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公开(公告)号：US08663653B2
公开(公告)日：2014-03-04
申请号：US13059130
申请日：2009-07-24
CPC分类号： C12N7/00 , A61K2039/53 , C07K14/005 , C07K16/109 , C07K2317/76 , C12N2770/24221 , C12N2770/24222
摘要： The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
摘要翻译： 本发明人开发了丙型肝炎病毒2b / 2a基因型重组体，其中JFH1结构基因（Core，E1和E2），p7和完整的NS2被基因型2b参照菌株J8的相应基因替代。 来自2个转染实验的回收的2b / 2a重组体的序列分析显示2b / 2a在遗传上是稳定的。 结论：开发的2b / 2a病毒为HCV基因型2b的研究提供了强大的体外工具，包括疫苗研究和功能分析。
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2.发明申请公开(公告)号：US20110294194A1
公开(公告)日：2011-12-01
申请号：US13059130
申请日：2009-07-24
CPC分类号： C12N7/00 , A61K2039/53 , C07K14/005 , C07K16/109 , C07K2317/76 , C12N2770/24221 , C12N2770/24222
摘要： The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analyses.
摘要翻译： 本发明人开发了丙型肝炎病毒2b / 2a基因型重组体，其中JFH1结构基因（Core，E1和E2），p7和完整的NS2被基因型2b参照菌株J8的相应基因替代。 来自2个转染实验的回收的2b / 2a重组体的序列分析显示2b / 2a在遗传上是稳定的。 结论：开发的2b / 2a病毒为HCV基因型2b的研究提供了强大的体外工具，包括疫苗研究和功能分析。
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