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1.发明授权High fidelity detection of nucleic acid differences by ligase detection reaction 失效通过连接酶检测反应高度保真检测核酸差异公开(公告)号：US06312892B1
公开(公告)日：2001-11-06
申请号：US08891292
申请日：1997-07-10
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
摘要翻译： 利用连接酶检测反应在常规模板过量存在下用热稳定连接酶区分少数模板。 该过程可以用突变连接酶，热稳定连接酶或修饰的寡核苷酸探针进行。 该过程对癌症相关突变的检测特别有用。 它具有提供少量模板数量或比例的定量测量的优点。
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2.发明授权High fidelity detection of nucleic acid differences by ligase detection reaction 有权通过连接酶检测反应高度保真检测核酸差异公开(公告)号：US07244831B2
公开(公告)日：2007-07-17
申请号：US10405882
申请日：2003-04-01
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
摘要翻译： 利用连接酶检测反应在常规模板过量存在下用热稳定连接酶区分少数模板。 该过程可以用突变连接酶，热稳定连接酶或修饰的寡核苷酸探针进行。 该过程对癌症相关突变的检测特别有用。 它具有提供少量模板数量或比例的定量测量的优点。
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3.发明申请High fidelity detection of nucleic acid differences by ligase detection reaction 有权通过连接酶检测反应高度保真检测核酸差异公开(公告)号：US20050037346A1
公开(公告)日：2005-02-17
申请号：US10405882
申请日：2003-04-01
申请人： Francis Barany , Jianying Luo , Marilyn Khanna , Donald Bergstrom
发明人： Francis Barany , Jianying Luo , Marilyn Khanna , Donald Bergstrom
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
摘要翻译： 利用连接酶检测反应在常规模板过量存在下用热稳定连接酶区分少数模板。 该过程可以用突变连接酶，热稳定连接酶或修饰的寡核苷酸探针进行。 该过程对癌症相关突变的检测特别有用。 它具有提供少量模板数量或比例的定量测量的优点。
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公开(公告)号：US06576453B2
公开(公告)日：2003-06-10
申请号：US09927737
申请日：2001-08-10
IPC分类号： C12N910
CPC分类号： C12Q1/6827 , C07K14/82 , C12N9/93 , C12Q1/6837 , C12Q1/6862 , C12Q2531/113 , C12Q2561/125 , C12Q2565/501
摘要： Ligase detection reaction is utilized to distinguish minority template in the presence of an excess of normal template with a thermostable ligase. This process can be carried out with a mutant ligase, thermostable ligase, or a modified oligonucleotide probe. This procedure is particularly useful for the detection of cancer-associated mutations. It has the advantage of providing a quantitative measure of the amount or ratio of minority template.
摘要翻译： 利用连接酶检测反应在常规模板过量存在下用热稳定连接酶区分少数模板。 该过程可以用突变连接酶，热稳定连接酶或修饰的寡核苷酸探针进行。 该过程对癌症相关突变的检测特别有用。 它具有提供少量模板数量或比例的定量测量的优点。
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