公开(公告)号：US07431685B2

公开(公告)日：2008-10-07

申请号：US10239986

申请日：2001-03-28

申请人： Andreas Frey ,  Juergen Helfman ,  Marcus Alexander Schmidt ,  Gerhard Mueller

发明人： Andreas Frey ,  Juergen Helfman ,  Marcus Alexander Schmidt ,  Gerhard Mueller

IPC分类号： C40B50/00

CPC分类号： C07K1/047 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00317 ,  B01J2219/00353 ,  B01J2219/00378 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00486 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00522 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07B2200/11 ,  C07K1/045 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

摘要： The aim of the invention is to investigate the bonding of substances to target molecules. This is achieved by means of a densely packed device wherein various target molecules are bonded in a large number of sample areas. Cross-contamination and evaporation need to be minimized. The active surface of the sample areas have to be maximized. The inventive solution resides in the use of carrier plates, containing densely packed capillary structures and having a very large inner surface despite small outer dimensions. 1000 times more molecules can be bonded than on a flat outer surface of a comparable size. Cross contamination is avoided by the lack of cross links between the capillaries. Evaporation is minimized by a small outer surface. After the inner surface of the capillaries has been silanized, peptides and peptidomimetics are synthesized in a locally targeted manner. The molecular interactions of components of the substance library with active substances in a solution or a suspension are investigated by means of a local resolution optical detection method. Handling, especially cleaning and covering with substances, is carried out in a simple manner by rinsing liquids through the capillary plate.

摘要翻译： 本发明的目的是研究物质与目标分子的结合。 这是通过密集包装的装置实现的，其中各种目标分子结合在大量的样品区域中。 交叉污染和蒸发需要最小化。 样品区域的活性表面必须最大化。 本发明的解决方案在于使用载体板，其包含密集填充的毛细结构，并且尽管具有小的外部尺寸，但具有非常大的内表面。 与可比尺寸的平坦外表面相比，可以结合1000倍的分子。 由于毛细管之间缺少交叉连接来避免交叉污染。 蒸发通过小的外表面最小化。 在毛细血管的内表面已被硅烷化之后，肽和肽模拟物以局部靶向的方式合成。 通过局部分辨光学检测方法研究物质文库的成分与溶液或悬浮液中活性物质的分子相互作用。 通过用毛细管冲洗液体，以简单的方式进行处理，特别是清洁和物质的覆盖。