公开(公告)号：US20130281419A1

公开(公告)日：2013-10-24

申请号：US13673500

申请日：2012-11-09

申请人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

发明人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

IPC分类号： A61K31/575

CPC分类号： A61K31/575 ,  C07J41/0055

摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

摘要翻译： 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1，或其药学上可接受的盐，和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中，通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如，可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲，并且可以产生利尿作用。

公开(公告)号：US07410959B1

公开(公告)日：2008-08-12

申请号：US09885247

申请日：2000-07-13

申请人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

发明人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

IPC分类号： A61K31/56 ,  A61K31/555 ,  A01N55/02 ,  C07J41/00

CPC分类号： A61K31/575 ,  C07J41/0055

摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

摘要翻译： 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1，或其药学上可接受的盐，和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中，通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如，可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲，并且可以产生利尿作用。

公开(公告)号：US20080221075A1

公开(公告)日：2008-09-11

申请号：US12041440

申请日：2008-03-03

申请人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

发明人： Michael Zasloff ,  Jon Williams ,  William Kinney ,  Mark Anderson ,  Michael McLane

IPC分类号： A61K31/56 ,  C07J41/00 ,  A61P3/04

CPC分类号： A61K31/575 ,  C07J41/0055

摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

摘要翻译： 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1，或其药学上可接受的盐，和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中，通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如，可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲，并且可以产生利尿作用。

公开(公告)号：US5795885A

公开(公告)日：1998-08-18

申请号：US483057

申请日：1995-06-07

申请人： Michael Zasloff ,  Ann Shinnar ,  William Kinney ,  Mark Anderson ,  Jon Williams ,  Michael McLane

发明人： Michael Zasloff ,  Ann Shinnar ,  William Kinney ,  Mark Anderson ,  Jon Williams ,  Michael McLane

IPC分类号： C07J41/00 ,  G01N33/50 ,  A61K31/56

CPC分类号： G01N33/5011 ,  C07J41/0005 ,  G01N33/5008 ,  G01N33/5044 ,  G01N33/5047 ,  G01N33/5061 ,  G01N33/5064 ,  G01N33/5088 ,  G01N2500/00

摘要： Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

摘要翻译： 描述了可用作钠/质子交换器（NHE）的抑制剂的氨基甾醇化合物。 还公开了使用这种氨基甾醇化合物的方法，包括那些使用作为NHE光谱的抑制剂的化合物以及仅使用一种特异性NHE抑制剂的化合物的方法。 还公开了有利的筛选技术和用于评价化合物治疗活性的测定法。

公开(公告)号：US20090105204A1

公开(公告)日：2009-04-23

申请号：US12254656

申请日：2008-10-20

申请人： Michael Zasloff ,  Jon Wiliams ,  William Kinney ,  Mark Anderson ,  Michael McLane

发明人： Michael Zasloff ,  Jon Wiliams ,  William Kinney ,  Mark Anderson ,  Michael McLane

IPC分类号： A61K31/575 ,  A61P9/10 ,  A61P3/10 ,  A61P3/04

CPC分类号： C07J41/0005 ,  A61K31/575

摘要： A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

摘要翻译： 药物组合物包含作为活性成分的如图14所示的根据式1436的化合物。 1，或其药学上可接受的盐，和药学上可接受的载体或赋形剂。 可以生产包括该药物组合物的各种药物。 这样的药物可以用于治疗肥胖或糖尿病。 还描述了使用药物组合物的方法。 在这些方法中，通过施用有效量的药物组合物来治疗各种疾病或其他身体功能被激活或抑制。 例如，可以通过施用有效量的药物组合物来治疗糖尿病和肥胖症。 通过施用有效量的这些药物组合物可以抑制体重增加和生长因子产生。 可以通过施用有效量的药物组合物来抑制食欲，并且可以产生利尿作用。

公开(公告)号：US06399370B1

公开(公告)日：2002-06-04

申请号：US09228302

申请日：1999-01-12

申请人： James M. Wilson ,  Mitchell Goldman ,  Robert Bals ,  Ethan D. Stolzenberg ,  Mark Anderson ,  Michael Zasloff ,  Prasad Kari

发明人： James M. Wilson ,  Mitchell Goldman ,  Robert Bals ,  Ethan D. Stolzenberg ,  Mark Anderson ,  Michael Zasloff ,  Prasad Kari

IPC分类号： C07H2100

CPC分类号： C07K14/4723 ,  A61K38/00

摘要： The invention relates to mammalian beta defensin and methods of use thereof for treatment of microbial infection.

摘要翻译： 本发明涉及哺乳动物β防御素及其用于治疗微生物感染的方法。

公开(公告)号：US08807133B2

公开(公告)日：2014-08-19

申请号：US13009722

申请日：2011-01-19

申请人： Mark Anderson

发明人： Mark Anderson

IPC分类号： A61D7/04 ,  A61D1/08 ,  A61M16/06 ,  A61M16/00

CPC分类号： A61D7/04 ,  A61D1/08 ,  A61M1/0066 ,  A61M16/0057 ,  A61M16/0072 ,  A61M16/0084 ,  A61M16/06 ,  A61M2205/073 ,  A61M2250/00

摘要： An aspiration and resuscitation system which is useable to perform aspiration and/or resuscitation procedures on living beings, particularly small animals, and most particularly newborn small animals such as puppies and kittens. The system includes an aspirator and a resuscitator. Each includes a separable pump and animal interface mask. Further disclosed are aspiration and resuscitation methods using the disclosed apparatus.

摘要翻译： 一种吸气和复苏系统，可用于对生物，特别是小型动物，特别是新生小动物（如小狗和小猫）进行抽吸和/或复苏程序。 该系统包括吸气器和复苏器。 每个都包括一个可分离的泵和动物界面面罩。 进一步公开了使用所公开的装置的抽吸和复苏方法。

公开(公告)号：US08751514B2

公开(公告)日：2014-06-10

申请号：US13219415

申请日：2011-08-26

申请人： Harold Kester ,  Dan Ruskin ,  Chris Lee ,  Mark Anderson

发明人： Harold Kester ,  Dan Ruskin ,  Chris Lee ,  Mark Anderson

IPC分类号： G06F17/30

CPC分类号： H04L63/0227 ,  G06F17/30864 ,  Y10S707/99936

摘要： A system and method for updating a filtering system which controls access to a website/page between a local area network (LAN) and an Internet. The LAN includes an Internet gateway system coupled to a workstation and configured to receive a URL request. The system controls access to the website/page associated with the URL based on one or more categories that are associated with the URL. The Internet gateway system can determine the category that is associated with the URL by referencing a master database or requesting the category from a database factory. The database factory can receive URLs from multiple Internet gateway systems. The database factory determines whether the identifier was previously categorized by the database factory and provides the category to the Internet gateway system. Once the Internet gateway system has the category, it applies rules associated with the category and user to filter access to the requested website/page.

摘要翻译： 一种用于更新控制对局域网（LAN）和因特网之间的网页/页面的访问的过滤系统的系统和方法。 LAN包括耦合到工作站并被配置为接收URL请求的因特网网关系统。 该系统基于与URL相关联的一个或多个类别来控制对与URL相关联的网站/页面的访问。 互联网网关系统可以通过引用主数据库或从数据库工厂请求类别来确定与URL相关联的类别。 数据库工厂可以从多个互联网网关系统接收URL。 数据库工厂确定该标识符是否以前由数据库工厂分类，并将类别提供给Internet网关系统。 一旦Internet网关系统具有类别，它将应用与该类别和用户相关联的规则来过滤对所请求的网站/页面的访问。

公开(公告)号：US08347949B2

公开(公告)日：2013-01-08

申请号：US13333469

申请日：2011-12-21

申请人： Mark Anderson ,  Todd F. Bischoff ,  James Boorman ,  Wayne J. Fenton ,  David Sinden ,  John Steven Tingey ,  Robert Bruce Wagstaff

发明人： Mark Anderson ,  Todd F. Bischoff ,  James Boorman ,  Wayne J. Fenton ,  David Sinden ,  John Steven Tingey ,  Robert Bruce Wagstaff

IPC分类号： B22D11/049

CPC分类号： B22D11/049 ,  B22D11/10 ,  B22D11/18 ,  B22D11/185 ,  B22D11/186 ,  B22D19/10 ,  B22D41/18

摘要： An exemplary embodiment provides a method of eliminating a shrinkage cavity in a metal ingot cast by direct chill casting. The method involves casting an upright ingot having an upper surface at an intended height. Upon completion of the casting, the lower tip of the spout is maintained below the molten metal near the center of the upper surface. The metal flow through the spout is terminated and a partial shrinkage cavity is allowed to form as metal of the ingot shrinks and contracts. Before the partial cavity exposes the lower tip of the spout, the cavity is preferably over-filled with molten metal, while avoiding spillage of molten metal, and then the flow of metal through the spout is terminated. These steps are repeated until no further contraction of the metal causes any part of the upper surface to contract below the intended ingot height.

摘要翻译： 示例性实施例提供了一种通过直接冷却铸造来消除铸造金属铸锭中的收缩腔的方法。 该方法包括将具有上表面的竖直铸锭铸造在预期高度。 铸造完成时，喷嘴的下端保持在靠近上表面中心的熔融金属的下方。 通过喷口的金属流动被终止，并且允许部分收缩腔形成为金属的锭收缩并收缩。 在部分腔体暴露喷嘴的下端之前，优选地，空腔被熔融金属过度填充，同时避免熔融金属的溢出，然后终止通过喷嘴的金属流。 重复这些步骤，直到金属的进一步收缩导致上表面的任何部分收缩到低于预期的锭高度。

公开(公告)号：US08010552B2

公开(公告)日：2011-08-30

申请号：US11624622

申请日：2007-01-18

申请人： Harold Kester ,  Dan Ruskin ,  Chris Lee ,  Mark Anderson

发明人： Harold Kester ,  Dan Ruskin ,  Chris Lee ,  Mark Anderson

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： H04L63/0227 ,  G06F17/30864 ,  Y10S707/99936

摘要： A system and method for updating a filtering system which controls access to a website/page between a local area network (LAN) and an Internet. The LAN includes an Internet gateway system coupled to a workstation and configured to receive a URL request. The system controls access to the website/page associated with the URL based on one or more categories that are associated with the URL. The Internet gateway system can determine the category that is associated with the URL by referencing a master database or requesting the category from a database factory. The database factory can receive URLs from multiple Internet gateway systems. The database factory determines whether the identifier was previously categorized by the database factory and provides the category to the Internet gateway system. Once the Internet gateway system has the category, it applies rules associated with the category and user to filter access to the requested website/page.

摘要翻译： 一种用于更新控制对局域网（LAN）和因特网之间的网页/页面的访问的过滤系统的系统和方法。 LAN包括耦合到工作站并被配置为接收URL请求的因特网网关系统。 该系统基于与URL相关联的一个或多个类别来控制对与URL相关联的网站/页面的访问。 互联网网关系统可以通过引用主数据库或从数据库工厂请求类别来确定与URL相关联的类别。 数据库工厂可以从多个互联网网关系统接收URL。 数据库工厂确定该标识符是否以前由数据库工厂分类，并将类别提供给Internet网关系统。 一旦Internet网关系统具有类别，它将应用与该类别和用户相关联的规则来过滤对所请求的网站/页面的访问。