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1.发明授权Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效使用巢蛋白表达干细胞来形成新生血管的血管生成模型公开(公告)号：US08778308B2
公开(公告)日：2014-07-15
申请号：US10977219
申请日：2004-10-28
申请人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
发明人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
CPC分类号： G01N33/5073
摘要： The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.
摘要翻译： 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物，特别是肿瘤相关血管发生。 具体来说，巢蛋白作为脑肿瘤如胶质瘤，血管母细胞瘤，神经鞘瘤，成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此，所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。
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2.发明申请Angiogensis models using nestin-expressing stem cells to image nascent blood vessels 失效使用巢蛋白表达干细胞来形成新生血管的血管生成模型公开(公告)号：US20050170330A1
公开(公告)日：2005-08-04
申请号：US10977219
申请日：2004-10-28
申请人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
发明人： Yasuyuki Amoh , Lingna Li , Meng Yang , Ping Jiang
IPC分类号： A01K67/027 , A01N63/00 , C12Q1/00 , G01N33/50
CPC分类号： G01N33/5073
摘要： The disclosed invention relates to the observation that nestin expression is a marker for endothelial cell proliferation. Nestin expression is particularly useful as a marker for angiogenesis, particularly for tumor-related angiogenesis. Specifically, nestin serves as an excellent endothelium marker for brain tumors such as gliomas, hemangioblastomas, Schwannomas, medulloblastomas, and meningiomas. Accordingly, the disclosed invention relates to the use of this marker as a basis to model angiogenic activity.
摘要翻译： 所公开的发明涉及巢蛋白表达是内皮细胞增殖的标志物的观察。 巢蛋白表达特别可用作血管发生的标志物，特别是肿瘤相关血管发生。 具体来说，巢蛋白作为脑肿瘤如胶质瘤，血管母细胞瘤，神经鞘瘤，成神经管细胞瘤和脑膜瘤的优异内皮标志物。 因此，所公开的发明涉及该标记物作为模型血管生成活性的基础的用途。
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公开(公告)号：US07666675B2
公开(公告)日：2010-02-23
申请号：US10251657
申请日：2002-09-20
IPC分类号： A01N63/00 , A61K48/00 , A01K67/027 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0661 , A61K35/12 , C12N5/0619 , C12N5/0622 , C12N5/0628 , C12N2501/13 , C12N2501/135 , C12N2506/092
摘要： Hair follicle stem cells are isolated from mammals by isolating nestin-expressing cells. These hair follicle stem cells are a source of adult stem cells for autologous or heterologous stem cell therapy. The stem cells can be systemically implanted into the mammal or directly implanted into the organ. In addition, the stem cells may be further differentiated in vitro and then implanted systemically or directly into the mammal.
摘要翻译： 通过分离巢蛋白表达细胞从哺乳动物中分离毛囊干细胞。 这些毛囊干细胞是用于自体或异源干细胞治疗的成体干细胞的来源。 干细胞可全身植入哺乳动物或直接植入器官。 此外，干细胞可以在体外进一步分化，然后系统地或直接植入哺乳动物。
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公开(公告)号：US08481318B2
公开(公告)日：2013-07-09
申请号：US12694213
申请日：2010-01-26
CPC分类号： C12N5/0661 , A61K35/12 , C12N5/0619 , C12N5/0622 , C12N5/0628 , C12N2501/13 , C12N2501/135 , C12N2506/092
摘要： Hair follicle stem cells are isolated in a method which relies on the identification of stem cells as being small, spindle, oval or round shaped nestin-expressing cells that are located in the permanent upper part of telogen hair follicles below the sebaceous glands and in the bulge area.
摘要翻译： 分离毛囊干细胞的方法，其依赖于将干细胞鉴定为位于皮脂腺下面的休止期毛囊的永久上部的小的，纺锤形，椭圆形或圆形的巢蛋白表达细胞，并且在 凸起区域。
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公开(公告)号：US20100159589A1
公开(公告)日：2010-06-24
申请号：US12694213
申请日：2010-01-26
IPC分类号： C12N5/079 , C12N5/0789 , C12N5/0793
CPC分类号： C12N5/0661 , A61K35/12 , C12N5/0619 , C12N5/0622 , C12N5/0628 , C12N2501/13 , C12N2501/135 , C12N2506/092
摘要： Hair follicle stem cells are isolated by virtue of understanding their location within the hair follicle during telogen phase.
摘要翻译： 通过了解它们在休眠期期间在毛囊内的位置，分离出毛囊干细胞。
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公开(公告)号：US06905831B2
公开(公告)日：2005-06-14
申请号：US10643785
申请日：2003-08-18
申请人： Ping Jiang , Mingxu Xu , Meng Yang
发明人： Ping Jiang , Mingxu Xu , Meng Yang
IPC分类号： G01N21/78 , C12N20060101 , C12N5/00 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/68
CPC分类号： G01N33/5088 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N33/574 , G01N33/6875
摘要： Living cells can be stably modified to emit different colors from the cytoplasm and nucleus, thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally-aided observation. These observations may be made, if desired, in real time. In addition, rates of proliferation and drug sensitivities can be determined in vitro in real time by the use of cells modified to express a single fluorescent protein and observing fluorescence intensity as a function of time.
摘要翻译： 可以稳定地修饰活细胞以从细胞质和细胞核发射不同的颜色，从而通过视觉或仪器辅助观察来分析所述细胞的状态和药剂对所述细胞的作用。 如果需要，可以实时地进行这些观察。 此外，通过使用修饰以表达单个荧光蛋白并观察作为时间的函数的荧光强度的细胞，可以体外测定体外增殖和药物敏感性的速率。
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公开(公告)号：US08148600B2
公开(公告)日：2012-04-03
申请号：US10775554
申请日：2004-02-09
申请人： Meng Yang , Eligio Reynoso , Mingxu Xu , Ping Jiang
发明人： Meng Yang , Eligio Reynoso , Mingxu Xu , Ping Jiang
IPC分类号： A01K67/027 , A01K67/02
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/43595 , C12N15/8509
摘要： Immunocompromised rodents that have been modified to express a fluorescent protein in substantially all tissues are described. These rodents are useful as models for gene expression, tumor progression and angiogenesis. Also provided are model systems where heterologous tissues fluorescing in a first color are transplanted into hosts that have been modified to fluoresce in substantially all tissues with a second color.
摘要翻译： 描述了已在基本上所有组织中修饰以表达荧光蛋白的免疫受损啮齿动物。 这些啮齿动物可用作基因表达，肿瘤进展和血管发生的模型。 还提供了模型系统，其中以第一种颜色发荧光的异源组织移植到已被修饰为在基本上具有第二种颜色的所有组织中发荧光的宿主中。
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公开(公告)号：US20080038204A1
公开(公告)日：2008-02-14
申请号：US10587528
申请日：2005-01-26
申请人： Meng Yang , Ping Jiang
发明人： Meng Yang , Ping Jiang
IPC分类号： A61B5/00
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/415 , A61B5/418 , G01N21/6447
摘要： Methods to image a fluorescent protein in intact subjects using simple portable instruments are described.
摘要翻译： 描述了使用简单便携式仪器对完整受试者中的荧光蛋白进行成像的方法。
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公开(公告)号：US20090300779A1
公开(公告)日：2009-12-03
申请号：US11631247
申请日：2005-06-29
CPC分类号： A61K35/74 , A61K38/2013 , A61K38/51
摘要： Bacteria that are auxotrophic for at least two amino acids found in at least one tumor are effective anti tumor treatments, labeling agents, and vaccines against infection. Improved antitumor effects can also be provided such strains by passage through an appropriate tumor model.
摘要翻译： 在至少一种肿瘤中发现的至少两种氨基酸营养缺陷型细菌是有效的抗肿瘤治疗，标记试剂和针对感染的疫苗。 也可以通过适当的肿瘤模型通过这些菌株提供改善的抗肿瘤作用。
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