公开(公告)号：US09682372B2

公开(公告)日：2017-06-20

申请号：US12487962

申请日：2009-06-19

申请人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

发明人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

IPC分类号： B01L3/02

CPC分类号： B01L3/0268 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887

摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

公开(公告)号：US20140171342A1

公开(公告)日：2014-06-19

申请号：US14026705

申请日：2013-09-13

申请人： Bruce K. Gale ,  Joshua W. Eckman ,  Adam Miles ,  Christopher Morrow ,  James Smith ,  Sriram Natarajan ,  Mark Eddings

发明人： Bruce K. Gale ,  Joshua W. Eckman ,  Adam Miles ,  Christopher Morrow ,  James Smith ,  Sriram Natarajan ,  Mark Eddings

IPC分类号： B01J19/00

CPC分类号： B01J19/0046 ,  B01J2219/00385 ,  B01J2219/00387 ,  B01J2219/00418 ,  B01J2219/00527 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00734 ,  B01J2219/0074 ,  B01J2219/00743 ,  B01L3/0289 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2400/022 ,  B01L2400/0487

摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter for depositing a substance on a submerged surface. The spotter comprises an outlet cavity defined at least in part by a spotting orifice, a first opening, and a second opening. The spotter also comprises a first conduit fluidly coupled to the first opening and a second conduit fluidly coupled to the second opening. The spotter is adapted so that fluid flowing through the first conduit and the second conduit is communicated among the first opening, the second opening, and a submerged deposition surface when the sealing orifice is sealed against the submerged deposition surface to form a deposition spot on the submerged deposition surface. The submerged deposition surface is within a liquid such that the liquid covers the deposition spot upon removal of the orifice from the deposition surface.

摘要翻译： 本公开提供了涉及用于将物质沉积在浸没表面上的点样器的装置，系统和方法。 识别器包括至少部分地由点样孔，第一开口和第二开口限定的出口腔。 点样器还包括流体地联接到第一开口的第一导管和流体地联接到第二开口的第二导管。 调色剂适于使得当密封孔密封在浸没沉积表面上时，流过第一导管和第二导管的流体在第一开口，第二开口和浸没沉积表面之间连通，以形成沉积点 浸没沉积表面。 浸没沉积表面在液体内，使得液体在从沉积表面移除孔口时覆盖沉积点。

公开(公告)号：US20100248994A1

公开(公告)日：2010-09-30

申请号：US12487962

申请日：2009-06-19

申请人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

发明人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

IPC分类号： C40B50/18 ,  C40B60/14

CPC分类号： B01L3/0268 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887

摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

摘要翻译： 本公开提供了涉及用于将物质从载体流体以有序阵列沉积到沉积表面上的识别装置的装置，系统和方法，所述定位装置包括包括第一井和第二井的装载表面; 以及不同的出口表面，包括第一开口和第二开口，其中第一微管将第一孔与第一开口流体耦合，而第二微管将第二孔与第二开口流体耦合。 当覆盖层压靠在沉积表面上时，覆盖层被密封到出口表面并被沉积通道穿透，所述沉积通道被定位成在第一开口，第二开口和沉积表面之间连通载体流体。