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公开(公告)号：US06592821B1
公开(公告)日：2003-07-15
申请号：US09853887
申请日：2001-05-10
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow , Yevgeny Yurkovetsky , Javier Anibal Farinas
IPC分类号： G01N3348
CPC分类号： B01F13/0062 , B01J19/0093 , B01L3/502776 , B01L2200/0636 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/11
摘要： Methods and systems for particle focusing to increase assay throughput and sensitivity in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译： 提供了粒子聚焦的方法和系统，以增加微量体系中的分析产量和灵敏度。 本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。 还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。 另外包括其中聚焦和/或分选颗粒的集成系统。
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2.发明授权Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection 有权使用压力注射，芯吸和电动注射在微量通道中连续液体流动的方法和装置公开(公告)号：US06416642B1
公开(公告)日：2002-07-09
申请号：US09245627
申请日：1999-02-05
IPC分类号： G01N2726
CPC分类号： B01L3/50273 , B01J19/0093 , B01J2219/00891 , B01L3/502746 , B01L2300/069 , B01L2300/0816 , B01L2300/0861 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N27/44743 , G01N27/44791
摘要： Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of materials through a side channel and the use of an absorbent material to induce wicking in the channel system. The apparatus provided includes a prefabricated wick in the device to provide for flow rate control. Additional methods for determining velocity of a particle and cell incubation time are also provided.
摘要翻译： 提供了用于调节微流体装置中的流速的装置和方法。 该方法涉及调节装置中的下游压力以改变装置的上游区域中的材料的流速。 这种方法包括通过侧通道的电动注射或材料抽出，以及使用吸收材料在通道系统中诱导芯吸。 提供的装置包括在装置中的预制芯以提供流量控制。 还提供了用于确定颗粒速度和细胞孵育时间的其它方法。
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3.发明授权公开(公告)号：US06989128B2
公开(公告)日：2006-01-24
申请号：US10142263
申请日：2002-05-08
IPC分类号： B01L3/02 , G01N27/453
CPC分类号： B01L3/50273 , B01J19/0093 , B01J2219/00891 , B01L3/502746 , B01L2300/069 , B01L2300/0816 , B01L2300/0861 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N27/44743 , G01N27/44791
摘要： Apparatus and methods for modulating flow rates in microfluidic devices are provided. The methods involve modulating downstream pressure in the device to change the flow rate of materials in an upstream region of the device. Such methods include electrokinetic injection or withdrawal of materials through a side channel and the use of an absorbent material to induce wicking in the channel system. The apparatus provided includes a prefabricated wick in the device to provide for flow rate control. Additional methods for determining velocity of a particle and cell incubation time are also provided.
摘要翻译： 提供了用于调节微流体装置中的流速的装置和方法。 该方法涉及调节装置中的下游压力以改变装置的上游区域中的材料的流速。 这种方法包括通过侧通道的电动注射或材料抽出，以及使用吸收材料在通道系统中诱导芯吸。 提供的装置包括在装置中的预制芯以提供流量控制。 还提供了用于确定颗粒速度和细胞孵育时间的其它方法。
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公开(公告)号：US06506609B1
公开(公告)日：2003-01-14
申请号：US09569747
申请日：2000-05-11
申请人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
发明人： H. Garrett Wada , Anne R. Kopf-Sill , Marja Liisa Alajoki , J. Wallace Parce , Benjamin N. Wang , Andrea W. Chow , Robert S. Dubrow
IPC分类号： G01N700
CPC分类号： B01F13/0062 , B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0652 , B01L2400/0406 , B01L2400/0487 , G01N15/1404 , G01N27/44704 , G01N27/44791 , G01N2015/1409 , G01N2015/149 , G01N2333/4718 , Y10T436/117497 , Y10T436/2575
摘要： Methods and systems for particle focusing to increase assay throughput in microscale systems are provided. The invention includes methods for providing substantially uniform flow velocity to flowing particles in microfluidic devices. Methods of sorting members of particle populations, such as cells and various subcellular components are also provided. Integrated systems in which particles are focused and/or sorted are additionally included.
摘要翻译： 提供了用于增加微尺度系统中测定通过量的粒子聚焦的方法和系统。 本发明包括为微流体装置中的流动颗粒提供基本均匀的流速的方法。 还提供了分选颗粒群体成员的方法，例如细胞和各种亚细胞组分。 另外包括其中聚焦和/或分选颗粒的集成系统。
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