公开(公告)号：US5669378A

公开(公告)日：1997-09-23

申请号：US576816

申请日：1995-12-21

申请人： Ivo Pera ,  Francesco Merante ,  Marco Cecchini

发明人： Ivo Pera ,  Francesco Merante ,  Marco Cecchini

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0033 ,  A61M2202/064

摘要： A monodose disposable inhaling device is disclosed which is suitable for delivery, via the respiratory tract, therapeutic medication, which includes among its objects and advantages increased convenience in medication with dry medicaments in powder form, especially with respect to accuracy of dosage and accurate placement of the drug. In one embodiment the inhaler device generally consists of a body member having a delivery portion constructed integral with a housing portion, a button member, a spring member and a spring and capsule support member. Additionally, a screen member can be disposed within the body member at the intersection of the delivery portion and the housing portion.

摘要翻译： 公开了一种单剂量一次性吸入装置，其适用于通过呼吸道递送治疗药物，其包括其目的和优点，增加了以粉末形式的干性药物的药物治疗的便利性，特别是关于剂量的准确性和准确的放置 毒品。 在一个实施例中，吸入器装置通常由具有与壳体部分，按钮构件，弹簧构件和弹簧和胶囊支撑构件一体构成的输送部分的主体构件组成。 此外，屏幕构件可以在输送部分和壳体部分的交叉点处设置在主体构件内。

公开(公告)号：US08794232B2

公开(公告)日：2014-08-05

申请号：US11574868

申请日：2004-09-16

申请人： Giampiero Cossi ,  Mario La Barbera ,  Marco Cecchini

发明人： Giampiero Cossi ,  Mario La Barbera ,  Marco Cecchini

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0021

摘要： A monodose inhaler for powdered medicaments consists of a hollow substantially pipe-shaped body that has a first portion (H), for housing a capsule or cartridge of powdered medicament, defined by a wall (W) in which there are formed slots (S) as air intakes to an inner region where the powder drops, and a second portion (M) connected to the first portion (H) for delivering the medicament by means of a primary stream (F) that carries the powder from the drop region along a delivery duct (D) whose end is suitable to be placed in the patient's mouth, and it further includes a secondary duct (D′) located under the delivery duct (D) and provided with its own air intake (S′) for delivering a powderless secondary stream (F′).

摘要翻译： 用于粉末药物的单剂量吸入器由中空的大致管状体构成，其具有第一部分（H），用于容纳由其中形成有槽（S）的壁（W）限定的粉末状药物的胶囊或药筒， 随着空气进​​入到粉末滴下的内部区域，以及连接到第一部分（H）的第二部分（M），用于通过沿着沿着一个第二部分 输送管道（D），其端部适于放置在患者口中，并且还包括位于输送管道（D）下方并设置有自己的进气口（S'）的辅助管道（D'），用于输送 无粉末二次流（F'）。

公开(公告)号：US08393356B2

公开(公告)日：2013-03-12

申请号：US12670821

申请日：2008-07-21

申请人： Fabio Beltram ,  Roberto Cingolani ,  Marco Cecchini ,  Salvatore Girardo ,  Dario Pisignano

发明人： Fabio Beltram ,  Roberto Cingolani ,  Marco Cecchini ,  Salvatore Girardo ,  Dario Pisignano

IPC分类号： H02K44/00

CPC分类号： G01N29/222 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/0896 ,  B01L2300/165 ,  B01L2400/0439 ,  B01L2400/0496 ,  B01L2400/082 ,  B82Y30/00 ,  F04B43/046 ,  G01N2291/02836 ,  G01N2291/0423 ,  Y10T137/2196

摘要： A device for controlling fluid motion in a micro/nanofluidic structure of channels by means of surface acoustic waves is described. The device comprises a structured volume of material bearing a predetermined configuration of micro/nanofluidic channels for holding and transferring amounts of fluids adapted to define at least one fluid inlet and at least one fluid outlet and presenting a hydrophobic behaviour for the fluids to be handled and a substrate made of material with piezoelectric properties coupled to the micro/nanofluidic channels.

摘要翻译： 描述了通过表面声波来控制通道的微/纳流体结构中的流体运动的装置。 该装置包括具有预定构型的微/纳流体通道的结构体积的材料，用于保持和传送适于限定至少一个流体入口和至少一个流体出口的流体量并且为待处理的流体呈现疏水性， 由具有耦合到微/纳流道通道的压电特性的材料制成的衬底。

公开(公告)号：US20070215151A1

公开(公告)日：2007-09-20

申请号：US11574868

申请日：2004-09-16

申请人： Giampiero Cossi ,  Mario La Barbera ,  Marco Cecchini

发明人： Giampiero Cossi ,  Mario La Barbera ,  Marco Cecchini

IPC分类号： A61M15/00

CPC分类号： A61M15/0028 ,  A61M15/0021

摘要： A monodose inhaler for powdered medicaments consists of a hollow substantially pipe-shaped body that has a first portion (H), for housing a capsule or cartridge of powdered medicament, defined by a wall (W) in which there are formed slots (S) as air intakes to an inner region where the powder drops, and a second portion (M) connected to the first portion (H) for delivering the medicament by means of a primary stream (F) that carries the powder from the drop region along a delivery duct (D) whose end is suitable to be placed in the patient's mouth, and it further includes a secondary duct (D′) located under the delivery duct (D) and provided with its own air intake (S′) for delivering a powderless secondary stream (F′). This stream (F′) supports and directs the primary stream (F) so that it can climb over the patient's tongue, thus preventing the excessive deposition of the medicament in the oropharingeal cavity and obtaining a greater effectiveness of the treatment thanks to the larger amount of medicament that reaches the lungs. Other advantages of this inhaler are the better separation of the drug from the excipient due to the secondary stream (F′) that hits and directs the primary stream (F), and its low cost thanks to the fact that it can be manufactured in plastic by injection molding with a monolithic structure and therefore can be used as a disposable inhaler.

摘要翻译： 用于粉末药物的单剂量吸入器由中空的大致管状体构成，其具有第一部分（H），用于容纳由其中形成有槽（S）的壁（W）限定的粉末状药物的胶囊或药筒， 随着空气进​​入到粉末滴下的内部区域，以及连接到第一部分（H）的第二部分（M），用于通过沿着沿着一个第二部分 输送管道（D），其端部适于放置在患者口中，并且还包括位于输送管道（D）下方并设置有自己的进气口（S'）的辅助管道（D'），用于输送 无粉末二次流（F'）。 该流（F'）支撑并引导主流（F），使得其可以爬过患者的舌头，从而防止药物在口腔中的过度沉积，并由于较大的量获得更​​大的治疗效果 的药物到达肺部。 这种吸入器的其它优点是由于可以使用塑料制造的第二流（F）和第二流（F）的二次流（F'），因此可以更好地分离药物与赋形剂，并且其低成本。 通过注塑成型具有整体结构，因此可用作一次性吸入器。

公开(公告)号：US20100200092A1

公开(公告)日：2010-08-12

申请号：US12670821

申请日：2008-07-21

申请人： Fabio Beltram ,  Roberto Cingolani ,  Marco Cecchini ,  Salvatore Girardo ,  Dario Pisignano

发明人： Fabio Beltram ,  Roberto Cingolani ,  Marco Cecchini ,  Salvatore Girardo ,  Dario Pisignano

IPC分类号： F15C1/04 ,  G01N29/22

CPC分类号： G01N29/222 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502784 ,  B01L3/502792 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2300/0896 ,  B01L2300/165 ,  B01L2400/0439 ,  B01L2400/0496 ,  B01L2400/082 ,  B82Y30/00 ,  F04B43/046 ,  G01N2291/02836 ,  G01N2291/0423 ,  Y10T137/2196

摘要： Herein described is a device for controlling fluid motion in a micro/nanofluidic structure of channels, comprising: a structured volume of material (30), bearing a predetermined configuration of micro/nanofluidic channels (C) for holding and transferring amounts of fluids, adapted to define at least one fluid inlet (IN) and at least one fluid outlet (OUT), and presenting a hydrophobic behaviour for the fluids to be handled; and a substrate (31) made of material with piezoelectric properties, coupled to the abovementioned configuration of micro/nanofluidic channels, bearing means for active control of the motion of an amount of fluid, including transducer means (T1-T6) which comprise at least one pair of interdigitated electrodes applied on the substrate (31), which are arranged to selectively generate a surface acoustic wave adapted to propagate on the substrate (31) and interact with the amount of fluid. The transducer devices (T1-T6) are arranged in proximity to a fluid outlet (OUT) of the configuration of channels in such a manner to generate a surface acoustic wave propagating from the fluid outlet (OUT) to a fluid inlet (IN) of the abovementioned configuration and, due to the hydrophobic condition in the channel (C) in which an amount of fluid is localised, determine an effective force at the air-liquid interface where the acoustic wave meets the liquid, whereby the motion of the amount of fluid is induced towards the direction opposite to the surface acoustic wave propagation direction.

摘要翻译： 本文描述了一种用于控制通道的微/纳流体结构中的流体运动的装置，包括：结构化体积的材料（30），其具有用于保持和传送流体量的微/纳流体通道（C）的预定构型， 以限定至少一个流体入口（IN）和至少一个流体出口（OUT），并且对待处理的流体呈现疏水性; 以及由具有压电特性的材料制成的衬底（31），其与上述微/纳流体通道结构相结合，用于主动控制一定量流体的运动的轴承装置，包括至少包括换能器装置（T1-T6）的换能器装置 被布置成选择性地生成适于在衬底（31）上传播并与流体量相互作用的表面声波的衬底（31）上的一对叉指电极。 传感器装置（T1-T6）以这样的方式布置在通道构造的流体出口（OUT）附近，以便产生从流体出口（OUT）传播到流体入口（IN）的流体入口 上述构造，并且由于在流体的流量定位的通道（C）中的疏水状态决定了在声波与液体相遇的气液界面处的有效力，由此， 流体被引向与声表面波传播方向相反的方向。