公开(公告)号：US08016880B2

公开(公告)日：2011-09-13

申请号：US11941591

申请日：2007-11-16

申请人： Brian Cook ,  Mark Dolan

发明人： Brian Cook ,  Mark Dolan

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

摘要翻译： 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。

公开(公告)号：US20090132031A1

公开(公告)日：2009-05-21

申请号：US11941591

申请日：2007-11-16

申请人： Brian Cook ,  Mark Dolan

发明人： Brian Cook ,  Mark Dolan

IPC分类号： A61F2/82

CPC分类号： A61F2/88 ,  A61F2/86 ,  A61F2250/0035 ,  A61F2250/0068

摘要： A drug delivery stent is formed by a metallic or polymeric tubular strut which is shaped into a generally cylindrical configuration, the tubular strut having a central lumen for containing a therapeutic substance or drug therein. The tubular strut has a continuous channel extending from the inside surface of the strut to the outside surface of the strut positioned spirally about or in a corkscrew fashion around a circumference of the tubular strut for delivering the therapeutic substance or drug to a stenotic lesion. The spiral or corkscrew channel width may be varied along the length of the strut to control elution rate and/or flexibility of the stent. The pitch of the spiral or corkscrew channel may also be varied along the length of the strut to control flexibility of the stent. The stent may be carried on a balloon of a balloon catheter to a site of a stenotic lesion where the stent is implanted.

摘要翻译： 药物递送支架由金属或聚合物管状支柱形成，其形状为大致圆柱形的构造，管状支柱具有用于在其中容纳治疗物质或药物的中心腔。 管状支柱具有从支柱的内表面延伸到支柱的外表面的连续通道，所述支柱的外表面围绕螺旋状围绕或以开瓶器方式围绕管状支柱的圆周定位，用于将治疗物质或药物输送至狭窄病变。 螺旋或螺旋状通道宽度可以沿着支柱的长度变化以控制支架的洗脱速率和/或柔性。 螺旋或螺旋状通道的螺距也可以沿着支柱的长度变化以控制支架的柔性。 支架可以携带在球囊导管的球囊上，以移植支架的狭窄病变部位。

公开(公告)号：US09714941B2

公开(公告)日：2017-07-25

申请号：US12183916

申请日：2008-07-31

申请人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

发明人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

IPC分类号： G01N33/543

CPC分类号： G01N33/54366 ,  G01N2333/726

摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

公开(公告)号：US08998274B2

公开(公告)日：2015-04-07

申请号：US13211209

申请日：2011-08-16

申请人： David A. Fehr ,  Wayne A. Knepp ,  Brian Cook

发明人： David A. Fehr ,  Wayne A. Knepp ,  Brian Cook

IPC分类号： E05C3/04 ,  E05B65/08 ,  E05C17/60 ,  E05C19/04 ,  E05C19/00 ,  E05C9/00 ,  E05C19/10 ,  E05C19/12 ,  E05C5/00 ,  E05B53/00 ,  E05C17/48

CPC分类号： E05B65/0817 ,  E05B53/003 ,  E05B65/0882 ,  E05C17/48 ,  E05C17/60 ,  E05C19/04 ,  Y10T292/03 ,  Y10T292/0807 ,  Y10T292/0911 ,  Y10T292/0915 ,  Y10T292/0917 ,  Y10T292/1084

摘要： A sliding door latching and locking system is disclosed which includes a latch assembly, a lift rod assembly, and a retainer assembly, among other things. In some embodiments, the latch assembly includes a support member mounted in a movable body and a latching arm pivotally mounted to the support member having a distal end thereof extending outside of the periphery of the movable body, wherein the distal end includes an engagement facilitating portion with a sloped outer surface for contacting an interlocking member.

摘要翻译： 公开了一种滑动门闩锁和锁定系统，其包括闩锁组件，提升杆组件和保持器组件等。 在一些实施例中，闩锁组件包括安装在可移动体中的支撑构件和可枢转地安装到支撑构件的闩锁臂，该支撑构件的远端延伸到可移动体的周边的外部，其中远端包括接合促进部分 具有用于接触互锁构件的倾斜的外表面。

公开(公告)号：US08748111B2

公开(公告)日：2014-06-10

申请号：US13015851

申请日：2011-01-28

申请人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

发明人： Andreas Mershin ,  Brian Cook ,  Liselotte Kaiser ,  Johanna F. Bikker ,  Yoshikatsu Miura ,  Daisuke Niwa ,  Dai Ohnishi ,  Atsushi Tazuke ,  Shuguang Zhang

IPC分类号： G01N33/53 ,  C07K2/00 ,  B82Y30/00 ,  G01N33/00 ,  G01N21/55

CPC分类号： G01N21/553 ,  B82Y30/00 ,  C07K2/00 ,  G01N21/554 ,  G01N33/0031 ,  G01N2201/06113 ,  G01N2201/08

摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

摘要翻译： 本发明提供了一种生物感测纳米装置，其包括：载体上的稳定的G-蛋白偶联受体，实时受体 - 配体结合检测方法，测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其含有固定在载体上的稳定化的G蛋白偶联受体，并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

公开(公告)号：US08669041B2

公开(公告)日：2014-03-11

申请号：US13183558

申请日：2011-07-15

申请人： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

发明人： Brian Cook ,  David A. Recchia ,  Timothy Gotsick

IPC分类号： G03F7/00 ,  G03F7/26 ,  B41N1/00

CPC分类号： G03F7/092 ,  G03F7/202

摘要： A method of making a relief image printing element having a relief pattern comprising a plurality of relief dots, wherein the photocurable printing blank comprises a backing layer having at least one photocurable layer disposed thereon and a masking layer on the at least one photocurable layer is provided. The method comprising the steps of: a) selectively ablating the masking layer to create an overall image in the masking layer, such that the overall image comprises a sub-image, comprising a pattern of cells, in it; b) applying an oxygen barrier layer on top of the masking layer; c) exposing the printing element to actinic radiation through the oxygen barrier layer and the masking layer; and d) developing the printing blank by removing the barrier layer and the uncured portions of the photocurable layer to reveal the relief image.

摘要翻译： 一种形成具有包括多个浮雕点的浮雕图案的浮雕图像打印元件的方法，其中所述光固化印刷坯料包括其上设置有至少一个光固化层的背衬层，并且在所述至少一个光固化层上设置掩模层 。 该方法包括以下步骤：a）选择性地烧蚀掩模层以在掩模层中产生整体图像，使得整个图像包括其中包含单元格图案的子图像; b）在掩蔽层的顶部上施加氧阻挡层; c）将印刷元件暴露于通过氧阻隔层和掩蔽层的光化辐射; 以及d）通过去除光固化层的阻挡层和未固化部分来显影印刷毛坯以露出浮雕图像。

公开(公告)号：US20070076082A1

公开(公告)日：2007-04-05

申请号：US11241094

申请日：2005-09-30

申请人： Brian Cook

发明人： Brian Cook

IPC分类号： B41J3/36

CPC分类号： B41J3/36 ,  B41J11/003

摘要： The size of a print area may be determined using a hand-held printer including an internal tracking device, such as an optical mouse device. Based on the size of the print area, and one or more user settings, an image to be printed on the print surface by the hand-held printer may be scaled and/or repositioned. The hand-held printer may print the image to a desired size while centering the image or otherwise repositioning it, scaling it to fit within user-defined margins or areas, and the like.

摘要翻译： 可以使用包括诸如光学鼠标装置的内部跟踪装置的手持式打印机来确定打印区域的尺寸。 基于打印区域的大小和一个或多个用户设置，可以缩放和/或重新定位由手持打印机在打印表面上打印的图像。 手持打印机可以将图像打印到期望的尺寸，同时使图像居中或以其它方式重新定位，将其缩放以适合用户定义的边缘或区域等。

公开(公告)号：US09069255B2

公开(公告)日：2015-06-30

申请号：US12620715

申请日：2009-11-18

申请人： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

发明人： Jim Hennessy ,  David X. Elwell ,  Nicholas R. Pina ,  Brian Cook ,  Ryan Vest

IPC分类号： B41N6/00 ,  B41N10/02 ,  G03F7/34 ,  B41F27/00

CPC分类号： G03F7/34 ,  B41F27/00 ,  B41N6/00 ,  B41N10/02

摘要： An improved apparatus for thermally developing a flexographic printing element to reveal a relief image on the surface and a method of using the apparatus to develop a flexographic printing element. The apparatus typically comprises means for softening or melting a crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; at least one roll that is contactable with the imaged surface of the flexographic printing element and capable of moving over at least a portion of the imaged surface of the flexographic printing element to remove the softened or melted non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element; and means for maintaining contact between the at least one roll and the imaged and exposed surface of the flexographic printing element. A layer of resilient compressible material is positioned between the flexographic printing element and a supporting conveying means. The means for softening or melting non-crosslinked photopolymer on the imaged and exposed surface of the flexographic printing element comprise a heater positioned adjacent to the imaged surface of the flexographic printing element and/or heating the at least one roll that contactable with the imaged surface of the flexographic printing element. The apparatus may also contain an exposure device to crosslink and cure the imaged surface of the flexographic printing element prior to thermal development.

摘要翻译： 用于热显影柔性版印刷元件以在表面上露出浮雕图像的改进的装置以及使用该装置来开发柔性版印刷元件的方法。 该装置通常包括用于软化或熔化柔性版印刷元件的成像和暴露表面上的交联光聚合物的装置; 至少一个辊，其能够与柔性版印刷元件的成像表面接触并且能够移动柔性版印刷元件的成像表面的至少一部分以去除成像和曝光表面上的软化或熔融的非交联光聚合物 的柔性版印刷元件; 以及用于保持柔性版印刷元件的至少一个辊与成像和暴露的表面之间的接触的装置。 弹性可压缩材料层位于柔性版印刷元件和支撑输送装置之间。 用于软化或熔化柔性版印刷元件的成像和暴露表面上的非交联光聚合物的装置包括邻近柔性版印刷元件的成像表面定位的加热器和/或加热可与成像表面接触的至少一个辊 的柔性版印刷元件。 该装置还可以包含用于在热显影之前交联和固化柔性版印刷元件的成像表面的曝光装置。

公开(公告)号：US20100211153A1

公开(公告)日：2010-08-19

申请号：US12389070

申请日：2009-02-19

申请人： Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

发明人： Brian Cook ,  James Mitchell ,  Natividad Vasquez ,  Gianfranco Pellegrini

IPC分类号： A61F2/84

CPC分类号： A61M25/0082 ,  A61F2/91 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/9665 ,  A61F2250/0068 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0681

摘要： A system for treating a vascular condition includes a catheter having an inner member and an outer member, the outer member concentrically arranged about the inner member and a retractable drug delivery device disposed at a distal end of the inner member. A coating disposed on at least a portion of an outer surface of the retractable drug delivery device includes at least one therapeutic agent.

摘要翻译： 用于治疗血管病症的系统包括具有内部构件和外部构件的导管，所述外部构件围绕内部构件同心地布置，以及设置在内部构件的远端处的可伸缩药物输送装置。 设置在可伸缩药物输送装置的外表面的至少一部分上的涂层包括至少一种治疗剂。

公开(公告)号：US20090156427A1

公开(公告)日：2009-06-18

申请号：US12183916

申请日：2008-07-31

申请人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

发明人： Shuguang Zhang ,  Andreas Mershin ,  Liselotte Kaiser ,  Brian Cook ,  Johanna F. Graveland-Bikker ,  Manu Prakash ,  David Kong ,  Yael Maguire

IPC分类号： C40B30/10 ,  B01J19/00 ,  C40B40/10 ,  C40B60/12 ,  C40B30/00 ,  C12P21/00

CPC分类号： G01N33/54366 ,  G01N2333/726

摘要： The invention provides a bio-sensing nanodevice comprising: a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—on a support, a real time receptor-ligand binding detection method, an odorant delivery system and an odorant recognition program. The biologically-derived G-protein coupled receptor can be stabilized on nanotechnology using surfactant peptide. The said nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized biologically-derived G-protein coupled receptor—the olfactory receptor—immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

摘要翻译： 本发明提供一种生物感测纳米装置，其包括：稳定的生物衍生的G蛋白偶联受体 - 支持物上的嗅觉受体，实时受体 - 配体结合检测方法，加味剂递送系统和气味识别程序。 生物衍生的G蛋白偶联受体可以使用表面活性剂肽在纳米技术上稳定。 所述纳米器件提供更大的表面积，以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片，其包含稳定的生物衍生的G蛋白偶联受体 - 嗅觉受体 - 固定在载体上，并且布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法，其包括在复杂微流体网络中操作气泡的步骤，其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。