  A61P19/00

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US11207368B2

公开(公告)日：2021-12-28

申请号：US15235752

申请日：2016-08-12

申请人： Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K31/352 ,  A61K36/185 ,  A61K36/258 ,  A61K36/484 ,  A61K36/804 ,  A61K36/489 ,  A23L33/105 ,  A61K36/254

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

公开(公告)号：US20160346344A1

公开(公告)日：2016-12-01

申请号：US15235752

申请日：2016-08-12

申请人： Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

发明人： David W. Krempin ,  Mary A. Murray ,  Yumei Lin ,  Kevin W. Gellenbeck ,  Silvia R. da Costa ,  Leon M. Wilkins ,  Haeri Roh-Schmidt ,  Jatinder Rana ,  John F. Rebhun ,  David J. Fast

IPC分类号： A61K36/87 ,  A61K36/484 ,  A23L33/105 ,  A61K36/489 ,  A61K36/185 ,  A61K31/352 ,  A61K36/254

CPC分类号： A61K36/87 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/484 ,  A61K36/489 ,  A61K36/804 ,  A61K2300/00

摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

摘要翻译： 本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精 根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

公开(公告)号：US07838050B2

公开(公告)日：2010-11-23

申请号：US10938093

申请日：2004-09-10

申请人： Russell K. Randolph ,  Haeri Roh-Schmidt ,  Mary A. Murray ,  Aaron W. Crawford ,  Kevin W. Gellenbeck ,  Donald J. Pusateri

发明人： Russell K. Randolph ,  Haeri Roh-Schmidt ,  Mary A. Murray ,  Aaron W. Crawford ,  Kevin W. Gellenbeck ,  Donald J. Pusateri

IPC分类号： A61K36/45 ,  A61K36/73 ,  A61K36/906

CPC分类号： A61K36/87 ,  A61K31/05 ,  A61K31/122 ,  A61K36/07 ,  A61K36/185 ,  A61K36/28 ,  A61K36/30 ,  A61K36/324 ,  A61K36/45 ,  A61K36/53 ,  A61K36/61 ,  A61K36/63 ,  A61K36/738 ,  A61K36/74 ,  A61K36/82 ,  A61K36/906 ,  Y10S514/885 ,  A61K2300/00

摘要： A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and/or inflammatory response, and subsequently treat diseases and/or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.

摘要翻译： 用于调节细胞因子以调节炎症或免疫调节反应的组合物。 组合物可以包括玫瑰果，蓝莓，黑莓，接骨木，蔓越莓，迷迭香，丁香，发烧，荨麻根，朝鲜蓟，芦苇蘑菇，橄榄提取物，绿茶提取物，葡萄籽提取物，白藜芦醇，Aframomum melegueta，boswellia serrata中的至少一种 提取物，富马酸，异丙酚，生育三烯酚，月见草油，INM-176，琉璃苣油，磷虾油，至少一种类型的叶黄素（例如虾青素），生咖啡提取物和阿魏酸。 具体地说，本发明的组合物可以包括：玫瑰果和黑莓，蓝莓，接骨木和任选的磷虾油中的至少一种; 或玫瑰果，白藜芦醇和Aframomum melegueta和虾青素中的至少一种。 基于组合物的细胞因子调节和细胞因子反应抑制，其可用于调节免疫调节和/或炎症反应，并且随后治疗与炎症反应相关的疾病和/或异常状况，例如心血管疾病，关节炎，骨质疏松症 和阿尔茨海默病。

公开(公告)号：US07588785B2

公开(公告)日：2009-09-15

申请号：US11624687

申请日：2007-01-18

申请人： Gregory S. Evans ,  Gregory Grochoski ,  Russell K. Randolph ,  Lynne M. Connor ,  John V. Scimeca ,  Kevin W. Gellenbeck ,  James R. Mayne ,  Haeri Roh-Schmidt ,  Thomas J. Slaga ,  Margaret Hanausek-Walaszek ,  Zbigniew Walaszek

发明人： Gregory S. Evans ,  Gregory Grochoski ,  Russell K. Randolph ,  Lynne M. Connor ,  John V. Scimeca ,  Kevin W. Gellenbeck ,  James R. Mayne ,  Haeri Roh-Schmidt ,  Thomas J. Slaga ,  Margaret Hanausek-Walaszek ,  Zbigniew Walaszek

IPC分类号： A61K36/82 ,  A61K36/736 ,  A61K36/752 ,  A61K36/906 ,  A61K36/00

CPC分类号： A61K45/06 ,  A61K31/015 ,  A61K31/22 ,  A61K31/355 ,  A61K31/375 ,  A61K36/35 ,  A61K36/736 ,  A61K36/82 ,  A61K36/87 ,  A61K2300/00

摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.

摘要翻译： 描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型 抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。 还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

公开(公告)号：US09265277B2

公开(公告)日：2016-02-23

申请号：US13548604

申请日：2012-07-13

申请人： Kevin W. Gellenbeck ,  Dawna Salter Venzon ,  Amitabh Chandra ,  Janjira Intra ,  Kerry A. Grann

发明人： Kevin W. Gellenbeck ,  Dawna Salter Venzon ,  Amitabh Chandra ,  Janjira Intra ,  Kerry A. Grann

IPC分类号： A23L1/00 ,  A23L1/275 ,  A23L1/303 ,  A61K31/07 ,  A61K31/122 ,  A61K9/50 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047

CPC分类号： A23L1/303 ,  A23L5/44 ,  A23L33/155 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/5073 ,  A61K31/01 ,  A61K31/015 ,  A61K31/047 ,  A61K31/07 ,  A61K31/122 ,  A23V2250/211 ,  A23V2250/213 ,  A61K2300/00

摘要： A controlled release beadlet that sequentially releases carotenoids over time within the gastrointestinal tract of a subject, as well as a method of administering the carotenoids. The beadlet provides a specific ratio of carotenoids which release from the beadlet at preselected times during passage through the gastrointestinal tract. The method includes releasing the carotenoids in preselected ratios at specific time intervals in the gastrointestinal tract to mitigate competition between the carotenoids for their uptake, and/or to potentially maximize the uptake of individual carotenoids within a mixed carotenoid formulation.

摘要翻译： 在受试者的胃肠道内随时间依次释放类胡萝卜素的控释珠粒以及施用类胡萝卜素的方法。 珠粒提供在通过胃肠道期间预选时间从珠粒释放的类胡萝卜素的比例。 该方法包括以预定比例在胃肠道中以特定的时间间隔释放类胡萝卜素，以减轻类胡萝卜素摄取之间的竞争和/或潜在地最大化混合类胡萝卜素制剂中各种类胡萝卜素的摄取。

公开(公告)号：US5827539A

公开(公告)日：1998-10-27

申请号：US580385

申请日：1995-12-28

申请人： Kevin W. Gellenbeck

发明人： Kevin W. Gellenbeck

IPC分类号： A23L1/00 ,  A23L1/275 ,  A23L1/30 ,  A61K9/14 ,  B01J13/02 ,  C07C403/00 ,  C07C403/02 ,  C07C403/24 ,  C09B61/00 ,  C09B67/00 ,  C09B67/08 ,  C09B67/20 ,  C09K15/06

CPC分类号： C07C403/24 ,  A23L33/105 ,  A23L5/44 ,  A23P10/30 ,  B01J13/02 ,  C09B61/00 ,  C09B67/0095

摘要： A dry powder that contains carotenoids produced by grinding a mixture of carotenoids and oil to reduce the carotenoid particle size, emulsifying the mixture with an encapsulating mixture, and drying the emulsification. The encapsulating mixture includes a starch encapsulating agent, a sugar, and an anti-oxidant. The resulting water-dispersible powder contains a high concentration of carotenoids, yet is protected from oxidation.

公开(公告)号：US5976575A

公开(公告)日：1999-11-02

申请号：US126564

申请日：1998-07-30

申请人： Kevin W. Gellenbeck

发明人： Kevin W. Gellenbeck

IPC分类号： A23L1/00 ,  A23L1/275 ,  A23L1/30 ,  A61K9/14 ,  B01J13/02 ,  C07C403/00 ,  C07C403/02 ,  C07C403/24 ,  C09B61/00 ,  C09B67/00 ,  C09B67/08 ,  C09B67/20 ,  C09K15/06

CPC分类号： C07C403/24 ,  A23L33/105 ,  A23L5/44 ,  A23P10/30 ,  B01J13/02 ,  C09B61/00 ,  C09B67/0095

摘要： A dry powder that contains carotenoids produced by grinding a mixture of carotenoids and oil to reduce the carotenoid particle size, emulsifying the mixture with an encapsulating mixture, and drying the emulsification. The encapsulating mixture includes a starch encapsulating agent, a sugar, and an anti-oxidant. The resulting water-dispersible powder contains a high concentration of carotenoids, yet is protected from oxidation.

摘要翻译： 含有通过研磨类胡萝卜素和油的混合物而产生的类胡萝卜素的干粉，以减少类胡萝卜素的粒径，用包封的混合物乳化混合物，并干燥乳化。 包封混合物包括淀粉包封剂，糖和抗氧化剂。 所得到的水分散性粉末含有高浓度的类胡萝卜素，但不受氧化。