-
公开(公告)号：US20120101255A1
公开(公告)日：2012-04-26
申请号：US13279703
申请日：2011-10-24
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04
摘要： The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.
摘要翻译： 本发明涉及蛋白质和多肽以及使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物，并测量Cx43CT- 结合Cx43CT的化合物的结合亲和力。
-
2.发明申请公开(公告)号：US20120264693A1
公开(公告)日：2012-10-18
申请号：US13377773
申请日：2010-06-11
IPC分类号： A61K38/12 , C12N5/07 , A61P9/00 , A61P17/00 , A61P27/02 , A61P13/10 , A61P19/10 , A61P13/12 , A61P35/00 , A61P19/00 , A61P13/02 , C07K7/64 , A61P25/00
CPC分类号： G01N33/5032 , A61K38/00 , C07K7/64
摘要： Compounds capable of modulating intracellular gap junctional communication, as well as their use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC) 1 are disclosed.
摘要翻译： 公开了能够调节细胞间隙连接通讯的化合物及其在治疗与间隙连接细胞内通讯（GJIC）1相关的疾病中的用途。
-
公开(公告)号：US20100298225A1
公开(公告)日：2010-11-25
申请号：US12669351
申请日：2008-07-14
IPC分类号： A61K38/16 , C07K14/00 , C07K7/06 , A61P9/00 , C07K7/08 , A61P29/00 , A61K38/10 , A61K38/08 , A61P27/16 , A61P13/10 , A61P13/12 , A61P25/00 , A61P37/06 , A61P35/00 , A61P11/00
CPC分类号： C07K14/705 , A61K38/00 , C07K5/0817 , C07K5/1019
摘要： Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).
摘要翻译： 公开了促进由间隙连接介导的细胞间通讯的肽。 本发明具有广泛的有用应用，包括用于治疗与间隙连接细胞内通讯（GJIC）相关的疾病。
-
公开(公告)号：US20090075291A1
公开(公告)日：2009-03-19
申请号：US12172355
申请日：2008-07-14
IPC分类号： G01N33/53 , C07K14/00 , G01N33/566
CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04
摘要： The present invention relates to proteins and polypeptides that (i) have the formula A-[Wm-A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A-An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.
摘要翻译： 本发明涉及（i）具有式A- [Wm-A] n的蛋白质和多肽，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸 ; 每个W独立地是一个连接体; m为1或2; n是从1到5的任何数字; （ii）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从零到十五的任何数，m是从零到十五的任何数，以及n和 m是从8到15的任何数字; （iii）具有式A-An，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸; n是从1到5的任何数字; 或（iv）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从0到7的任何数字，m是从0到7的任何数字，并且n的总和 m是从零到七的任何数字。 使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物和测量与Cx43CT结合的化合物的Cx43CT结合亲和力，也是 披露
-
-
-
搜索结果
4 条记录 (耗时 0.014 秒)
