公开(公告)号：US09278296B2

公开(公告)日：2016-03-08

申请号：US13990160

申请日：2011-11-28

Applicant: Manoj Kumar Ramakrishna ,  Shashikanth Agnihotry

Inventor： Manoj Kumar Ramakrishna ,  Shashikanth Agnihotry

IPC: B01D15/22 ,  G01N30/60

CPC classification number: B01D15/22 ,  G01N30/6004 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6052 ,  Y10T29/49826 ,  Y10T29/49883

Abstract: The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate.

Abstract translation: 本发明涉及将分配器板固定到色谱柱的背板的方法，而不需要可释放的固定装置作为螺钉或螺栓。 本发明还涉及利用这种方法的色谱柱。 该方法采用在柱内部产生的负压或真空，以将分配器固定到背板。

公开(公告)号：US08668829B2

公开(公告)日：2014-03-11

申请号：US13703388

申请日：2011-06-16

Applicant: Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

Inventor： Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

IPC: B01D15/08

CPC classification number: B01D15/10 ,  B01D15/22 ,  G01N30/56 ,  Y10T29/49721

Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of: a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).

Abstract translation: 一种用于在色谱柱（1; 41）上进行维护的方法，包括以下步骤：a）当需要维护时，将色谱柱的底板（5; 53）与可分离的接头（7; 63） （3; 43），其上提供色谱柱; b）将色谱系统中提供的适配器（15; 59）连接到色谱柱（1; 41）的任何部分，使得可以将底板（5; 53）从支架（3; 43） 适配器（15; 59）; 以及c）升高所述适配器（15; 59），从而也提升所述底板（5; 53），使得能够在所述底板（5; 53）下进行维护。

公开(公告)号：US20130240426A1

公开(公告)日：2013-09-19

申请号：US13990160

申请日：2011-11-28

Applicant: Manoj Kumar Ramakrishna ,  Shashikanth Agnihotry

Inventor： Manoj Kumar Ramakrishna ,  Shashikanth Agnihotry

IPC: B01D15/22

CPC classification number: B01D15/22 ,  G01N30/6004 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6026 ,  G01N30/6047 ,  G01N30/6052 ,  Y10T29/49826 ,  Y10T29/49883

Abstract: The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum that is generated internally within the column to affix the distributor to the backing plate.

Abstract translation: 本发明涉及将分配器板固定到色谱柱的背板的方法，而不需要可释放的固定装置作为螺钉或螺栓。 本发明还涉及利用这种方法的色谱柱。 该方法采用在柱内部产生的负压或真空，以将分配器固定到背板。

公开(公告)号：US09943781B2

公开(公告)日：2018-04-17

申请号：US13701251

申请日：2011-06-01

Applicant: Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

Inventor： Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

IPC: B01D15/22 ,  B01D15/18 ,  G01N30/46 ,  F16L55/00 ,  G01N30/60

CPC classification number: B01D15/22 ,  B01D15/1864 ,  B01D15/1885 ,  F16L55/00 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6004 ,  Y10T29/49826

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US20130087491A1

公开(公告)日：2013-04-11

申请号：US13703388

申请日：2011-06-16

Applicant: Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

Inventor： Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

IPC: B01D15/10 ,  B01D15/22

CPC classification number: B01D15/10 ,  B01D15/22 ,  G01N30/56 ,  Y10T29/49721

Abstract: A method for performing maintenance on a chromatography column (1; 41) comprising the steps of:a) when maintenance is required, detaching a detachable joint (7; 63) between a bottom plate (5; 53) of the chromatography column and a stand (3; 43) on which the chromatography column is provided; b) attaching an adaptor (15; 59) provided in the chromatography system to any part of the chromatography column (1; 41) making it possible to lift the bottom plate (5; 53) from the stand (3; 43) with the adaptor (15; 59); and c) raising the adaptor (15; 59) and thereby also the bottom plate (5; 53) such that maintenance can be performed under the bottom plate (5; 53).

Abstract translation: 一种用于在色谱柱（1; 41）上进行维护的方法，包括以下步骤：a）当需要维护时，将色谱柱的底板（5; 53）与可分离的接头（7; 63） （3; 43），其上提供色谱柱; b）将色谱系统中提供的适配器（15; 59）连接到色谱柱（1; 41）的任何部分，使得可以将底板（5; 53）从支架（3; 43） 适配器（15; 59）; 以及c）升高所述适配器（15; 59），从而也提升所述底板（5; 53），使得能够在所述底板（5; 53）下进行维护。

公开(公告)号：US20130068671A1

公开(公告)日：2013-03-21

申请号：US13701251

申请日：2011-06-01

Applicant: Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

Inventor： Klaus Gebauer ,  Manoj Kumar Ramakrishna ,  Daniel Salomonsson ,  Per Uselius

IPC: B01D15/22 ,  F16L55/00

CPC classification number: B01D15/22 ,  B01D15/1864 ,  B01D15/1885 ,  F16L55/00 ,  G01N30/461 ,  G01N30/466 ,  G01N30/6004 ,  Y10T29/49826

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Abstract translation: 连接在刚性壳体（21; 61）中的色谱柱模块（3a，b，c; 13a，b，c; 53a，b，c，90a，b）的平行组件（2; 11; 51） 具有一个共同的组装入口（15; 55）和一个公共组件出口（17; 57），每个柱模块包括填充有色谱介质的床空间（29），并且每个柱模块包括集成流体导管，当列模块连接时 其中在刚性壳体中的其它柱模块适于将柱模块的床空间（29）与组件入口（15; 55）和组件出口（17; 57）连接，其中总长度和/ 从组装入口到一个床空间的流体导管以及流体导管从同一床空间到组件出口的长度和/或体积与安装在平行组件中的所有床空间和模块基本相同。