-
1.发明申请Application of electrical stimulation for functional tissue engineering in vitro and in vivo 有权电刺激在体外和体内功能组织工程中的应用公开(公告)号：US20050112759A1
公开(公告)日：2005-05-26
申请号：US10872577
申请日：2004-06-21
IPC分类号： A61F2/00 , A61N20060101 , C12N5/00 , C12N5/077 , C12N5/08
CPC分类号： C12N5/0658 , C12N2502/02 , C12N2502/1358 , C12N2529/00
摘要： The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
摘要翻译： 本发明提供了体外制备生物人造组织当量的新方法及其在体内植入后的增强整合。 这些方法包括在体外培养过程中将组织构建物递送至仿生电刺激，以改善其结构和功能性质，和/或在植入该构建体后体内，以增强其与宿主组织的整合并增加细胞存活和功能。 本发明的方法特别可用于生产生物人造等同物和/或修复和替换含有电可兴奋细胞的天然组织，并且在体内受到电刺激，例如心肌组织，条纹骨骼肌组织 ，平滑肌肉组织，骨骼，脉管系统和神经组织。
-
公开(公告)号：US20050037952A1
公开(公告)日：2005-02-17
申请号：US10457248
申请日：2003-06-09
申请人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
发明人： Lisa Freed , Keith Gooch , Donald Courter , Torsten Blunk , Alisha Sieminski , Gordana Vunjak-Novakovic
CPC分类号： A61L27/3817 , A61L27/18 , A61L27/227 , A61L27/3654 , A61L27/3852 , A61L27/54 , A61L2300/414 , A61L2430/06 , C08L67/04
摘要： Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.
摘要翻译： 公开了包含至少一种选自TGF-β超家族蛋白（包括BMP）的活性剂和用于增加生长速率或调节工程化软骨发育的GDF的组合物和方法。 该组合物可用于治疗骨关节炎，软骨缺损和相关组织修复。
-
3.发明授权Application of electrical stimulation for functional tissue engineering in vitro and in vivo 有权电刺激在体外和体内功能组织工程中的应用公开(公告)号：US08367410B2
公开(公告)日：2013-02-05
申请号：US10872577
申请日：2004-06-21
CPC分类号： C12N5/0658 , C12N2502/02 , C12N2502/1358 , C12N2529/00
摘要： The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.
摘要翻译： 本发明提供了体外制备生物人造组织当量的新方法及其在体内植入后的增强整合。 这些方法包括在体外培养过程中将组织构建物递送至仿生电刺激，以改善其结构和功能性质，和/或在植入该构建体后体内，以增强其与宿主组织的整合并增加细胞存活和功能。 本发明的方法特别可用于生产生物人造等同物和/或修复和替换含有电可兴奋细胞的天然组织，并且在体内受到电刺激，例如心肌组织，条纹骨骼肌组织 ，平滑肌肉组织，骨骼，脉管系统和神经组织。
-
-
搜索结果
3 条记录 (耗时 0.01 秒)
