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    Method and apparatus for mechanical stimulation of tissue in vitro
    1.
    发明申请
    Method and apparatus for mechanical stimulation of tissue in vitro 失效
    体外机械刺激组织的方法和装置

    公开(公告)号：US20060129071A1

    公开(公告)日：2006-06-15

    申请号：US11284146

    申请日：2005-11-21

    申请人： Hans Hauselmann ,  Markus Muser ,  Peter Niederer ,  Martin Stoddart ,  Erik Hedbom

    发明人： Hans Hauselmann ,  Markus Muser ,  Peter Niederer ,  Martin Stoddart ,  Erik Hedbom

    IPC分类号： A61H1/00

    CPC分类号： A61L27/28 ,  A61K35/12 ,  A61L27/3817 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C08L5/08 ,  C12N5/0062 ,  C12N5/0655 ,  C12N2500/34

    摘要： The invention concerns a method and an apparatus for mechanical stimulation in vitro of tissue, wherein tissue patches (1) are retained in a tissue carrier (2), thereby presenting first surfaces (3) to be stimulated in a plane (X) and wherein a roller (4) having a second surface (5) arranged at its periphery is moved parallel to said plane (X), thereby imposing selected forces on said first surfaces (3) by said second surface (5) for stimulating the tissue patches (1). By presenting the surfaces (3) to be stimulated in a common plane (X) and by moving the roller (4) parallel to said common plane (X) of the first surfaces (3), serving several tissue carriers (2) with one roller (4) is made easy, thus integration into an industrial production is made practicable.

    摘要翻译： 本发明涉及一种用于体外机械刺激组织的方法和装置，其中组织块（1）保留在组织载体（2）中，从而呈现要在平面（X）中被刺激的第一表面（3），并且其中 具有布置在其周边的第二表面（5）的辊（4）平行于所述平面（X）移动，从而通过所述第二表面（5）对所述第一表面（3）施加选定的力，以刺激组织块（ 1）。 通过使待激发在公共平面（X）中的表面（3）和平行于第一表面（3）的所述公共平面（X）的辊（4）移动，用一个组织载体（2） 辊（4）变得容易，因此整合到工业生产中是可行的。

    Preparing a homogenous population of stem cells committed to differentiated to a specific cell type
    2.
    发明授权
    Preparing a homogenous population of stem cells committed to differentiated to a specific cell type 有权
    准备致病分化为特定细胞类型的干细胞的均匀群体

    公开(公告)号：US08557584B2

    公开(公告)日：2013-10-15

    申请号：US12089494

    申请日：2006-08-11

    申请人： Mauro Alini ,  Martin Stoddart

    发明人： Mauro Alini ,  Martin Stoddart

    IPC分类号： C12N15/00 ,  C12N5/00

    CPC分类号： C12N5/0663 ,  C12N2510/00 ,  C12N2799/021

    摘要： The stem cell (1) includes a cellular DNA (2) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule (3) generated by means of a specific stimulus (12) and at least one DNA-molecule (6) artificially introduced into the stem cell (1).The artificially introduced DNA-molecule (6) comprises at least one binding site sequence (30) being apt to interact with the protein molecule (3), at least one DNA-sequence (40) coding an indicator molecule (5) and at least one minimal promoter sequence (50), allowing the gene expression of said indicator molecule (5), whereby the stem cell further includes at least one indicator molecule (5) having properties allowing its identification and is produced by synthesis of the DNA-sequence (40) coding an indicator molecule (5) of the artificially introduced DNA-molecule (6).

    摘要翻译： 干细胞（1）包括细胞DNA（2），其包含编码不同基因的多个序列和允许DNA-蛋白质相互作用的启动子，至少一种通过特定刺激（12）产生的蛋白质分子（3）和 至少一个DNA分子（6）人工引入干细胞（1）。 人造引入的DNA分子（6）包含至少一个易于与蛋白质分子（3）相互作用的结合位点序列（30），至少一个编码指示分子（5）的DNA序列（40）和至少 一个最小启动子序列（50），允许所述指示剂分子（5）的基因表达，由此所述干细胞还包括至少一个具有允许其鉴定并具有通过合成DNA序列产生的特征的指示剂分子（5） 40）编码人造引入的DNA分子（6）的指示剂分子（5）。

    Method and apparatus for mechanical stimulation of tissue in vitro
    3.
    发明授权
    Method and apparatus for mechanical stimulation of tissue in vitro 失效
    体外机械刺激组织的方法和装置

    公开(公告)号：US07772000B2

    公开(公告)日：2010-08-10

    申请号：US11284146

    申请日：2005-11-21

    申请人： Hans Jörg Häuselmann ,  Markus Muser ,  Peter Niederer ,  Martin Stoddart ,  Erik Hedbom

    发明人： Hans Jörg Häuselmann ,  Markus Muser ,  Peter Niederer ,  Martin Stoddart ,  Erik Hedbom

    IPC分类号： C12N5/00 ,  C12M1/00

    CPC分类号： A61L27/28 ,  A61K35/12 ,  A61L27/3817 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C08L5/08 ,  C12N5/0062 ,  C12N5/0655 ,  C12N2500/34

    摘要： The invention concerns a method and an apparatus for mechanical stimulation in vitro of tissue, wherein tissue patches (1) are retained in a tissue carrier (2), thereby presenting first surfaces (3) to be stimulated in a plane (X) and wherein a roller (4) having a second surface (5) arranged at its periphery is moved parallel to said plane (X), thereby imposing selected forces on said first surfaces (3) by said second surface (5) for stimulating the tissue patches (1). By presenting the surfaces (3) to be stimulated in a common plane (X) and by moving the roller (4) parallel to said common plane (X) of the first surfaces (3), serving several tissue carriers (2) with one roller (4) is made easy, thus integration into an industrial production is made practicable.

    摘要翻译： 本发明涉及一种用于体外机械刺激组织的方法和装置，其中组织块（1）保留在组织载体（2）中，从而呈现要在平面（X）中被刺激的第一表面（3），并且其中 具有布置在其周边的第二表面（5）的辊（4）平行于所述平面（X）移动，从而通过所述第二表面（5）对所述第一表面（3）施加选定的力，以刺激组织块（ 1）。 通过使待激发在公共平面（X）中的表面（3）和平行于第一表面（3）的所述公共平面（X）的辊（4）移动，用一个组织载体（2） 辊（4）变得容易，因此整合到工业生产中是可行的。

    IDENTIFICATION AND SELECTION OF STEM CELLS BEING COMMITTED TO DIFFERENTIATE TO A SPECIFIC TYPE FOR OBTAINING A HOMOGENEOUS POPULATION OF STEM CELLS
    4.
    发明申请
    IDENTIFICATION AND SELECTION OF STEM CELLS BEING COMMITTED TO DIFFERENTIATE TO A SPECIFIC TYPE FOR OBTAINING A HOMOGENEOUS POPULATION OF STEM CELLS 有权
    确定和选择干细胞分化为特异性类型以获得干细胞的均质群体

    公开(公告)号：US20090304652A1

    公开(公告)日：2009-12-10

    申请号：US12089494

    申请日：2006-08-11

    申请人： Mauro Alini ,  Martin Stoddart

    发明人： Mauro Alini ,  Martin Stoddart

    IPC分类号： A61K35/12 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68 ,  C12N15/85 ,  A61P7/00 ,  A61P17/00 ,  C12N5/00

    CPC分类号： C12N5/0663 ,  C12N2510/00 ,  C12N2799/021

    摘要： The stem cell (1) includes a cellular DNA (2) comprising a plurality of sequences coding different genes and promoters allowing DNA-protein-interactions, at least one protein molecule (3) generated by means of a specific stimulus (12) and at least one DNA-molecule (6) artificially introduced into the stem cell (1).The artificially introduced DNA-molecule (6) comprises at least one binding site sequence (30) being apt to interact with the protein molecule (3), at least one DNA-sequence (40) coding an indicator molecule (5) and at least one minimal promoter sequence (50), allowing the gene expression of said indicator molecule (5), whereby the stem cell further includes at least one indicator molecule (5) having properties allowing its identification and is produced by synthesis of the DNA-sequence (40) coding an indicator molecule (5) of the artificially introduced DNA-molecule (6).

    摘要翻译： 干细胞（1）包括细胞DNA（2），其包含编码不同基因的多个序列和允许DNA-蛋白质相互作用的启动子，至少一种通过特定刺激（12）产生的蛋白质分子（3）和 至少一个DNA分子（6）人工引入干细胞（1）。 人造引入的DNA分子（6）包含至少一个易于与蛋白质分子（3）相互作用的结合位点序列（30），至少一个编码指示分子（5）的DNA序列（40）和至少 一个最小启动子序列（50），允许所述指示剂分子（5）的基因表达，由此所述干细胞还包括至少一个具有允许其鉴定并具有通过合成DNA序列产生的特征的指示剂分子（5） 40）编码人造引入的DNA分子（6）的指示剂分子（5）。