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公开(公告)号：US20100076482A1
公开(公告)日：2010-03-25
申请号：US12567243
申请日：2009-09-25
申请人： Mark C. S. Shu , Charles Paul Tabor , Angela Shu
发明人： Mark C. S. Shu , Charles Paul Tabor , Angela Shu
CPC分类号： A61F2/013 , A61F2/01 , A61F2/856 , A61F2/86 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/008
摘要： A device including a stent structure or frame to which a sheet is attached for use in minimizing or preventing emboli, particles. and/or air bubbles from migrating into certain areas of the anatomy. The device can be placed in the blood stream in an area of the heart, such as the aortic arch, to direct particles toward the descending aorta rather than toward the brain. The sheet of the device can be a thin film material, which may include multiple fenestrations that are smaller in size than the particles that are to be filtered.
摘要翻译： 一种包括支架结构或框架的装置，其中连接有片材以用于最小化或防止栓塞，颗粒。 和/或气泡迁移到解剖结构的某些区域。 该装置可以放置在心脏区域（例如主动脉弓）中的血流中，以将颗粒引导到降主动脉而不是朝向大脑。 该装置的片材可以是薄膜材料，其可以包括尺寸小于要被过滤的颗粒的多个开窗。
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公开(公告)号：US07578843B2
公开(公告)日：2009-08-25
申请号：US10404233
申请日：2003-04-01
申请人： Mark C. S. Shu
发明人： Mark C. S. Shu
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2220/0016 , A61F2220/0075 , A61F2250/001 , A61F2250/006
摘要： A heart valve prosthesis has a frame that includes at least one outwardly extending annular flange adjacent to a suturing ring and a band comprising an inwardly extending annular flange that is capable of engagement with the annular flange of the frame. A tortuous path is formed between the annular flange of the frame and the annular flange of the band that can engage and restrain a suture placed between them. One or more split portions or tab portions on the band are adapted to lock the band in engagement with the flange of the frame. Such a device can be used to more easily replace a heart valve by advancing a sutures through a suturing ring on the valve and the valvular rim such that they are brought outward of the flange extending from the frame and then advancing the band over the valve and over the sutures at a proximal, outflow end of the valve until the band engages the flange and captures the sutures between the band and the flange.
摘要翻译： 心脏瓣膜假体具有框架，该框架包括邻近缝合环的至少一个向外延伸的环形凸缘和包括能够与框架的环形凸缘接合的向内延伸的环形凸缘的带。 在框架的环形凸缘和可以接合并限制放置在它们之间的缝合线的带的环形凸缘之间形成曲折的路径。 带上的一个或多个分割部分或突片部分适于将带锁定成与框架的凸缘接合。 这种装置可以用于通过使缝合线穿过阀和瓣膜缘上的缝合环来更容易地替换心脏瓣膜，使得它们被从框架向外延伸，然后将带前进到瓣膜上， 在阀的近端流出端处的缝合线上，直到带接合凸缘并捕获带和凸缘之间的缝合线。
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公开(公告)号：US06372283B1
公开(公告)日：2002-04-16
申请号：US09285953
申请日：1999-04-02
申请人： Hong S. Shim , Mark C. S. Shu , David L. Miller , Edward Di Domenico , Catherine E. Taylor , Kenneth Keeney , Mark T. Stewart , Eileen L. Halverson
发明人： Hong S. Shim , Mark C. S. Shu , David L. Miller , Edward Di Domenico , Catherine E. Taylor , Kenneth Keeney , Mark T. Stewart , Eileen L. Halverson
IPC分类号： B05D306
CPC分类号： A61L33/0088 , A61F2/24 , A61L27/34 , A61L33/0094 , B05D1/62
摘要： The present invention provides a method for modifying a pyrolytic carbon surface to improve adhesion between it and a subsequently added polymer and/or a bio-active compound. In particular, plasma depositing an oxygen-containing, silicon-containing film forming monomer on a pyrolytic carbon surface improves adhesion of a polymer thereto, wherein the modified pyrolytic carbon surface and silicone rubber has a wet adhesion peel force greater than the wet adhesion peel force between an unmodified pyrolytic carbon and silicone rubber as measured by ASTM D 903-49 after 28 days in an aqueous environment, typically, at least 10 times greater.
摘要翻译： 本发明提供了一种改性热解碳表面以改善其与随后加入的聚合物和/或生物活性化合物之间的粘合性的方法。 特别地，在热解碳表面上等离子体沉积含氧的含硅膜形成单体改善了聚合物对其的粘合性，其中改性热解碳表面和硅橡胶具有大于湿粘合剥离力的湿粘合剥离力 在未经改性的热解碳和硅橡胶之间，在水性环境中28天后通过ASTM D 903-49测量，通常为至少10倍以上。
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公开(公告)号：US07172625B2
公开(公告)日：2007-02-06
申请号：US10196527
申请日：2002-07-16
申请人： Mark C. S. Shu , Luis A. Salazar
发明人： Mark C. S. Shu , Luis A. Salazar
CPC分类号： A61F2/2409 , A61F2/2415 , A61F2/2427 , A61F2220/0075 , A61F2250/006 , Y10S623/902
摘要： Suturing rings and methods of use thereof facilitating initial implantation of new and replacement of dysfunctional tissue or mechanical heart valve mechanisms supported by the suturing ring are disclosed. The suturing ring annulus is adjustable to receive and engage the valve frame of the heart valve mechanism within the annulus. An interlocking mechanism applies restraint to fix the adjusted suturing ring annulus engaged against the valve frame to support the heart valve mechanism during chronic implantation. Sutures affixing the suturing ring to the valvar rim can be routed and entrapped between the suturing ring annulus and the valve frame when the suturing ring is restraint is applied. The restraint is released to replace a dysfunctional heart valve mechanism and reapplied when a new heart valve mechanism is fitted into the annulus.
摘要翻译： 公开了缝合环及其使用方法，其便于初始植入由缝合环支撑的功能障碍组织或机械心脏瓣膜机构的新的和替换。 缝合环环可调节以接收和接合环形空间内的心脏瓣膜机构的瓣膜框架。 互锁机构适用于将经过调节的缝合环环固定在阀架上以克服慢性植入期间的心脏瓣膜机制。 当缝合环被施加时，将缝合环固定到瓣膜边缘的缝合线可以被路由并夹在缝合环环和瓣膜框架之间。 释放限制以替代功能失调的心脏瓣膜机制，并且当将新的心脏瓣膜机构装配到环带中时重新应用。
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5.发明授权Composite curvature bileaflet prosthetic heart valve with serpentine curve hinge recesses 失效复合曲率二叉瓣假体心脏瓣膜带蛇形曲线铰链凹槽
公开(公告)号：US5314467A
公开(公告)日：1994-05-24
申请号：US932110
申请日：1992-08-19
申请人： Mark C. S. Shu
发明人： Mark C. S. Shu
CPC分类号： A61F2/2403 , Y10T137/7875 , Y10T137/7898
摘要： A heart valve prosthesis having an annular valve housing or base and two leaflets supported for pivotable movement within the annular valve housing. Each valve leaflet possesses a composite curvature shape with pivoting hinges being purposely offset to the hydraulic force center of the annular valve housing to provide fast response of the leaflets to flow direction change. The hinge mechanism includes modified serpentine curved hinge recesses in the annular valve housing for receiving elongated leaflet ears allowing the leaflets to change their motion modes approaching the closed position to reduce leaflet-edge tangential velocity and impact of the minor edges against one another and the major edges against the housing seat upon closure. The composite curvature leaflets allow maximal central flow with consequent lower pressure drop during the open phase and minimal regurgitation during the closing phase. The curved leaflet major trailing edges in the open position reduces boundary separation and associated turbulence along the flow stream direction.
摘要翻译： 一种具有环形阀壳体或底座的心脏瓣膜假体，以及支撑在环形阀壳体内可枢转运动的两个小叶。 每个瓣叶具有复合曲率形状，其中枢转铰链有意地偏移到环形阀壳体的液压力中心，以提供叶片对流动方向变化的快速响应。 铰链机构包括在环形阀壳体中的改进的蛇形弯曲铰链凹槽，用于接收细长的小叶耳，允许小叶改变其接近关闭位置的运动模式，以减小叶片边缘切向速度和小边缘相对于彼此的冲击， 在关闭时抵靠住座椅的边缘。 复合曲率叶片允许最大的中心流动，从而在开放阶段期间降低压降并且在关闭阶段期间最小的反流。 在开放位置的弯曲小叶主要后缘减少沿着流动流方向的边界分离和相关联的湍流。
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公开(公告)号：US6139575A
公开(公告)日：2000-10-31
申请号：US286095
申请日：1999-04-02
申请人： Mark C. S. Shu , Hong S. Shim , Jeffrey M. Gross
发明人： Mark C. S. Shu , Hong S. Shim , Jeffrey M. Gross
CPC分类号： A61F2/2403
摘要： A prosthetic mechanical heart valve, and in particular, a bi-leaflet and/or a trileaflet mechanical valve formed with rigid frame and hinge elements for providing a stable reliable hinge mechanism with flexible leaflets formed of a thin elastomeric material adhering to and extending from the valve frame to form leaflet occluding sections bounded by outer peripheral edges for softening the opening and closing action of the valve leaflets. In one embodiment, the valve leaflet is formed of a rigid pyrolytic carbon frame supporting hinge elements and defining a leaflet pivot axis and a flexible leaflet body attached to the frame and defining a leaflet abutting section extending from one side of the valve frame and an occluding section extending from the other side of the valve frame to an arcuate leaflet seat. In the closing phase of operation, the abutting sections of the leaflet bodies contact one another in an abutting contact band, and the arcuate leaflet seats bear against arcuate seat regions of the valve body The seat regions of the valve body may also be coated with an elastomeric material.
摘要翻译： 一种假体机械性心脏瓣膜，特别是形成有刚性框架和铰链元件的双叶片和/或三叶形机械阀门，用于提供稳定可靠的铰链机构，该铰链机构具有柔性小叶片，该柔性小叶片由粘附并延伸 阀框架形成由外围边缘限定的小叶闭塞部分，用于软化瓣膜单张的打开和关闭动作。 在一个实施例中，瓣叶由刚性热解碳框架构成，支撑铰链元件并且限定传单枢转轴线和附接到框架的柔性小叶体，并且限定从瓣膜框架的一侧延伸的小叶邻接部分和闭塞 从阀框架的另一侧延伸到弧形小叶座。 在关闭操作阶段，传动体的邻接部分在邻接的接触带处彼此接触，并且弧形小叶座部抵靠阀体的弓形座部区域。阀体的座部区域也可以涂覆有 弹性材料。
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公开(公告)号：US5908450A
公开(公告)日：1999-06-01
申请号：US808553
申请日：1997-02-28
CPC分类号： A61F2/2427 , A61F2/2457 , A61F2250/0097
摘要： A temporary holder for a physiologic mitral valve includes a structure which releasably clamps the annulus of the valve between the rim of a plate and a snap ring. The structure also includes a pair of papillary head holders which hold the papillary heads of the valve at a predetermined distance and angle from the annulus plate for optimum surgical positioning. The papillary heads are temporarily sutured to their holders and can be released by a simple scalpel stroke.
摘要翻译： 用于生理二尖瓣的临时保持器包括可释放地夹持阀的环之间的结构，其在盘的边缘和卡环之间。 该结构还包括一对乳头头保持器，其将瓣膜的乳头头保持与环形板预定的距离和角度，以获得最佳的手术定位。 乳头头临时缝合到其支架上，并可通过简单的解剖刀行程释放。
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