公开(公告)号：US09144667B2

公开(公告)日：2015-09-29

申请号：US13585210

申请日：2012-08-14

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/24 ,  A61M25/10 ,  A61M29/02 ,  A61M25/00

CPC分类号： A61M25/1011 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2250/0048 ,  A61M29/02 ,  A61M2025/0039 ,  A61M2025/004

摘要： A prosthetic valve delivery system for percutaneously delivering and deploying a prosthetic valve within an existing valve is disclosed. The delivery system includes a stented prosthetic valve having a balloon-expandable stent portion with a prosthetic valve disposed therein and at least one self-expanding stent portion. The delivery system further includes a dual balloon catheter having a first balloon on which the stented prosthetic valve is disposed during delivery and a second balloon. Upon delivery within the existing valve, the self-expanding stent portion contacts the existing valve and the first balloon expands the balloon-expandable stent portion to a first diameter such that the stented prosthetic valve is in a first stage deployment configuration. The second balloon then expands the balloon-expandable stent portion to a second diameter, greater than the first diameter, such that the stented prosthetic valve is in a second stage deployment configuration being fully deployed within the existing valve.

摘要翻译： 公开了一种用于在现有阀内经皮递送和展开假体瓣膜的假体瓣膜输送系统。 递送系统包括具有球囊扩张支架部分的支架假体瓣膜，其中设置有人工瓣膜和至少一个自扩张支架部分。 输送系统还包括具有第一气囊的双气囊导管，其中支架假体瓣膜在输送期间设置在其上并具有第二气囊。 在现有阀门内传送后，自膨胀支架部分接触现有阀门，第一气囊将球囊扩张支架部分扩张至第一直径，使得支架假体瓣膜处于第一阶段展开构型。 然后，第二气囊将球囊扩张支架部分扩大到大于第一直径的第二直径，使得支架假体瓣膜处于完全展开在现有瓣膜内的第二阶段展开构型。

公开(公告)号：US08016880B2

公开(公告)日：2011-09-13

申请号：US11941591

申请日：2007-11-16

申请人： Brian Cook ,  Mark Dolan

发明人： Brian Cook ,  Mark Dolan

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

摘要翻译： 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。

公开(公告)号：US07316711B2

公开(公告)日：2008-01-08

申请号：US10694723

申请日：2003-10-29

申请人： Jeffrey Allen ,  Mark Dolan ,  Richard Thomas

发明人： Jeffrey Allen ,  Mark Dolan ,  Richard Thomas

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91541 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0054

摘要： The present invention is an intralumenal stent device made up of two or more elements. Each element has undulations forming peaks and valleys and is formed from a repeating series including a long segment, a first midsized segment, a short segment, and a second midsized segment. These elements are aligned on a common axis and are connected directly to an adjacent element by a connection. The stent incorporates the advantages of having both long and short segments into a single element.

摘要翻译： 本发明是由两个或更多个元件构成的管腔内支架装置。 每个元件具有形成峰和谷的起伏，并且由包括长段，第一中心段，短段和第二中心段的重复序列形成。 这些元件在公共轴线上对准，并通过连接直接连接到相邻元件。 该支架具有将长片段和短片段都组合成单个元件的优点。

公开(公告)号：US20070250161A1

公开(公告)日：2007-10-25

申请号：US11739526

申请日：2007-04-24

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/24

CPC分类号： A61F2/2445 ,  A61F2/2442 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2230/0004 ,  A61F2230/0008

摘要： A catheter based system for treating mitral valve regurgitation includes a reshaping device having a body and a plurality of movable anchoring barbs attached to the body of the device. The reshaping device can be made from a biocompatible material having suitable shape memory properties. The devices of the current invention can be self expandable, balloon expandable, or a combination self expandable and balloon expandable. One embodiment of the invention includes a method for attaching a reshaping device to the annulus of a mitral valve, moving the body of the device from a fully expanded configuration to a resting configuration, and thereby reshaping the mitral valve annulus.

摘要翻译： 用于治疗二尖瓣反流的基于导管的系统包括具有主体的固定装置和附接到装置的主体的多个可动锚定倒钩。 整形装置可以由具有合适形状记忆特性的生物相容性材料制成。 本发明的装置可以是自膨胀的，球囊可膨胀的，或是可自膨胀和气囊扩张的组合。 本发明的一个实施例包括一种用于将整形装置附接到二尖瓣环的方法，将装置的主体从完全展开的构型移动到静止构型，从而重新形成二尖瓣环。

公开(公告)号：US20060089711A1

公开(公告)日：2006-04-27

申请号：US11233592

申请日：2005-09-22

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/24 ,  A61B17/04 ,  A61B17/12

CPC分类号： A61B17/0401 ,  A61B17/00234 ,  A61B17/0487 ,  A61B17/06166 ,  A61B17/12022 ,  A61B2017/00243 ,  A61B2017/00867 ,  A61B2017/0412 ,  A61B2017/0437 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61F2/2487

摘要： A system for reducing a compass of an opening or structure in a mammalian body comprises an anchor having a central aperture, a tensioner having a plurality of openings, and a plurality of filaments, each including a retaining member affixed to a distal portion of the filament. The tensioner is receivable within the anchor central aperture. A proximal portion of each filament is receivable within a tensioner opening. A method of reducing a compass of a lumen or structure in a mammalian body comprises delivering the anchor to a first location proximate target tissue, delivering the filaments to a second location proximate the target tissue, threading the filaments through the anchor and the tensioner openings, positioning the tensioner in the anchor aperture, retaining the filaments in the tensioner, and rotating the tensioner to twist the filaments, thereby shortening the length of the filaments and increasing the tension across the system.

摘要翻译： 用于减少哺乳动物身体中的开口或结构的罗盘的系统包括具有中心孔的锚固件，具有多个开口的张紧器和多个长丝，每个细丝包括固定在丝线的远端部分上的保持构件 。 张紧器可在锚定中心孔内接收。 每个细丝的近端部分可接收在张紧器开口内。 减少哺乳动物体内的内腔或结构的罗盘的方法包括将锚固件传送到靠近目标组织的第一位置，将细丝递送到靠近目标组织的第二位置，将细丝穿过锚固件和张紧器开口， 将张紧器定位在锚定孔中，将长丝保持在张紧器中，并且使张紧器旋转以扭曲长丝，由此缩短长丝并增加整个系统的张力。

公开(公告)号：US20060085012A1

公开(公告)日：2006-04-20

申请号：US10952603

申请日：2004-09-28

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/36

CPC分类号： A61F2/2445 ,  A61B17/00234 ,  A61B17/8875 ,  A61B17/888 ,  A61F2/2466

摘要： The invention provides an endovascular torquing device for a rotational fastener and a system and method for endovascular delivery of a rotational fastener to a treatment site within a patient. The torquing device comprises a flexible body portion having a guidewire lumen extending longitudinally there through. A coupling portion formed on a distal end of the body portion interfaces with a rotational fastener positioned within a vessel. The system comprises a guide catheter, at least one guidewire, at least one rotational fastener disposed on the guidewire, and a torquing device. The guide catheter is positioned adjacent to a treatment site, and the rotational fastener and guidewire are delivered through the guide catheter to the treatment site. The torquing device, which has a guidewire lumen extending longitudinally through at least a portion of the device, tracks over the guidewire to engage and rotate the fastener.

摘要翻译： 本发明提供了一种用于旋转紧固件的血管内扭力装置和用于将旋转紧固件的血管内递送到患者体内的治疗部位的系统和方法。 扭力装置包括柔性主体部分，其具有沿着其延伸穿过的导丝管腔。 形成在主体部分的远端上的联接部分与位于容器内的旋转紧固件相接触。 所述系统包括导向导管，至少一个导丝，设置在所述导丝上的至少一个旋转紧固件和扭力装置。 引导导管邻近治疗部位定位，旋转紧固件和导丝通过引导导管输送到治疗部位。 具有沿着装置的至少一部分纵向延伸的导丝管的扭力装置在引导线上方跟踪以接合和旋转紧固件。

公开(公告)号：US20060030922A1

公开(公告)日：2006-02-09

申请号：US10911931

申请日：2004-08-05

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/06

CPC分类号： A61F2/958

摘要： Intraluminal stent assemblies and methods of deploying the same. The assemblies include a catheter including at least one lumen formed therein. At least one inflatable member is disposed on the catheter and in communication with the lumen. The inflatable member includes at least one distal projection and/or at least one retention material. A stent is expandable from a compressed configuration to an expanded configuration. The stent is disposed on the inflatable member in the compressed configuration. A sheath is slidably positioned over the stent wherein the stent expands to the expanded configuration upon retraction of the sheath. The inflatable member is inflated with a fluid flowing through the lumen. The at least one distal projection and/or at least one retention material retain the stent in position on the inflatable member while the stent is being deployed.

摘要翻译： 管腔内支架组件及其部署方法。 组件包括其中形成有至少一个内腔的导管。 至少一个可充气构件设置在导管上并与内腔连通。 可膨胀构件包括至少一个远端突出部和/或至少一个保持材料。 支架可从压缩构型扩展到扩张构型。 支架以压缩构型设置在可膨胀构件上。 护套可滑动地定位在支架上，其中支架在收缩护套时扩张到扩张构型。 充气构件用流过管腔的流体充气。 当支架被展开时，至少一个远端突出部和/或至少一个保持材料将支架保持在可充气构件上的适当位置。

公开(公告)号：US08328867B2

公开(公告)日：2012-12-11

申请号：US11760499

申请日：2007-06-08

申请人： Mark Dolan ,  Susan Rea ,  John Kantor

发明人： Mark Dolan ,  Susan Rea ,  John Kantor

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2230/0054 ,  A61F2250/0068

摘要： A drug eluting implantable device includes an exterior surface on the device and at least one recess formed in the exterior surface. The device further include at least one sidewall protruding from the exterior surface adjacent the at least one recess defining a channel with the recess into which the drug may be loaded, the sidewall including a perpendicular portion substantially perpendicular to the exterior surface and the sidewall further including a parallel portion extending from the perpendicular portion, the parallel portion extending from the perpendicular portion at an angle greater than about 90 degrees as measured with reference to the exterior surface.

摘要翻译： 药物洗脱可植入装置包括装置上的外表面和形成在外表面中的至少一个凹部。 所述装置还包括至少一个侧壁，所述至少一个侧壁从邻近所述至少一个凹部的所述外表面突出，所述至少一个凹槽限定与所述凹部的通道，所述凹部可被装载到所述凹部中，所述侧壁包括基本上垂直于所述外表面的垂直部分， 从所述垂直部分延伸的平行部分，所述平行部分以相对于所述外表面测量的大于约90度的角度从所述垂直部分延伸。

公开(公告)号：US08273120B2

公开(公告)日：2012-09-25

申请号：US13210675

申请日：2011-08-16

申请人： Mark Dolan

发明人： Mark Dolan

IPC分类号： A61F2/24

CPC分类号： A61M25/1011 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2250/0048 ,  A61M29/02 ,  A61M2025/0039 ,  A61M2025/004

摘要： A prosthetic valve delivery system for percutaneously delivering and deploying a prosthetic valve within an existing valve is disclosed. The delivery system includes a stented prosthetic valve having a balloon-expandable stent portion with a prosthetic valve disposed therein and at least one self-expanding stent portion. The delivery system further includes a dual balloon catheter having a first balloon on which the stented prosthetic valve is disposed during delivery and a second balloon. Upon delivery within the existing valve, the self-expanding stent portion contacts the existing valve and the first balloon expands the balloon-expandable stent portion to a first diameter such that the stented prosthetic valve is in a first stage deployment configuration. The second balloon then expands the balloon-expandable stent portion to a second diameter, greater than the first diameter, such that the stented prosthetic valve is in a second stage deployment configuration being fully deployed within the existing valve.

摘要翻译： 公开了一种用于在现有阀内经皮递送和展开假体瓣膜的假体瓣膜输送系统。 输送系统包括支架假体瓣膜，其具有球囊扩张支架部分，其中设置有人工瓣膜和至少一个自扩张支架部分。 输送系统还包括具有第一气囊的双气囊导管，其中支架假体瓣膜在输送期间设置在其上并具有第二气囊。 在现有阀门内传送后，自膨胀支架部分接触现有阀门，第一气囊将球囊扩张支架部分扩张至第一直径，使得支架假体瓣膜处于第一阶段展开构型。 然后，第二气囊将球囊扩张支架部分扩大到大于第一直径的第二直径，使得支架假体瓣膜处于完全展开在现有瓣膜内的第二阶段展开构型。

公开(公告)号：US20080306579A1

公开(公告)日：2008-12-11

申请号：US11760499

申请日：2007-06-08

申请人： Mark Dolan ,  Susan Rea ,  John Kantor

发明人： Mark Dolan ,  Susan Rea ,  John Kantor

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2230/0054 ,  A61F2250/0068

摘要： A drug eluting implantable device includes an exterior surface on the device and at least one recess formed in the exterior surface. The device further include at least one sidewall protruding from the exterior surface adjacent the at least one recess defining a channel with the recess into which the drug may be loaded, the sidewall including a perpendicular portion substantially perpendicular to the exterior surface and the sidewall further including a parallel portion extending from the perpendicular portion, the parallel portion extending from the perpendicular portion at an angle greater than about 90 degrees as measured with reference to the exterior surface

摘要翻译： 药物洗脱可植入装置包括装置上的外表面和形成在外表面中的至少一个凹部。 所述装置还包括至少一个侧壁，所述至少一个侧壁从邻近所述至少一个凹部的所述外表面突出，所述至少一个凹槽限定与所述凹部的通道，所述凹部可被装载到所述凹部中，所述侧壁包括基本上垂直于所述外表面的垂直部分， 从垂直部分延伸的平行部分，平行部分从垂直部分以大于约90度的角度延伸，如参照外表面