公开(公告)号：US08715340B2

公开(公告)日：2014-05-06

申请号：US11786023

申请日：2007-04-09

申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Michael O'Connor

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/065

摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

摘要翻译： 描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。 一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。 材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。 在一些实施方案中，孔径范围为约10-100μm。 在一些实施方案中，孔等距离地间隔开约40-100μm的孔隙。 孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。 在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。

公开(公告)号：US08328840B2

公开(公告)日：2012-12-11

申请号：US11825956

申请日：2007-07-09

申请人： Philippe Gailloud ,  Leon Rudakov

发明人： Philippe Gailloud ,  Leon Rudakov

IPC分类号： A61M29/00

CPC分类号： A61B17/12031 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/00893 ,  A61B2017/1205

摘要： An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

摘要翻译： 描述了包括可扩展支架和限流部件的闭塞装置。 在一些实施方案中，支架是可在导丝上传送的可扩张或自扩张支架。 限流构件可以包括在展开之后可以关闭的阀。 在展开时，支架和限流构件可以接合体腔内腔的内表面，阻止材料的流动。 在一些实施例中，体腔是血管，并且该装置可用于阻止血液流动。 在一些实施方案中，该装置包括生物活性剂。

公开(公告)号：US20120192872A1

公开(公告)日：2012-08-02

申请号：US13367338

申请日：2012-02-06

申请人： Leon Rudakov ,  Tanner J. Hargens ,  Phillip M. Leopold

发明人： Leon Rudakov ,  Tanner J. Hargens ,  Phillip M. Leopold

IPC分类号： A61F6/06

CPC分类号： A61F6/18 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/12159 ,  A61B2017/00809 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/1209 ,  A61F6/08 ,  A61F6/146 ,  A61F6/20 ,  A61F6/225

摘要： Described are apparatus and methods for preventing sperm passage through a reproductive structure of a patient, and also for subsequently reversing the preventative measure in order to restore fertility to the patient. In some embodiments, the apparatus includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the reproductive structure. The apparatus may also have a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially impedes, reduces, or totally obstructs passage of sperm through the lumen.

摘要翻译： 描述了用于防止精子通过患者的生殖结构的装置和方法，并且还用于随后逆转预防措施以恢复对患者的生育能力。 在一些实施例中，该装置包括细长构件，该细长构件布置成形成具有远侧和近侧开口并构造成定位在生殖结构内腔内的框架。 该装置还可以具有联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上阻止，减少或完全阻碍精子通过内腔的通道。

公开(公告)号：US20140222059A1

公开(公告)日：2014-08-07

申请号：US13828974

申请日：2013-03-14

申请人： Andrew LEOPOLD ,  Leon RUDAKOV ,  Kelly JENSEN

发明人： Andrew LEOPOLD ,  Leon RUDAKOV ,  Kelly JENSEN

IPC分类号： A61B17/12

CPC分类号： A61B17/12109 ,  A61B17/12031 ,  A61B17/12145 ,  A61B17/1215 ,  A61B2017/12054

摘要： An occlusion device delivery system and methods are provided in which an expandable coiled implant can be delivered using the delivery system. The system can comprise a catheter having a lumen extending between distal and proximal portions. The distal portion can have proximal and distal apertures extending through a wall of the catheter. The expandable coiled implant, which can be wound about the distal portion, can have a proximal section that extends within the proximal aperture and a distal section that can extend radially within the distal aperture. Further, the system can comprise an elongate member that extends through the lumen and engages and radially restrains the at least one of the proximal and distal sections within its respective aperture while engaged with the member.

摘要翻译： 提供了一种闭塞装置递送系统和方法，其中可使用递送系统递送可扩张盘管植入物。 该系统可以包括具有在远端部分和近端部分之间延伸的内腔的导管。 远侧部分可以具有延伸穿过导管壁的近端和远端孔。 可以围绕远端部分缠绕的可扩张盘绕植入物可以具有在近端孔内延伸的近端部分和可在远端孔径内径向延伸的远端部分。 此外，该系统可以包括延伸穿过内腔的细长构件，并且在与构件接合的同时接合并径向地限制其相应孔内的近端部分和远端部分中的至少一个。

公开(公告)号：US20120095489A1

公开(公告)日：2012-04-19

申请号：US12906993

申请日：2010-10-18

申请人： Leon RUDAKOV ,  Andrew R. Leopold ,  Kelly L. Jensen ,  Philippe Gailloud

发明人： Leon RUDAKOV ,  Andrew R. Leopold ,  Kelly L. Jensen ,  Philippe Gailloud

IPC分类号： A61M29/02

CPC分类号： A61B17/12031 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/1215 ,  A61B2017/1205 ,  A61B2017/12054

摘要： A device for delivering an expandable member to a luminal structure in a patient is described. In some embodiments, the device has a carrier member, with a carrier lumen extending at least partially therethrough. The device can have an elongate member that extends through the carrier lumen across a first notch in the carrier member. The device can have an expandable member that expands within and engages the luminal structure, can be carried by the carrier member, and has a first portion that fits within the first notch. When the elongate member extends through the carrier lumen and across the first notch, the elongate member secures the first portion to the carrier member. The elongate member is configured to move axially through the carrier lumen such that the elongate member permits release of the first portion from the carrier member and expansion of at least part of the expandable member.

摘要翻译： 描述了用于将可扩张构件递送到患者体内的腔体结构的装置。 在一些实施例中，该装置具有载体构件，其中载体腔至少部分延伸穿过其中。 该装置可以具有延伸穿过载体内腔的细长构件跨越载体构件中的第一凹口。 该装置可以具有在腔体结构内扩张并与腔体结构接合的可扩张构件，其可以由承载构件承载，并且具有装配在第一凹口内的第一部分。 当细长构件延伸穿过载体内腔并穿过第一凹口时，细长构件将第一部分固定到载体构件。 细长构件被构造成轴向地移动穿过载体腔，使得细长构件允许第一部分从承载构件释放并且至少部分可扩张构件的膨胀。

公开(公告)号：US20110319906A1

公开(公告)日：2011-12-29

申请号：US12826593

申请日：2010-06-29

申请人： Leon RUDAKOV ,  Phillipe GAILLOUD

发明人： Leon RUDAKOV ,  Phillipe GAILLOUD

IPC分类号： A61B17/22 ,  A61B17/00

CPC分类号： A61B17/12145 ,  A61B17/12036 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/1215 ,  A61B2017/00469 ,  A61B2017/00809 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/1209 ,  A61B2017/22035

摘要： In some embodiments, an apparatus, for reducing or stopping flow through a tubular structure of a patient, includes an elongate member arranged to form a frame having a distal and proximal opening and configured to be positioned within a lumen of the tubular structure. The frame includes a proximal, distal, and middle portion. The distal portion is tapered such that an outer cross sectional dimension (OCSD) of the distal opening is less than an OCSD of the middle portion. The frame is configured to be inverted such that the distal portion moves within and toward the middle portion for removing the frame from within the lumen. The apparatus also comprises a flow reducing member coupled to the frame such that when the frame is positioned within the lumen, the flow reducing member substantially reduces or totally obstructs flow of at least one of emboli and fluid flowing through the lumen.

摘要翻译： 在一些实施例中，用于减少或阻止穿过患者的管状结构的流动的装置包括细长构件，该细长构件布置成形成具有远端和近侧开口并被配置为定位在管状结构的内腔内的框架。 框架包括近端，远端和中间部分。 远侧部分是锥形的，使得远端开口的外横截面尺寸（OCSD）小于中间部分的OCSD。 框架被构造成倒置，使得远端部分在中间部分内移动并朝向中间部分移动，以从框架内移除框架。 该装置还包括联接到框架的流动减少构件，使得当框架定位在内腔内时，减流构件基本上减少或完全阻碍栓塞和流过管腔的流体中的至少一个的流动。

公开(公告)号：US20100063531A1

公开(公告)日：2010-03-11

申请号：US12093310

申请日：2005-11-09

申请人： Leon Rudakov ,  Michael O'Connor ,  Vimal Raj D

发明人： Leon Rudakov ,  Michael O'Connor ,  Vimal Raj D

IPC分类号： A61M29/00 ,  A61B5/00

CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B2017/1205 ,  A61F2/07 ,  A61F2/89 ,  A61F2/958 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2220/0058

摘要： PCT A medical device (10) for insertion into a bodily vessel (4) to treat an aneurysm (5) having an aneurysm neck, the device (10) comprising: a mechanically expandable device expandable from a first position to a second position; the mechanically expandable device having an exterior circumferential surface at end portions (11, 12) of the mechanically expandable device such that the exterior circumferential surface engages with the inner surface of the vessel (4) so as to maintain a fluid pathway through said vessel (4) when the end portions (11, 12) of the mechanically expandable device are expanded radially outwardly to the second position; the mechanically expandable device having an exterior non-circumferential surface at a connecting portion (13) of the mechanically expandable device to connect the end portions (11, 12); and an expandable membrane (15) extending over a portion of the exterior non-circumferential surface, the membrane (15) is expanded in response to expansion of the mechanically expandable device; wherein the connecting portion (13) is positioned proximal to the aneurysm neck such that the expanded membrane (15) obstructs blood circulation to the aneurysm (5).

摘要翻译： PCT一种用于插入身体血管（4）以治疗具有动脉瘤颈部的动脉瘤（5）的医疗装置（10），所述装置（10）包括：可从第一位置扩展到第二位置的机械可扩张装置; 所述机械可扩张装置在所述机械可扩张装置的端部部分（11,12）处具有外周表面，使得所述外周表面与所述容器（4）的内表面接合，以便保持通过所述容器的流体路径（ 4）当机械可膨胀装置的端部部分（11,12）径向向外延伸到第二位置时; 所述机械可扩张装置在所述机械可扩张装置的连接部分（13）处具有外部非圆周表面，以连接所述端部部分（11,12）; 以及在所述外部非圆周表面的一部分上延伸的可膨胀膜（15），所述膜（15）响应于所述机械可扩张装置的膨胀而膨胀; 其中所述连接部分（13）位于所述动脉瘤颈部的近侧，使得所述扩张的膜（15）阻止血液循环到所述动脉瘤（5）。

公开(公告)号：US20090054966A1

公开(公告)日：2009-02-26

申请号：US12279335

申请日：2006-02-13

申请人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

发明人： Leon Rudakov ,  Tsui Ying Rachel Hong ,  Peir Fen Sung

IPC分类号： A61F2/06

CPC分类号： C08G18/283 ,  A61F2/07 ,  A61F2250/0023 ,  A61L31/06 ,  C08G18/2885 ,  C08G18/289 ,  C08G18/44 ,  C08L75/04

摘要： An endovascular device (10) for insertion into a bodily vessel (5) to treat a diseased, damaged or weakened portion of a vessel wall (50), the endovascular device (10) comprising: a mechanically expandable device (11) expandable from a first position to a second position, said mechanically expandable device (11) is expanded radially outwardly to the second position such that the circumferential surface of said mechanically expandable device (11) engages with the inner surface of the vessel (5) so as to maintain a fluid pathway through said vessel (5); and a membrane (20) covering at least a portion of the circumferential surface of said mechanically expandable device (11), the membrane (20) comprising a plurality of pores (25), the porosity of the membrane (20) being defined by the ratio of the material surface area of the membrane (20) determined by the size of the pores (21) and the distance between adjacent pores (22, 23); wherein the mechanically expandable device (10) is positioned in the bodily vessel (5) such that the membrane (20) covers at least the diseased, damaged or weakened portion of the vessel wall (50), the porosity of the membrane (20) obstructing blood supply to the diseased, damaged or weakened portion of the vessel wall (50) and enhancing healing of the bodily vessel (5).

摘要翻译： 一种用于插入身体血管（5）以治疗血管壁（50）的患病，受损或弱化部分的血管内装置（10），所述血管内装置（10）包括：机械可扩张装置（11），其可从 第一位置到第二位置，所述机械可扩张装置（11）径向向外扩展到第二位置，使得所述机械可扩张装置（11）的圆周表面与容器（5）的内表面接合，以便保持 通过所述容器（5）的流体通道; 以及覆盖所述机械可扩张装置（11）的所述圆周表面的至少一部分的膜（20），所述膜（20）包括多个孔（25），所述膜（20）的孔隙度由 通过孔（21）的尺寸和相邻孔（22,23）之间的距离确定的膜（20）的材料表面积的比率; 其中所述机械可扩张装置（10）定位在所述身体容器（5）中，使得所述膜（20）至少覆盖所述血管壁（50）的患病，受损或弱化部分，所述膜（20）的孔隙率 阻止对血管壁（50）的患病，受损或弱化部分的血液供应，并增强身体血管（5）的愈合。

公开(公告)号：US20090018636A1

公开(公告)日：2009-01-15

申请号：US11825956

申请日：2007-07-09

申请人： Philippe Gailloud ,  Leon Rudakov

发明人： Philippe Gailloud ,  Leon Rudakov

IPC分类号： A61F2/06 ,  A61B19/00 ,  A61M25/10

CPC分类号： A61B17/12031 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/00867 ,  A61B2017/00893 ,  A61B2017/1205

摘要： An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

摘要翻译： 描述了包括可扩展支架和限流部件的闭塞装置。 在一些实施方案中，支架是可在导丝上传送的可扩张或自扩张支架。 限流构件可以包括在展开之后可以关闭的阀。 在展开时，支架和限流构件可以接合体腔内腔的内表面，阻止材料的流动。 在一些实施例中，体腔是血管，并且该装置可用于阻止血液流动。 在一些实施方案中，该装置包括生物活性剂。

公开(公告)号：US20070255388A1

公开(公告)日：2007-11-01

申请号：US11786023

申请日：2007-04-09

申请人： Leon Rudakov ,  Tsui Hong ,  Michael O'Connor

发明人： Leon Rudakov ,  Tsui Hong ,  Michael O'Connor

IPC分类号： A61F2/82

CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/065

摘要： Embodiments of a uniformly porous membrane covering an endoprosthetic device, for example, a stent used to treat an aneurysm, are described. Some embodiments have a pore size and spacing that provides a material ratio of between 70-80% in the deployed state. Material ratio is the proportion of the total porous segment of the membrane that corresponds to membrane material, the remainder being pores. In some embodiments, pore size ranges from about 10-100 μm. In some embodiments, pores are equidistantly spaced with pore spacing in a range of about 40-100 μm. The combination of pore size and spacing are effective to provide a membrane that substantially prevents flow to the aneurysm, while maintaining flow to perforator vessels. In some embodiments the membrane includes permanently attached agents that promote attachment of endothelial cells or progenitors and healing of the aneurysm, or reduce immune responses detrimental to the healing process.

摘要翻译： 描述了覆盖假体内装置的均匀多孔膜的实施例，例如用于治疗动脉瘤的支架。 一些实施例具有在展开状态下提供70-80％之间的材料比的孔径和间距。 材料比是对应于膜材料的膜的总多孔段的比例，其余是孔。 在一些实施方案中，孔径范围为约10-100μm。 在一些实施方案中，孔等距离地间隔开约40-100μm的范围内的孔隙。 孔径和间距的组合对于提供基本上防止流动到动脉瘤同时保持向穿孔器容器流动的膜是有效的。 在一些实施方案中，膜包括促进内皮细胞或祖细胞的附着和动脉瘤愈合的永久附着的试剂，或降低对愈合过程有害的免疫应答。