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1.发明申请POLYMERIC IMMUNOGLOBULIN FUSION PROTEINS THAT TARGET LOW AFFINITY FCyRECEPTORS 有权聚合物免疫球蛋白融合蛋白，目标低亲合力公开(公告)号：US20090117133A1
公开(公告)日：2009-05-07
申请号：US12212776
申请日：2008-09-18
CPC分类号： C07K16/283 , A61K2039/505 , C07K14/70517 , C07K14/765 , C07K16/00 , C07K16/2815 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/732 , C07K2317/74 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with FcγR and which allow for the inclusion and targeting of a second protein domain to cells expressing FcγR. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fission proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of FcγR in autoimmune disorders.
摘要翻译： 本发明涉及一系列核酸，多肽和克隆载体，其指导融合蛋白的表达，所述融合蛋白可以模拟聚集的IgG（AIG）和免疫复合物功能，与FcgammaR的相互作用有关，并允许包含和靶向第二 蛋白质结构域表达FcgammaR的细胞。 这通过表达与人IgG1的框架区域融合的人IgG1的铰链和CH2结构域（HCH2）的多个线性拷贝来实现。 方便的限制性位点允许容易地引入另外的氨基末端结构域。 还公开了使用裂变蛋白治疗患者的方法。 这里描述的HCH2聚合物代表了设计用于自身免疫疾病中FcgammaR的治疗靶向的重组蛋白质的新策略。
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2.发明授权Data path synthesis apparatus and method for optimizing a behavioral design description being processed by a behavioral synthesis tool 有权用于优化由行为综合工具处理的行为设计描述的数据路径合成装置和方法公开(公告)号：US07305650B1
公开(公告)日：2007-12-04
申请号：US11157181
申请日：2005-06-20
申请人： Mark A. Jensen
发明人： Mark A. Jensen
IPC分类号： G06F17/50
CPC分类号： G06F17/505 , G06F2217/08
摘要： A data path optimization element is used in a behavioral synthesis process to optimize portions of an algorithmic description of a digital logic circuit. Directives are provided in the algorithmic description to identify subsets of the algorithmic description that can be extracted and optimized. The optimization includes identification of certain operators, function calls, conditional statements, or other relationships in the subset, and then compression of the extracted subset into or more data path components in a building block. The building block thus generated is substituted back into the algorithmic description and used in subsequent operations during the behavioral synthesis process, thereby leading to a more optimum design in terms of area, performance, power characteristics, or other characteristic(s).
摘要翻译： 在行为合成过程中使用数据路径优化元件来优化数字逻辑电路的算法描述的部分。 在算法描述中提供指令以识别可以提取和优化的算法描述的子集。 优化包括识别某些运算符，函数调用，条件语句或子集中的其他关系，然后将提取的子集压缩到构建块中的多个数据路径组件中。 由此生成的构建块被替换为算法描述，并且在行为合成过程期间用于后续操作，从而在面积，性能，功率特性或其他特性方面导致更优化的设计。
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3.发明授权Method to amplify nucleic acids to generate fluorescence labeled fragments of conserved and arbitrary products 有权扩增核酸以产生保守和任意产物的荧光标记片段的方法公开(公告)号：US09040242B2
公开(公告)日：2015-05-26
申请号：US13553256
申请日：2012-07-19
申请人： Anjana Agarwal , Mark A. Jensen
发明人： Anjana Agarwal , Mark A. Jensen
CPC分类号： C12Q1/689 , C12Q1/6846 , C12Q1/686 , C12Q2527/101 , C12Q2535/139
摘要： Disclosed herein are methods for the identification of the species, serotype, and strain of a microorganism. Also disclosed are primers for use in detecting such microorganisms and kits comprising such primers.
摘要翻译： 本文公开了用于鉴定微生物的物种，血清型和菌株的方法。 还公开了用于检测这些微生物的引物和包含这种引物的试剂盒。
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4.发明申请公开(公告)号：US20130078634A1
公开(公告)日：2013-03-28
申请号：US13630045
申请日：2012-09-28
CPC分类号： C12Q1/689
摘要： This invention relates to a rapid method for detection and characterization of STEC bacteria based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect STEC bacteria in a food or water sample, such as a beef enrichment. The present invention further relates to isolated polynucleotides, replication compositions, kits, and reagent tablets for carrying out the method of the present invention.
摘要翻译： 本发明涉及基于核酸序列的存在，特别是基于PCR的检测方法以及因此有用的寡核苷酸分子和试剂和试剂盒来检测和表征STEC细菌的快速方法。 该方法优选用于检测食品或水样品中的STEC细菌，例如牛肉富集。 本发明还涉及用于实施本发明的方法的分离的多核苷酸，复制组合物，试剂盒和试剂片。
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5.发明申请POLYMERIC IMMUNOGLOBULIN FUSION PROTEINS THAT TARGET LOW AFFINITY FCy RECEPTORS 有权聚合物免疫球蛋白融合蛋白，目标低亲和力受体公开(公告)号：US20110195067A1
公开(公告)日：2011-08-11
申请号：US13026207
申请日：2011-02-12
IPC分类号： A61K39/395 , C07H21/00 , C12N5/071 , C12N15/63 , A61P37/02
CPC分类号： C07K16/283 , A61K2039/505 , C07K14/70517 , C07K14/765 , C07K16/00 , C07K16/2815 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/732 , C07K2317/74 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with FcγR and which allow for the inclusion and targeting of a second protein domain to cells expressing FcγR. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of FcγR in autoimmune disorders.
摘要翻译： 本发明涉及一系列核酸，多肽和克隆载体，其指导融合蛋白的表达，所述融合蛋白可以相对于其与FcγR的相互作用而模拟聚集的IgG（AIG）和免疫复合物功能，并且允许包含和靶向第二 蛋白质结构域到表达FcγR的细胞。 这通过表达与人IgG1的框架区域融合的人IgG1的铰链和CH2结构域（HCH2）的多个线性拷贝来实现。 方便的限制性位点允许容易地引入另外的氨基末端结构域。 还公开了使用融合蛋白治疗患者的方法。 这里描述的HCH2聚合物是设计用于自身免疫疾病中FcγR的治疗靶向的重组蛋白质的新策略。
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6.发明授权
公开(公告)号：US5340728A
公开(公告)日：1994-08-23
申请号：US990297
申请日：1992-12-09
申请人： Ron Grosz , Mark A. Jensen
发明人： Ron Grosz , Mark A. Jensen
CPC分类号： C12Q1/6858 , C12Q1/686
摘要： An improved method for performing a nested polymerase chain reaction (PCR) amplification of a targeted piece of DNA, wherein by controlling the annealing times and concentration of both the outer and the inner set of primers according to the method disclosed, highly specific and efficient amplification of a targeted piece of DNA can be achieved within one reaction vessel without depletion or removal of the outer primers from the reaction mixture vessel.
摘要翻译： 一种用于进行靶DNA片段的巢式聚合酶链式反应（PCR）扩增的改进方法，其中通过根据所公开的方法控制外引导组和内引物组的退火时间和浓度，其具有高度特异性和有效的扩增 可以在一个反应容器内实现目标DNA片段，而不会从反应混合物容器中消耗或除去外部引物。
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7.发明授权公开(公告)号：US08802371B2
公开(公告)日：2014-08-12
申请号：US13630045
申请日：2012-09-28
CPC分类号： C12Q1/689
摘要： This invention relates to a rapid method for detection and characterization of STEC bacteria based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect STEC bacteria in a food or water sample, such as a beef enrichment. The present invention further relates to isolated polynucleotides, replication compositions, kits, and reagent tablets for carrying out the method of the present invention.
摘要翻译： 本发明涉及基于核酸序列的存在，特别是基于PCR的检测方法以及因此有用的寡核苷酸分子和试剂和试剂盒来检测和表征STEC细菌的快速方法。 该方法优选用于检测食品或水样品中的STEC细菌，例如牛肉富集。 本发明还涉及用于实施本发明的方法的分离的多核苷酸，复制组合物，试剂盒和试剂片。
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8.发明申请公开(公告)号：US20130029341A1
公开(公告)日：2013-01-31
申请号：US13553256
申请日：2012-07-19
申请人： Anjana AGARWAL , Mark A. Jensen
发明人： Anjana AGARWAL , Mark A. Jensen
IPC分类号： G01N21/64
CPC分类号： C12Q1/689 , C12Q1/6846 , C12Q1/686 , C12Q2527/101 , C12Q2535/139
摘要： Disclosed herein are methods for the identification of the species, serotype, and strain of a microorganism. Also disclosed are primers for use in detecting such microorganisms and kits comprising such primers.
摘要翻译： 本文公开了用于鉴定微生物的物种，血清型和菌株的方法。 还公开了用于检测这些微生物的引物和包含这种引物的试剂盒。
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9.发明授权Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors 有权靶向低亲和力Fcγ受体的聚合免疫球蛋白融合蛋白公开(公告)号：US07511121B2
公开(公告)日：2009-03-31
申请号：US10096521
申请日：2002-03-11
IPC分类号： C07K16/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K14/70517 , C07K14/765 , C07K16/00 , C07K16/2815 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/732 , C07K2317/74 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with FcγR and which allow for the inclusion and targeting of a second protein domain to cells expressing FcγR. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of FcγR in autoimmune disorders.
摘要翻译： 本发明涉及一系列核酸，多肽和克隆载体，其指导融合蛋白的表达，所述融合蛋白可以模拟聚集的IgG（AIG）和免疫复合物功能，与FcgammaR的相互作用有关，并允许包含和靶向第二 蛋白质结构域表达FcgammaR的细胞。 这通过表达与人IgG1的框架区域融合的人IgG1的铰链和CH2结构域（HCH2）的多个线性拷贝来实现。 方便的限制性位点允许容易地引入另外的氨基末端结构域。 还公开了使用融合蛋白治疗患者的方法。 这里描述的HCH2聚合物代表了设计用于自身免疫疾病中FcgammaR的治疗靶向的重组蛋白质的新策略。
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公开(公告)号：US08986698B2
公开(公告)日：2015-03-24
申请号：US13026207
申请日：2011-02-12
IPC分类号： A61K39/00 , A61K39/38 , A61K39/395 , C07K16/28 , C07K16/00 , C07K14/765
CPC分类号： C07K16/283 , A61K2039/505 , C07K14/70517 , C07K14/765 , C07K16/00 , C07K16/2815 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/64 , C07K2317/732 , C07K2317/74 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30
摘要： The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated IgG (AIG) and immune complex function with respect to their interactions with FcγR and which allow for the inclusion and targeting of a second protein domain to cells expressing FcγR. This was accomplished by expressing multiple linear copies of the hinge and CH2 domains (HCH2) of human IgG1 fused to the framework region of human IgG1. Convenient restriction sites allow for the facile introduction of additional amino-terminal domains. Methods for treating patients using fusion proteins are also disclosed. The HCH2 polymers described here represent a new strategy in the design of recombinant proteins for the therapeutic targeting of FcγR in autoimmune disorders.
摘要翻译： 本发明涉及一系列核酸，多肽和克隆载体，其指导融合蛋白的表达，所述融合蛋白可以相对于其与FcγR的相互作用而模拟聚集的IgG（AIG）和免疫复合物功能，并且允许包含和靶向第二 蛋白质结构域到表达FcγR的细胞。 这通过表达与人IgG1的框架区域融合的人IgG1的铰链和CH2结构域（HCH2）的多个线性拷贝来实现。 方便的限制性位点允许容易地引入另外的氨基末端结构域。 还公开了使用融合蛋白治疗患者的方法。 这里描述的HCH2聚合物是设计用于自身免疫疾病中FcγR的治疗靶向的重组蛋白质的新策略。
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