公开(公告)号：US20140169698A1

公开(公告)日：2014-06-19

申请号：US14235570

申请日：2012-07-20

申请人： Marco Stampanoni ,  Zhentian Wang

发明人： Marco Stampanoni ,  Zhentian Wang

IPC分类号： G06T5/50 ,  G06T11/00

CPC分类号： G06T5/50 ,  A61B6/4035 ,  A61B6/4291 ,  A61B6/483 ,  A61B6/484 ,  A61B6/5235 ,  G01N23/06 ,  G01N2223/401 ,  G06T11/003

摘要： An image fusion method combines absorption, differential phase contrast and dark-field (scattering) signals obtained with X-ray phase contrast sensitive techniques, such as an arrangement of gratings. The process fuses the absorption and dark-field signals by principal component analysis. Further the differential phase contrast is merged into the PCA fused image to obtain an edge enhancement effect. Due to its general applicability and its simplicity in usage, the proposed process is usable as a standard method for image fusion scheme using phase contrast imaging, in particular on medical scanners (for instance mammography), inspection at industrial production lines, non-destructive testing, and homeland security.

摘要翻译： 图像融合方法将吸收，微分相位对比和X射线相位对比敏感技术获得的暗场（散射）信号，如光栅排列相结合。 该过程通过主成分分析来融合吸收和暗场信号。 此外，差分相位对比度被合并到PCA融合图像中以获得边缘增强效果。 由于其一般适用性和使用简单性，所提出的方法可用作使用相位成像的图像融合方案的标准方法，特别是在医疗扫描仪（例如乳腺X线照相术）上，在工业生产线上的检查，非破坏性测试 和国土安全。

公开(公告)号：US20130279659A1

公开(公告)日：2013-10-24

申请号：US13993769

申请日：2011-12-09

申请人： Marco Stampanoni ,  Thomas Thüring

发明人： Marco Stampanoni ,  Thomas Thüring

IPC分类号： G06T7/00 ,  G01N23/04

CPC分类号： G06T7/00 ,  A61B6/484 ,  G01N23/04 ,  G06T11/006 ,  G06T2211/424

摘要： High-quality, artifact-free phase contrast images from an object are yielded using an arrangement of gratings. The method suppresses the need of direct image integration and significantly improves the quality of phase contrast images. In comparison with existing techniques, no additional alignment work is needed, nor increased exposure time. On the other hand, the method delivers excellent, direct interpretable information about the phase projection within a radiographic experiment. Due to its general applicability and its simplicity in usage, the method is likely to become a standard method for a variety of 2D imaging applications using gratings arrangements in particular on medical scanners (for instance mammography), inspection at industrial production lines, non-destructive testing, and homeland security.

摘要翻译： 使用光栅的排列产生来自物体的高品质，无伪影的相位对比图像。 该方法抑制了直接图像集成的需要，显着提高了相位图像的质量。 与现有技术相比，不需要额外的对准工作，也不需要增加曝光时间。 另一方面，该方法提供了关于放射学实验中的相位投影的优秀的，直接可解释的信息。 由于其一般适用性和使用简单性，该方法可能成为使用特别是医疗扫描仪（例如乳腺X线照相术）的光栅布置的各种2D成像应用的标准方法，在工业生产线上的检查，非破坏性 测试和国土安全。

公开(公告)号：US20120041679A1

公开(公告)日：2012-02-16

申请号：US13148198

申请日：2010-02-03

申请人： Marco Stampanoni ,  Ziyu Wu ,  Peiping Zhu

发明人： Marco Stampanoni ,  Ziyu Wu ,  Peiping Zhu

IPC分类号： G06F19/00

CPC分类号： G01N23/04 ,  A61B6/00 ,  A61B6/4291 ,  A61B6/484

摘要： Phase sensitive X-ray imaging methods provide substantially increased contrast over conventional absorption based imaging, and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems impairing the wider use of phase contrast in X-ray radiography and tomography. To separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here, an innovative, highly sensitive X-ray tomographic phase contrast imaging approach is presented based on grating interferometry, which extracts the phase contrast signal without the need of phase stepping. Compared to the existing phase step approach, the main advantage of this new method dubbed “reverse projection” is the significantly reduced delivered dose, without degradation of the image quality.

摘要翻译： 相对于常规的基于吸收的成像，相敏X射线成像方法提供了显着增加的对比度，因此提供了新的和其他不可接近的信息。 在硬X射线相位成像中使用光栅作为光学元件克服了在X射线摄影和断层摄影中损害相对对比度的更广泛使用的一些问题。 为了将相位信息与用光栅干涉仪检测到的其他贡献分离，已经考虑了相位步进方法，这意味着获取多个射线照相投影。 在这里，基于光栅干涉测量提出了一种创新的，高灵敏度的X射线断层扫描相位成像方法，其提取相位差信号，而不需要相位步进。 与现有的相位步法相比，这种被称为“反投影”的新方法的主要优点是显着降低了传送剂量，而不会降低图像质量。

公开(公告)号：US09117296B2

公开(公告)日：2015-08-25

申请号：US14235570

申请日：2012-07-20

申请人： Marco Stampanoni ,  Zhentian Wang

发明人： Marco Stampanoni ,  Zhentian Wang

IPC分类号： G06K9/36 ,  G06T5/50 ,  G01N23/06 ,  G06T11/00 ,  A61B6/00

CPC分类号： G06T5/50 ,  A61B6/4035 ,  A61B6/4291 ,  A61B6/483 ,  A61B6/484 ,  A61B6/5235 ,  G01N23/06 ,  G01N2223/401 ,  G06T11/003

摘要： An image fusion method combines absorption, differential phase contrast and dark-field (scattering) signals obtained with X-ray phase contrast sensitive techniques, such as an arrangement of gratings. The process fuses the absorption and dark-field signals by principal component analysis. Further the differential phase contrast is merged into the PCA fused image to obtain an edge enhancement effect. Due to its general applicability and its simplicity in usage, the proposed process is usable as a standard method for image fusion scheme using phase contrast imaging, in particular on medical scanners (for instance mammography), inspection at industrial production lines, non-destructive testing, and homeland security.

摘要翻译： 图像融合方法将吸收，微分相位对比和X射线相位对比敏感技术获得的暗场（散射）信号，如光栅排列相结合。 该过程通过主成分分析来融合吸收和暗场信号。 此外，差分相位对比度被合并到PCA融合图像中以获得边缘增强效果。 由于其一般适用性和使用简单性，所提出的方法可用作使用相位成像的图像融合方案的标准方法，特别是在医疗扫描仪（例如乳腺X线照相术）上，在工业生产线上的检查，非破坏性测试 和国土安全。

公开(公告)号：US09036773B2

公开(公告)日：2015-05-19

申请号：US13807537

申请日：2011-04-04

申请人： Christian David ,  Marco Stampanoni

发明人： Christian David ,  Marco Stampanoni

IPC分类号： A61B6/00 ,  G01N23/04 ,  G21K1/02 ,  G21K1/06

CPC分类号： G01N23/04 ,  A61B6/4035 ,  A61B6/4291 ,  A61B6/484 ,  A61B6/502 ,  G21K1/025 ,  G21K1/06 ,  G21K2201/067 ,  G21K2207/005

摘要： An X-ray arrangement is suitable to record absorption, phase contrast, and dark field images of an object. The visibility of low absorbing specimens is improved and required radiation dose is reduced. The assembly includes an X-ray source; two or more gratings; a position-sensitive detector with spatially modulated detection sensitivity; a recorder for recording the images; an evaluator for evaluating the intensities for each pixel to identify the characteristic of the object for each individual pixel as an absorption and/or a differential phase contrast and/or an x-ray scattering dominated pixel. Images are collected by rotating from 0 to n or 2n either the sample or the assembly. The gratings are produced with planar geometry. The X-rays pass through the gratings parallel to the substrate. The grating structures extend along the X-ray path which determines the phase shift. The attenuation of the X-rays caused by the grating structures is no longer given by the thickness, but by the length of the grating structures.

摘要翻译： X射线装置适用于记录物体的吸收，相位对比度和暗场图像。 提高了低吸收标本的可见度，降低了所需的辐射剂量。 组件包括X射线源; 两个或更多个光栅; 具有空间调制检测灵敏度的位置敏感检测器; 用于记录图像的记录器; 评估器，用于评估每个像素的强度以识别作为吸收和/或差分相位对比度和/或x射线散射主导像素的每个单独像素的对象的特征。 通过从0到n或2n的样品或组件旋转收集图像。 光栅产生平面几何形状。 X射线穿过平行于衬底的光栅。 光栅结构沿着确定相移的X射线路径延伸。 由光栅结构引起的X射线的衰减不再由厚度给出，而是由光栅结构的长度给出。

公开(公告)号：US08972191B2

公开(公告)日：2015-03-03

申请号：US13148198

申请日：2010-02-03

申请人： Marco Stampanoni ,  Ziyu Wu ,  Peiping Zhu

发明人： Marco Stampanoni ,  Ziyu Wu ,  Peiping Zhu

IPC分类号： G01B9/02 ,  G01N21/31 ,  G06F3/00 ,  G06F3/01 ,  G01N23/04 ,  A61B6/00

CPC分类号： G01N23/04 ,  A61B6/00 ,  A61B6/4291 ,  A61B6/484

摘要： Phase sensitive X-ray imaging methods provide substantially increased contrast over conventional absorption based imaging, and therefore new and otherwise inaccessible information. The use of gratings as optical elements in hard X-ray phase imaging overcomes some of the problems impairing the wider use of phase contrast in X-ray radiography and tomography. To separate the phase information from other contributions detected with a grating interferometer, a phase-stepping approach has been considered, which implies the acquisition of multiple radiographic projections. Here, an innovative, highly sensitive X-ray tomographic phase contrast imaging approach is presented based on grating interferometry, which extracts the phase contrast signal without the need of phase stepping. Compared to the existing phase step approach, the main advantage of this new method dubbed “reverse projection” is the significantly reduced delivered dose, without degradation of the image quality.

摘要翻译： 相对于常规的基于吸收的成像，相敏X射线成像方法提供了显着增加的对比度，因此提供了新的和其他不可接近的信息。 在硬X射线相位成像中使用光栅作为光学元件克服了在X射线摄影和断层摄影中损害相对对比度的更广泛使用的一些问题。 为了将相位信息与用光栅干涉仪检测到的其他贡献分离，已经考虑了相位步进方法，这意味着获取多个射线照相投影。 在这里，基于光栅干涉测量提出了一种创新的，高灵敏度的X射线断层扫描相位成像方法，其提取相位差信号，而不需要相位步进。 与现有的相位步法相比，这种被称为“反向投影”的新方法的主要优点是显着降低了递送剂量，而不会降低图像质量。

公开(公告)号：US20140112440A1

公开(公告)日：2014-04-24

申请号：US13807537

申请日：2011-04-04

申请人： Christian David ,  Marco Stampanoni

发明人： Christian David ,  Marco Stampanoni

IPC分类号： G01N23/04

CPC分类号： G01N23/04 ,  A61B6/4035 ,  A61B6/4291 ,  A61B6/484 ,  A61B6/502 ,  G21K1/025 ,  G21K1/06 ,  G21K2201/067 ,  G21K2207/005

摘要： An X-ray arrangement is suitable to record absorption, phase contrast, and dark field images of an object. The visibility of low absorbing specimens is improved and required radiation dose is reduced. The assembly includes an X-ray source; two or more gratings; a position-sensitive detector with spatially modulated detection sensitivity; a recorder for recording the images; an evaluator for evaluating the intensities for each pixel to identify the characteristic of the object for each individual pixel as an absorption and/or a differential phase contrast and/or an x-ray scattering dominated pixel. Images are collected by rotating from 0 to n or 2n either the sample or the assembly. The gratings are produced with planar geometry. The X-rays pass through the gratings parallel to the substrate. The grating structures extend along the X-ray path which determines the phase shift. The attenuation of the X-rays caused by the grating structures is no longer given by the thickness, but by the length of the grating structures.

摘要翻译： X射线装置适用于记录物体的吸收，相位对比度和暗场图像。 提高了低吸收标本的可见度，降低了所需的辐射剂量。 组件包括X射线源; 两个或更多个光栅; 具有空间调制检测灵敏度的位置敏感检测器; 用于记录图像的记录器; 评估器，用于评估每个像素的强度以识别作为吸收和/或差分相位对比度和/或x射线散射主导像素的每个单独像素的对象的特征。 通过从0到n或2n的样品或组件旋转收集图像。 光栅产生平面几何形状。 X射线穿过平行于衬底的光栅。 光栅结构沿着确定相移的X射线路径延伸。 由光栅结构引起的X射线的衰减不再由厚度给出，而是由光栅结构的长度给出。