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公开(公告)号：US20100048481A1
公开(公告)日：2010-02-25
申请号：US12528071
申请日：2008-02-21
Applicant: Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
Inventor： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
CPC classification number: A61K9/06 , A61K9/0024 , A61K47/42
Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition.This invention is related to a controlled release composition comprising a cross-linked gelatin and at least one therapeutic protein wherein the ratio of the average mesh size (ξ) of the gelatin matrix and the average hydrodynamic radius (RH) of the therapeutic protein is smaller than 2, preferably smaller than 1.5.
Abstract translation: 本发明涉及药理学领域。 更具体地，本发明涉及控释组合物。 本发明涉及包含交联明胶和至少一种治疗性蛋白质的控释组合物，其中明胶基质的平均筛网尺寸（＆amp; xgr）与治疗性蛋白质的平均流体动力学半径（RH）之比为 小于2，优选小于1.5。
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公开(公告)号：US20160326084A1
公开(公告)日：2016-11-10
申请号：US15107855
申请日：2014-12-24
Applicant: Marc LEMAIRE , Estelle METAY , Marc SUTTER , Yann RAOUL , Eric DA SILVA , Sophie SAMBOU , Philippe BLACH , Avril , Oleon SA , Université Claude Bernard Lyon 1 , Centre National de la Recherche Scientifique (CNRS)
Inventor： Marc Lemaire , Estelle Metay , Marc Sutter , Yann Raoul , Eric Da Silva , Sophie Sambou , Philippe Blach
IPC: C07C51/245 , C07C67/333 , C07C51/25 , C07C51/353 , C08K5/101 , C08K5/11 , C08K5/09 , C08K5/092 , C09J11/06 , A61K8/37 , A61K8/36 , A61K8/362 , A01N37/02 , B01J21/08 , B01J21/04 , B01J37/08 , C10M129/42 , C10M129/40 , A23L33/10 , C07C67/30
CPC classification number: C07C51/245 , A01N37/02 , A23L33/10 , A23V2002/00 , A61K8/361 , A61K8/362 , A61K8/37 , B01J21/04 , B01J21/08 , B01J37/08 , C07C51/23 , C07C51/25 , C07C51/353 , C07C67/30 , C07C67/333 , C08K5/09 , C08K5/092 , C08K5/101 , C08K5/11 , C09J11/06 , C10M129/40 , C10M129/42 , C10M2207/126 , C10M2207/127 , C07C53/126 , C07C69/48
Abstract: A process for preparing a carboxylic acid, including a step of bringing at least one vicinal diol or at least one vicinal polyol into contact with an atmosphere including oxygen, and a catalyst, and in the absence of additional solvent.
Abstract translation: 一种制备羧酸的方法，包括使至少一种邻位二醇或至少一个邻位多元醇与包含氧气和催化剂的气氛以及在不存在另外的溶剂的情况下接触的步骤。
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Patent Agency Ranking
公开(公告)号：US08912365B2
公开(公告)日：2014-12-16
申请号：US13993980
申请日：2011-12-16
Applicant: Marc Lemaire , Wissam Dayoub , Marc Sutter , Yann Raoul
Inventor： Marc Lemaire , Wissam Dayoub , Marc Sutter , Yann Raoul
CPC classification number: C07C41/00 , C07C41/01 , C07C43/135 , C07C43/13
Abstract: The present invention relates to a process for preparing a polyol ether of formula (I), comprising a step of reductive alkylation involving a compound of general formula (II) and a compound of general formula (III): in which R1, R2, R3 and R4 are as defined in claim 1.
Abstract translation: 本发明涉及一种制备式（I）的多元醇醚的方法，其包括通式（II）的化合物和通式（III）的化合物的还原性烷基化步骤：其中R 1，R 2，R 3 和R 4如权利要求1所定义。
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公开(公告)号：US08101205B2
公开(公告)日：2012-01-24
申请号：US12528071
申请日：2008-02-21
Applicant: Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
Inventor： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
IPC: A61K9/26
CPC classification number: A61K9/06 , A61K9/0024 , A61K47/42
Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition.This invention is related to a controlled release composition comprising a cross-linked gelatin and at least one therapeutic protein wherein the ratio of the average mesh size (ξ) of the gelatin matrix and the average hydrodynamic radius (RH) of the therapeutic protein is smaller than 2, preferably smaller than 1.5.
Abstract translation: 本发明涉及药理学领域。 更具体地说，本发明涉及控释组合物。 本发明涉及包含交联明胶和至少一种治疗性蛋白质的控释组合物，其中明胶基质的平均筛网尺寸（＆amp; xgr）与治疗性蛋白质的平均流体动力学半径（RH）之比为 小于2，优选小于1.5。
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公开(公告)号：US08357397B2
公开(公告)日：2013-01-22
申请号：US12528060
申请日：2008-02-21
Applicant: Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
Inventor： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
IPC: A61K9/26
CPC classification number: A61L27/54 , A61K9/06 , A61K9/1658 , A61K38/47 , A61K47/42 , A61L15/32 , A61L15/44 , A61L27/222 , A61L27/60 , A61L2300/252 , A61L2300/602
Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. In one of the embodiments, the invention provides a method for preparing a controlled release composition comprising the steps of: providing a mixture of a recombinant gelatin and a pharmaceutical chemically cross-linking said recombinant gelatin to obtain a three dimensional network structure.
Abstract translation: 本发明涉及药理学领域。 更具体地说，本发明涉及控释组合物。 在一个实施方案中，本发明提供了一种制备控释组合物的方法，其包括以下步骤：提供重组明胶和化学交联所述重组明胶的药物的混合物以获得三维网状结构。
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公开(公告)号：US20140018579A1
公开(公告)日：2014-01-16
申请号：US13993980
申请日：2011-12-16
Applicant: Marc Lemaire , Wissam Dayoub , Marc Sutter , Yann Raoul
Inventor： Marc Lemaire , Wissam Dayoub , Marc Sutter , Yann Raoul
IPC: C07C41/00
CPC classification number: C07C41/00 , C07C41/01 , C07C43/135 , C07C43/13
Abstract: The present invention relates to a process for preparing a polyol ether of formula (I), comprising a step of reductive alkylation involving a compound of general formula (II) and a compound of general formula (III): in which R1, R2, R3 and R4 are as defined in claim 1.
Abstract translation: 本发明涉及一种制备式（I）的多元醇醚的方法，其包括通式（II）的化合物和通式（III）的化合物的还原性烷基化步骤：其中R 1，R 2，R 3 和R 4如权利要求1所定义。
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公开(公告)号：US20100203138A1
公开(公告)日：2010-08-12
申请号：US12528060
申请日：2008-02-21
Applicant: Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
Inventor： Jan Bastiaan Bouwstra , Marc Sutter , Sebastianus Gerardus Kluijtmans , Wilhelmus Everhardus Hennink , Wim Jiskoot
CPC classification number: A61L27/54 , A61K9/06 , A61K9/1658 , A61K38/47 , A61K47/42 , A61L15/32 , A61L15/44 , A61L27/222 , A61L27/60 , A61L2300/252 , A61L2300/602
Abstract: The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. In one of the embodiments, the invention provides a method for preparing a controlled release composition comprising the steps of: providing a mixture of a recombinant gelatin and a pharmaceutical chemically cross-linking said recombinant gelatin to obtain a three dimensional network structure.
Abstract translation: 本发明涉及药理学领域。 更具体地说，本发明涉及控释组合物。 在一个实施方案中，本发明提供了一种制备控释组合物的方法，其包括以下步骤：提供重组明胶和化学交联所述重组明胶的药物的混合物以获得三维网状结构。
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