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    Tip overlay for continuous flow spotting apparatus
    3.
    发明申请
    Tip overlay for continuous flow spotting apparatus 有权
    连续流动点样装置的尖端覆盖

    公开(公告)号：US20100248994A1

    公开(公告)日：2010-09-30

    申请号：US12487962

    申请日：2009-06-19

    申请人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

    发明人： Bruce K. Gale ,  Adam Miles ,  Joshua Wayne Eckman ,  Sriram Natarajan ,  Jim Smith ,  Mark Eddings

    IPC分类号： C40B50/18 ,  C40B60/14

    CPC分类号： B01L3/0268 ,  B01J2219/00385 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0874 ,  B01L2300/0887

    摘要： The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

    摘要翻译： 本公开提供了涉及用于将物质从载体流体以有序阵列沉积到沉积表面上的识别装置的装置，系统和方法，所述定位装置包括包括第一井和第二井的装载表面; 以及不同的出口表面，包括第一开口和第二开口，其中第一微管将第一孔与第一开口流体耦合，而第二微管将第二孔与第二开口流体耦合。 当覆盖层压靠在沉积表面上时，覆盖层被密封到出口表面并被沉积通道穿透，所述沉积通道被定位成在第一开口，第二开口和沉积表面之间连通载体流体。

    Microfluidic interface for highly parallel addressing of sensing arrays
    4.
    发明授权
    Microfluidic interface for highly parallel addressing of sensing arrays 有权
    用于感测阵列高度并行寻址的微流体接口

    公开(公告)号：US08383059B2

    公开(公告)日：2013-02-26

    申请号：US11241060

    申请日：2005-09-30

    申请人： David A. Chang-Yen ,  Sriram Natarajan ,  Josh Eckman ,  Bruce K. Gale ,  David Myszka

    发明人： David A. Chang-Yen ,  Sriram Natarajan ,  Josh Eckman ,  Bruce K. Gale ,  David Myszka

    IPC分类号： B01L3/00

    CPC分类号： G01N33/553 ,  B01J19/0046 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/021 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2400/0487 ,  C12N15/1093 ,  G01N35/1074 ,  G01N2035/00158 ,  G01N2035/1039 ,  Y10T436/2575

    摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.

    摘要翻译： 公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。 斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。 它也可以用于在同一点上执行各种化学步骤。 点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。 识别器可以由井板处理设备装载。 点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。 每个孔通过微管连接到两个孔。 当检测器接触表面时，在孔和表面之间形成密封。 相同或不同的物质可能流过每个孔口。 任何数量的孔口都可以并入到一个定点器中。 鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

    Method for measuring strength of associations of multidimensional traits
    5.
    发明授权
    Method for measuring strength of associations of multidimensional traits 有权

    公开(公告)号：US10242753B2

    公开(公告)日：2019-03-26

    申请号：US11465729

    申请日：2006-08-18

    申请人： Anthony G. Greenwald ,  Sriram Natarajan

    发明人： Anthony G. Greenwald ,  Sriram Natarajan

    IPC分类号： G09B7/00 ,  G16H10/20 ,  A61B5/16

    摘要： A method of measuring a subject's strength of associations of multidimensional traits involving each of a first pair of first and second categories with each of a second pair of third and fourth categories includes selecting a first target concept for the first category and a second target concept for the second category and selecting a first trait for the third category and, for the fourth category, a plurality of alternative traits to provide a basis for contrasting with the first trait. The method further includes having the subject respond to a first set of trials in a first manner when there is presented an exemplar of either the first category or the third category and in a second manner when there is presented an exemplar of either the second category or the fourth category and presenting the subject with a first series of exemplars in the first set of trials, the first series including exemplars in all four categories. The method further includes having the subject respond to a second set of trials in one of the two manners when there is presented the exemplar of either the second category or the third category and in the other of the two manners when there is presented the exemplar of either the first category or the fourth category and presenting the subject with a second series of exemplars in the second set of trials, the second series including exemplars in all four categories. Latency is measured in each trial from time of exemplar presentation to the subject to a response by the subject to produce latency measurements. A measure is calculated of the subject's strength of associations involving each of the first and second categories with each of the third and fourth categories from the latency measurements.