Angiogensis models using nestin-expressing stem cells to image nascent blood vessels
    1.
    发明授权
    Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效
    使用巢蛋白表达干细胞来形成新生血管的血管生成模型

    公开(公告)号:US08778308B2

    公开(公告)日:2014-07-15

    申请号:US10977219

    申请日:2004-10-28

    IPC分类号: A61B5/00 G01N21/64 G01N33/50

    CPC分类号: G01N33/5073

    摘要: The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.

    摘要翻译: 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物,特别是肿瘤相关血管发生。 具体来说,巢蛋白作为脑肿瘤如胶质瘤,血管母细胞瘤,神经鞘瘤,成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此,所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。

    Angiogensis models using nestin-expressing stem cells to image nascent blood vessels
    2.
    发明申请
    Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效
    使用巢蛋白表达干细胞来形成新生血管的血管生成模型

    公开(公告)号:US20050170330A1

    公开(公告)日:2005-08-04

    申请号:US10977219

    申请日:2004-10-28

    CPC分类号: G01N33/5073

    摘要: The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.

    摘要翻译: 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物,特别是肿瘤相关血管发生。 具体来说,巢蛋白作为脑肿瘤如胶质瘤,血管母细胞瘤,神经鞘瘤,成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此,所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。

    Nestin-expressing hair follicle stem cells
    3.
    发明授权
    Nestin-expressing hair follicle stem cells 失效
    巢蛋白表达的毛囊干细胞

    公开(公告)号:US07666675B2

    公开(公告)日:2010-02-23

    申请号:US10251657

    申请日:2002-09-20

    申请人: Lingna Li Meng Yang

    发明人: Lingna Li Meng Yang

    摘要: Hair follicle stem cells are isolated from mammals by isolating nestin-expressing cells. These hair follicle stem cells are a source of adult stem cells for autologous or heterologous stem cell therapy. The stem cells can be systemically implanted into the mammal or directly implanted into the organ. In addition, the stem cells may be further differentiated in vitro and then implanted systemically or directly into the mammal.

    摘要翻译: 通过分离巢蛋白表达细胞从哺乳动物中分离毛囊干细胞。 这些毛囊干细胞是用于自体或异源干细胞治疗的成体干细胞的来源。 干细胞可全身植入哺乳动物或直接植入器官。 此外,干细胞可以在体外进一步分化,然后系统地或直接植入哺乳动物。

    Cancer selective auxotrophs
    10.
    发明申请
    Cancer selective auxotrophs 有权
    癌症选择性营养缺陷型

    公开(公告)号:US20090300779A1

    公开(公告)日:2009-12-03

    申请号:US11631247

    申请日:2005-06-29

    申请人: Ming Zhao Meng Yang

    发明人: Ming Zhao Meng Yang

    摘要: Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.

    摘要翻译: 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗,标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。