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    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    1.
    发明申请
    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
    基于肽基的GAP结构调节

    公开(公告)号：US20090075291A1

    公开(公告)日：2009-03-19

    申请号：US12172355

    申请日：2008-07-14

    申请人： Mario DELMAR ,  Steven M. TAFFET ,  Bjarne Due LARSEN

    发明人： Mario DELMAR ,  Steven M. TAFFET ,  Bjarne Due LARSEN

    IPC分类号： G01N33/53 ,  C07K14/00 ,  G01N33/566

    CPC分类号： G01N33/6872 ,  C07K14/705 ,  G01N2500/04

    摘要： The present invention relates to proteins and polypeptides that (i) have the formula A-[Wm-A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2; and n is any number from 1 through 5; (ii) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to fifteen, m is any number from zero to fifteen, and the sum of n and m is any number from eight to fifteen; (iii) have the formula A-An where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; and n is any number from 1 through 5; or (iv) consist essentially of the formula XnRXPXm where each X is independently any amino acid, R is arginine, P is proline, n is any number from zero to seven, m is any number from zero to seven, and the sum of n and m is any number from zero to seven. Methods using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT, are also disclosed.

    摘要翻译： 本发明涉及（i）具有式A- [Wm-A] n的蛋白质和多肽，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸 ; 每个W独立地是一个连接体; m为1或2; n是从1到5的任何数字; （ii）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从零到十五的任何数，m是从零到十五的任何数，以及n和 m是从8到15的任何数字; （iii）具有式A-An，其中每个A独立地是式XXXXRXPXXXX的肽，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸; n是从1到5的任何数字; 或（iv）基本上由式XnRXPXm组成，其中每个X独立地是任何氨基酸，R是精氨酸，P是脯氨酸，n是从0到7的任何数字，m是从0到7的任何数字，并且n的总和 m是从零到七的任何数字。 使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物和测量与Cx43CT结合的化合物的Cx43CT结合亲和力，也是 披露

    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS
    2.
    发明申请
    PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
    基于肽基的GAP结构调节

    公开(公告)号：US20120101255A1

    公开(公告)日：2012-04-26

    申请号：US13279703

    申请日：2011-10-24

    申请人： Mario Delmar ,  Steven M. Taffet ,  Bjarne Due Larsen

    发明人： Mario Delmar ,  Steven M. Taffet ,  Bjarne Due Larsen

    IPC分类号： C07K14/00 ,  C07K2/00

    CPC分类号： G01N33/6872 ,  C07K14/705 ,  G01N2500/04

    摘要： The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.

    摘要翻译： 本发明涉及蛋白质和多肽以及使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物，并测量Cx43CT- 结合Cx43CT的化合物的结合亲和力。