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19 条记录 (耗时 0.02 秒)

    Native-state histoculturing skin extracellular support
    2.
    发明授权
    Native-state histoculturing skin extracellular support 失效
    天然组织培养皮肤细胞外支持

    公开(公告)号：US06399380B1

    公开(公告)日：2002-06-04

    申请号：US09211480

    申请日：1998-12-14

    申请人： Lingna Li

    发明人： Lingna Li

    IPC分类号： C12N500

    CPC分类号： C12N5/0629 ,  C12N2503/00 ,  C12N2533/54

    摘要： Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal surface of the skin is adjacent to the matrix and the external surface is exposed above the surface of the medium and the skin maintained in the medium under skin culturing conditions. An extracellular support matrix comprising a collagen-containing gel and homopolysaccharide sponge or a combination matrix of a top layer of a collagen-containing gel and a bottom layer of a homopolysaccharide sponge is also disclosed. Skin toxicity, hair growth, anti-aging and anti-wrinkling assays utilizing the histoculturing system of the present invention are also disclosed.

    摘要翻译： 公开了用于皮肤的天然状态组织培养系统的方法和组合物。 将皮肤样品放置在浸在培养基中的细胞外支持基质上，由此皮肤的内表面与基质相邻，并且外表面暴露在培养基表面之上，皮肤在皮肤培养条件下保持在培养基中。 还公开了包含含胶原蛋白的凝胶和均聚多糖海绵的细胞外支持基质或含有胶原的凝胶的顶层和均聚糖海绵的底层的组合基质。 还公开了利用本发明的组织培养系统的皮肤毒性，毛发生长，抗衰老和抗皱纹测定。

    Method to provide for production of hair coloring pigments in hair follicles
    3.
    发明授权
    Method to provide for production of hair coloring pigments in hair follicles 失效
    提供毛发中着色颜料的生产方法

    公开(公告)号：US06261596B1

    公开(公告)日：2001-07-17

    申请号：US09316763

    申请日：1999-05-21

    申请人： Lingna Li ,  Valeryi Lishko

    发明人： Lingna Li ,  Valeryi Lishko

    IPC分类号： A61K706

    CPC分类号： C12Y110/03001 ,  A61K8/14 ,  A61K8/606 ,  A61K8/72 ,  A61K9/127 ,  A61K48/00 ,  A61Q5/10 ,  A61Q7/00 ,  B82Y5/00 ,  C12N9/0059 ,  C12N9/0071 ,  C12N9/2468 ,  C12Y114/18001

    摘要： The present invention describes a method for targeted and specific delivery of beneficial compounds, including hair dyes, melanin, proteins, and nucleic acids for gene therapy, to hair follicle cells using liposomes encapsulating the beneficial compound. Particularly preferred methods describe delivery of hair dyes, melanin or tyrosinase to the hair follicle for the purpose of improving hair color or condition, the delivery of compounds which prevent alopecia or stimulate hair growth, either by encapsulating a compound in liposomes, or by encapsulating a nucleic acid capable of expressing a protein in liposomes. Also described are liposome compositions for practicing the methods.

    摘要翻译： 本发明描述了使用包封有益化合物的脂质体将有益化合物（包括毛发染料，黑色素，蛋白质和用于基因治疗的核酸）靶向和特异性递送至毛囊细胞的方法。 特别优选的方法描述了将染发剂，黑色素或酪氨酸酶递送到毛囊中，以改善毛发颜色或状况，通过将化合物包封在脂质体中来防止脱发或刺激毛发生长的化合物的递送，或通过包封 能够在脂质体中表达蛋白质的核酸。 还描述了用于实施该方法的脂质体组合物。

    Method for promoting hair growth
    5.
    发明授权
    Method for promoting hair growth 失效
    促进头发生长的方法

    公开(公告)号：US07556825B2

    公开(公告)日：2009-07-07

    申请号：US10840908

    申请日：2004-05-07

    申请人： Lingna Li ,  Valeryi Lishko

    发明人： Lingna Li ,  Valeryi Lishko

    IPC分类号： A61K9/127 ,  A61K7/13

    CPC分类号： C12Y110/03001 ,  A61K8/14 ,  A61K8/606 ,  A61K8/72 ,  A61K9/127 ,  A61K48/00 ,  A61Q5/10 ,  A61Q7/00 ,  C12N9/0059 ,  C12N9/0071 ,  C12N9/2471 ,  C12Y114/18001 ,  C12Y302/01023

    摘要： The present invention describes a method for targeted and specific delivery of beneficial compounds, including hair dyes, melanin, proteins, and nucleic acids for gene therapy, to hair follicle cells using liposomes encapsulating the beneficial compound. Particularly preferred methods describe delivery of hair dyes, melanin or tyrosinase to the hair follicle for the purpose of improving hair color or condition, the delivery of compounds which prevent alopecia or stimulate hair growth, either by encapsulating a compound in liposomes, or by encapsulating a nucleic acid capable of expressing a protein in liposomes. Also described are liposome compositions for practicing the methods.

    摘要翻译： 本发明描述了使用包封有益化合物的脂质体将有益化合物（包括毛发染料，黑色素，蛋白质和用于基因治疗的核酸）靶向和特异性递送至毛囊细胞的方法。 特别优选的方法描述了将染发剂，黑色素或酪氨酸酶递送到毛囊中，以改善毛发颜色或状况，通过将化合物包封在脂质体中来防止脱发或刺激毛发生长的化合物的递送，或通过包封 能够在脂质体中表达蛋白质的核酸。 还描述了用于实施该方法的脂质体组合物。

    Angiogensis models using nestin-expressing stem cells to image nascent blood vessels
    9.
    发明授权
    Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效
    使用巢蛋白表达干细胞来形成新生血管的血管生成模型

    公开(公告)号：US08778308B2

    公开(公告)日：2014-07-15

    申请号：US10977219

    申请日：2004-10-28

    申请人： Yasuyuki Amoh ,  Lingna Li ,  Meng Yang ,  Ping Jiang

    发明人： Yasuyuki Amoh ,  Lingna Li ,  Meng Yang ,  Ping Jiang

    IPC分类号： A61B5/00 ,  G01N21/64 ,  G01N33/50

    CPC分类号： G01N33/5073

    摘要： The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.

    摘要翻译： 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物，特别是肿瘤相关血管发生。 具体来说，巢蛋白作为脑肿瘤如胶质瘤，血管母细胞瘤，神经鞘瘤，成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此，所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。

    Nestin-expressing hair follicle stem cells
    10.
    发明授权
    Nestin-expressing hair follicle stem cells 失效
    巢蛋白表达的毛囊干细胞

    公开(公告)号：US07666675B2

    公开(公告)日：2010-02-23

    申请号：US10251657

    申请日：2002-09-20

    申请人： Lingna Li ,  Meng Yang

    发明人： Lingna Li ,  Meng Yang

    IPC分类号： A01N63/00 ,  A61K48/00 ,  A01K67/027 ,  C12N5/00 ,  C12N5/02

    CPC分类号： C12N5/0661 ,  A61K35/12 ,  C12N5/0619 ,  C12N5/0622 ,  C12N5/0628 ,  C12N2501/13 ,  C12N2501/135 ,  C12N2506/092

    摘要： Hair follicle stem cells are isolated from mammals by isolating nestin-expressing cells. These hair follicle stem cells are a source of adult stem cells for autologous or heterologous stem cell therapy. The stem cells can be systemically implanted into the mammal or directly implanted into the organ. In addition, the stem cells may be further differentiated in vitro and then implanted systemically or directly into the mammal.

    摘要翻译： 通过分离巢蛋白表达细胞从哺乳动物中分离毛囊干细胞。 这些毛囊干细胞是用于自体或异源干细胞治疗的成体干细胞的来源。 干细胞可全身植入哺乳动物或直接植入器官。 此外，干细胞可以在体外进一步分化，然后系统地或直接植入哺乳动物。