公开(公告)号：US20090325176A1

公开(公告)日：2009-12-31

申请号：US12478940

申请日：2009-06-05

申请人： Margot Mary O'Toole ,  Frederick William Immermann ,  Padmalatha Sunkara Reddy ,  Andrew Arthur Hill ,  John Louis Ryan ,  Andrew Joseph Dorner ,  Cristina Ileana Csimma ,  Charlotte Marie McKee ,  Wei Liu ,  Divya Chaudhary ,  Matthew Ren Silver

发明人： Margot Mary O'Toole ,  Frederick William Immermann ,  Padmalatha Sunkara Reddy ,  Andrew Arthur Hill ,  John Louis Ryan ,  Andrew Joseph Dorner ,  Cristina Ileana Csimma ,  Charlotte Marie McKee ,  Wei Liu ,  Divya Chaudhary ,  Matthew Ren Silver

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C40B40/08 ,  C40B40/10

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5047 ,  G01N33/6845 ,  G01N2800/122 ,  G01N2800/52 ,  G01N2800/60

摘要： The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma.

摘要翻译： 本发明通过评估来自患者的样品中哮喘恶化基因产物的表达水平，提供了用于评估，诊断或预测哮喘恶化的方法。 本发明的标记物可用于鉴定或评估能够调节患有哮喘的受试者的标志物表达水平的试剂的方法。

公开(公告)号：US20090155784A1

公开(公告)日：2009-06-18

申请号：US12017178

申请日：2008-01-21

申请人： Margot Mary O'Toole ,  Frederick William Immermann ,  Andrew Joseph Dorner ,  Padmalatha Sunkara Reddy ,  Holly Marie Legault ,  Kerry Ann Whalen

发明人： Margot Mary O'Toole ,  Frederick William Immermann ,  Andrew Joseph Dorner ,  Padmalatha Sunkara Reddy ,  Holly Marie Legault ,  Kerry Ann Whalen

IPC分类号： C12Q1/68 ,  C40B40/08

CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2800/122

摘要： The present invention provides methods for the assessment, diagnosis, or prognosis of asthma including methods for providing an assessment, diagnosis, or prognosis comprising the step of exposing a sample derived from a patient to an allergen in vitro. The present invention also provides methods for selecting, as well as evaluating the effectiveness of, asthma treatments. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma

摘要翻译： 本发明提供了用于评估，诊断或预后哮喘的方法，包括用于提供评估，诊断或预后的方法，包括将来自患者的样品暴露于体外的变应原的步骤。 本发明还提供了用于选择和评估哮喘治疗的有效性的方法。 本发明的标记物可用于鉴定或评估能够调节患有哮喘的受试者的标志物表达水平的试剂的方法

公开(公告)号：US20080226645A1

公开(公告)日：2008-09-18

申请号：US12008691

申请日：2008-01-10

申请人： Margot Mary O'Toole ,  Frederick William Immermann ,  Andrew Arthur Hill ,  Padmalatha Sunkara Reddy ,  Michael Edward Burczynski ,  Douglas Kenneth Miller ,  Karl Henry Nocka ,  Stanley Francis Wolf ,  Michael Ronald Bowman ,  Andrew Joseph Dorner ,  I-Ming Wang

发明人： Margot Mary O'Toole ,  Frederick William Immermann ,  Andrew Arthur Hill ,  Padmalatha Sunkara Reddy ,  Michael Edward Burczynski ,  Douglas Kenneth Miller ,  Karl Henry Nocka ,  Stanley Francis Wolf ,  Michael Ronald Bowman ,  Andrew Joseph Dorner ,  I-Ming Wang

IPC分类号： A61K31/7088 ,  C40B40/06 ,  A61K39/395 ,  C07K16/00 ,  A61K31/7105 ,  C07H21/00 ,  A61K38/02 ,  C40B30/00

CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition.

摘要翻译： 本发明提供了用于评估和治疗哮喘和其它炎性疾病的方法和组合物，特别是由白细胞介素-13（IL-13）介导的那些。 本发明还提供了包含哮喘标志物以及IL-13反应性的阵列。 本发明的标记可以用于诊断患有哮喘或IL-13介导的病症的患者的方法，以评估潜在治疗剂的有效性，鉴定或评估能够调节标记物表达水平的药剂，以及 选择治疗患有哮喘或IL-13介导病症的患者。