专利检索 ap:("Mario Delmar" OR "Steven M. Taffet" OR "Wanda Coombs" OR "Vandana Verma" OR "Bjarne Due Larsen") AND inv:"Steven M. Taffet" 第 1 页

1.

发明申请
COMPOUNDS ACTING AS PEPTIDE GAP JUNCTION MODULATORS, AND USES THEREOF 审中-公开
标题翻译：作为肽桥接调制器的化合物及其用途

公开(公告)号：US20120264693A1

公开(公告)日：2012-10-18

申请号：US13377773

申请日：2010-06-11

申请人： Mario Delmar , Steven M. Taffet , Wanda Coombs , Vandana Verma , Bjarne Due Larsen

发明人： Mario Delmar , Steven M. Taffet , Wanda Coombs , Vandana Verma , Bjarne Due Larsen

IPC分类号： A61K38/12 , C12N5/07 , A61P9/00 , A61P17/00 , A61P27/02 , A61P13/10 , A61P19/10 , A61P13/12 , A61P35/00 , A61P19/00 , A61P13/02 , C07K7/64 , A61P25/00

CPC分类号： G01N33/5032 , A61K38/00 , C07K7/64

摘要： Compounds capable of modulating intracellular gap junctional communication, as well as their use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC) 1 are disclosed.

摘要翻译： 公开了能够调节细胞间隙连接通讯的化合物及其在治疗与间隙连接细胞内通讯（GJIC）1相关的疾病中的用途。

2.

发明申请
PEPTIDE GAP JUNCTION MODULATORS 审中-公开
标题翻译：肽阻塞调节器

公开(公告)号：US20100298225A1

公开(公告)日：2010-11-25

申请号：US12669351

申请日：2008-07-14

申请人： Bjarne Due Larsen , Mario Delmar , Steven M. Taffet , Wanda Coombs

发明人： Bjarne Due Larsen , Mario Delmar , Steven M. Taffet , Wanda Coombs

IPC分类号： A61K38/16 , C07K14/00 , C07K7/06 , A61P9/00 , C07K7/08 , A61P29/00 , A61K38/10 , A61K38/08 , A61P27/16 , A61P13/10 , A61P13/12 , A61P25/00 , A61P37/06 , A61P35/00 , A61P11/00

CPC分类号： C07K14/705 , A61K38/00 , C07K5/0817 , C07K5/1019

摘要： Disclosed are peptides that facilitate the intercellular communication mediated by gap junctions. The invention has a wide spectrum of useful applications including use in the treatment of diseases associated with impaired gap junction intracellular communication (GJIC).

摘要翻译： 公开了促进由间隙连接介导的细胞间通讯的肽。本发明具有广泛的有用应用，包括用于治疗与间隙连接细胞内通讯（GJIC）相关的疾病。

3.

发明申请
PEPTIDE-BASED REGULATION OF GAP JUNCTIONS 审中-公开
标题翻译：基于肽基的GAP结构调节

公开(公告)号：US20120101255A1

公开(公告)日：2012-04-26

申请号：US13279703

申请日：2011-10-24

申请人： Mario Delmar , Steven M. Taffet , Bjarne Due Larsen

发明人： Mario Delmar , Steven M. Taffet , Bjarne Due Larsen

IPC分类号： C07K14/00 , C07K2/00

CPC分类号： G01N33/6872 , C07K14/705 , G01N2500/04

摘要： The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.

摘要翻译： 本发明涉及蛋白质和多肽以及使用这些蛋白质和多肽的方法：鉴定Cx43CT的RXP结合结构域的位置，调节Cx43间隙连接通道，筛选调节Cx43CT的化合物，并测量Cx43CT- 结合Cx43CT的化合物的结合亲和力。