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    Method and reagent for measuring nitroreductase enzyme activity
    1.
    发明授权
    Method and reagent for measuring nitroreductase enzyme activity 失效
    测定硝基还原酶活性的方法和试剂

    公开(公告)号：US08378120B2

    公开(公告)日：2013-02-19

    申请号：US12500730

    申请日：2009-07-10

    申请人： Richard Martin West ,  Rahman Aziz Ismail

    发明人： Richard Martin West ,  Rahman Aziz Ismail

    IPC分类号： C07D209/02 ,  C07D277/62 ,  C07D263/62

    CPC分类号： C12Q1/26 ,  C09B57/007 ,  C12Q1/32 ,  G01N2500/00

    摘要： Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are of the structure: in which Z1 and Z2 independently represent a phenyl or a naphthyl ring system; X and Y are selected from oxygen, sulphur, —CH═CH— and the group: R1 and R2 are selected from C1-C4 alkyl, —(CH2)n—P, —{(CH2)2—O}p—R6 and group W; where P is selected from COOR7, SO3− and OH, W is mono- or di-substituted nitrobenzyl, R6 is methyl or ethyl, R7 is selected from H, C1-C4 alkyl and CH2OC(O)R8, where R8 is methyl, or t-butyl, n is an integer from 1 to 10, and p is an integer from 1 to 3; R3 and R4 are selected from hydrogen, NO2, halogen, SO3−, C1-C4 alkoxy and —(CH2)m—COOR7; where R7 is hereinbefore defined and m is 0 or an integer from 1 to 5; R5 is C1-C6 alkyl optionally substituted with COOR7, SO3−, or OH; where R7 is hereinbefore defined; and at least one of groups R1, R2, R3 and R4 comprises at least one NO2 group. Also provided are methods for screening for a test agent whose effect upon nitroreductase enzyme activity and nitroreductase gene expression is to be determined.

    摘要翻译： 公开了硝基取代的方酸标记物染料和使用这种染料在细胞测定中检测硝基还原酶活性和硝基还原酶基因表达的方法。 染料具有以下结构：其中Z 1和Z 2独立地表示苯基或萘基环系; X和Y选自氧，硫，-CH = CH-，且R 1和R 2选自C 1 -C 4烷基， - （CH 2）n -P， - {（CH 2）2 -O} p -R 6 和W组; 其中P选自COOR 7，SO 3 - 和OH，W是单取代或二取代的硝基苄基，R 6是甲基或乙基，R 7选自H，C 1 -C 4烷基和CH 2 OC（O）R 8，其中R 8是甲基， 或叔丁基，n为1至10的整数，p为1至3的整数; R3和R4选自氢，NO2，卤素，SO3-，C1-C4烷氧基和 - （CH2）m -COOR7; 其中R7如上定义，m为0或1至5的整数; R5是任选被COOR7，SO3-或OH取代的C1-C6烷基; 其中R7如上定义; 并且R 1，R 2，R 3和R 4中的至少一个包含至少一个NO 2基团。 还提供了筛选对硝基还原酶活性和硝基还原酶基因表达的影响的测试剂的方法。

    TURBO COMPOUND TRANSMISSION AND A METHOD FOR CONTROLLING A TURBO COMPOUND TRANSMISSION
    2.
    发明申请
    TURBO COMPOUND TRANSMISSION AND A METHOD FOR CONTROLLING A TURBO COMPOUND TRANSMISSION 有权
    涡轮复合传输和控制涡轮复合传输的方法

    公开(公告)号：US20130205773A1

    公开(公告)日：2013-08-15

    申请号：US13806148

    申请日：2011-06-22

    申请人： Per Persson ,  Martin West ,  Göran Haraldsson

    发明人： Per Persson ,  Martin West ,  Göran Haraldsson

    IPC分类号： F02B37/00

    CPC分类号： F02B37/00 ,  F01N5/04 ,  F02B39/08 ,  F02B39/16 ,  H02K49/102 ,  H02K49/104 ,  H02K51/00 ,  Y02T10/16 ,  Y02T10/163

    摘要： A turbo compound transmission, such as in a heavy duty or medium duty diesel engine, includes a turbo compound turbine to be driven by exhaust gases from an internal combustion engine, and a coupling including a first rotor including a mechanical input drive adapted to be driven by the turbine, and a second rotor including a mechanical output drive. A brake is arranged to brake and limit the rotation of the turbine. The coupling is arranged to decouple when braking with the brake, subjecting the coupling to a torque above a predetermined torque limit. A method for controlling a turbo compound transmission is also disclosed.

    摘要翻译： 诸如在重型或中型柴油发动机中的涡轮复合式变速器包括由内燃机的排气驱动的涡轮复合涡轮机，以及包括第一转子的联轴器，该第一转子包括适于被驱动的机械输入驱动 以及包括机械输出驱动器的第二转子。 制动器布置成制动并限制涡轮机的旋转。 联接器被布置成当与制动器制动时解耦，使联接器受到高于预定扭矩极限的扭矩。 还公开了一种用于控制涡轮复合传动的方法。

    ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS
    5.
    发明申请
    ACRIDONE DERIVATIVES AS LABELS FOR FLUORESCENCE DETECTION OF TARGET MATERIALS 有权

    公开(公告)号：US20080139788A1

    公开(公告)日：2008-06-12

    申请号：US11943628

    申请日：2007-11-21

    申请人： JOHN ANTHONY SMITH ,  RICHARD MARTIN WEST

    发明人： JOHN ANTHONY SMITH ,  RICHARD MARTIN WEST

    IPC分类号： C07H21/00 ,  C07D401/12 ,  C07D219/00 ,  C07K14/765

    CPC分类号： G01N33/582 ,  C09B15/00

    摘要： Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological assays. The acridone derivatives have the following structure: in which Z1 and Z2 represent the atoms necessary to complete one ring, two fused ring, or three fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; R2, R3, R4 and R5 are selected from hydrogen, halogen, amide, hydroxyl, cyano, nitro, mono- or di-nitro-substituted benzyl, amino, mono- or di-C1-C4 alkyl-substituted amino, sulphydryl, carbonyl, carboxyl, C1-C6 alkoxy, acrylate, vinyl, styryl, aryl, heteroaryl, C1-C20 alkyl, aralkyl, sulphonate, sulphonic acid, quaternary ammonium, the group -E-F and the group —(CH2—)nY; R1 is selected from hydrogen, mono- or di-nitro-substituted benzyl, C1-C20 alkyl, aralkyl, the group -E-F and the group —(CH2—)nY; where E is a spacer group, F is a target bonding group; Y is selected from sulphonate, sulphate, phosphonate, phosphate, quaternary ammonium and carboxyl; and n is an integer from 1 to 6. The invention also relates to a set of different fluorescent acridone dye derivatives, each dye having a different fluorescence lifetime, the set of dyes being particularly useful for multiparameter analysis.

    Alkylation and transalkylation processes using a hydrated catalyst
    6.
    发明授权
    Alkylation and transalkylation processes using a hydrated catalyst 失效
    使用水合催化剂的烷基化和烷基转移方法

    公开(公告)号：US5324877A

    公开(公告)日：1994-06-28

    申请号：US51199

    申请日：1993-04-22

    申请人： Martin West ,  Suheil F. Abdo

    发明人： Martin West ,  Suheil F. Abdo

    IPC分类号： B01J29/18 ,  B01J29/08 ,  C07B61/00 ,  C07C2/66 ,  C07C6/12 ,  C07C15/02 ,  C07C15/073

    CPC分类号： C07C2/66 ,  B01J29/084 ,  C07C6/126 ,  C07C2529/06 ,  C07C2529/08 ,  Y02P20/125 ,  Y02P20/52

    摘要： A composition useful for catalyzing alkylation and transalkylation reactions comprises a molecular sieve having alkylation and/or transalkylation activity, an inorganic refractory oxide component and greater than 3.5 weight percent water. Such a catalyst has been found to maintain a long life when used to produce ethylbenzene in an integrated process in which benzene is alkylated with ethylene and transalkylated with diethylbenzene. The catalyst can also be used to produce cumene via an integrated process in which benzene is alkylated with propylene and transalkylated with diisopropylbenzene.

    摘要翻译： 用于催化烷基化和烷基转移反应的组合物包括具有烷基化和/或烷基转移活性的分子筛，无机难熔氧化物组分和大于3.5重量％的水。 已经发现，这种催化剂在用乙烯烷基化并用二乙基苯烷基化的一体化方法中用于生产乙苯时保持长寿命。 催化剂也可用于通过一种整合方法生产异丙苯，其中苯用丙烯烷基化并用二异丙苯进行烷基化。

    Hydrated alkylation catalyst
    7.
    发明授权
    Hydrated alkylation catalyst 失效
    水解烷基化催化剂

    公开(公告)号：US5240889A

    公开(公告)日：1993-08-31

    申请号：US729458

    申请日：1991-07-12

    申请人： Martin West ,  Suheil F. Abdo

    发明人： Martin West ,  Suheil F. Abdo

    IPC分类号： B01J29/18 ,  B01J29/08 ,  C07B61/00 ,  C07C2/66 ,  C07C6/12 ,  C07C15/02 ,  C07C15/073

    CPC分类号： C07C2/66 ,  B01J29/084 ,  C07C6/126 ,  C07C2529/06 ,  C07C2529/08 ,  Y02P20/125 ,  Y02P20/52

    摘要： A composition useful for catalyzing alkylation and transalkylation reactions comprises a molecular sieve having alkylation and/or transalkylation activity, an inorganic refractory oxide component and greater than 3.5 weight percent water. Such a catalyst has been found to maintain a long life when used to produce ethylbenzene in an integrated process in which benzene is alkylated with ethylene and transalkylated with diethylbenzene. The catalyst can also be used to produce cumene via an integrated process in which benzene is alkylated with propylene and transalkylated with diisopropylbenzene.

    摘要翻译： 用于催化烷基化和烷基转移反应的组合物包括具有烷基化和/或烷基转移活性的分子筛，无机难熔氧化物组分和大于3.5重量％的水。 已经发现，这种催化剂在用乙烯烷基化并用二乙基苯烷基化的一体化方法中用于生产乙苯时保持长寿命。 催化剂也可用于通过一种整合方法生产异丙苯，其中苯用丙烯烷基化并用二异丙苯进行烷基化。

    Alkylation catalyst and processes for preparing
    8.
    发明授权
    Alkylation catalyst and processes for preparing 失效
    烷基化催化剂及其制备方法

    公开(公告)号：US5036033A

    公开(公告)日：1991-07-30

    申请号：US358432

    申请日：1989-05-26

    申请人： Martin West ,  Suheil F. Abdo

    发明人： Martin West ,  Suheil F. Abdo

    IPC分类号： B01J29/08 ,  C07B61/00 ,  C07C2/66 ,  C07C15/073 ,  C07C15/085

    CPC分类号： B01J29/084 ,  C07C2/66 ,  C07C2529/08 ,  Y02P20/52

    摘要： A composition useful for catalyzing alkylation and transalkylation reactions comprises a molecular sieve having alkylation and/or transalkylation activity, an inorganic refractory oxide component and greater than about 250 ppmw ammonium ions, calculated as (NH.sub.4).sub.2 O on a volatiles-free basis. Such a catalyst has been found to be highly selective for the production of cumene in an intergrated process in which benzene is alkylated with propylene and transalkylated with diisopropylbenzene. The catalyst can also be used to selectively produce ethylbenzene via an intergrated process in which benzene is alkylated with ethylene and transalkylated with diethylbenzene.

    摘要翻译： 用于催化烷基化和烷基转移反应的组合物包含具有烷基化和/或烷基转移活性的分子筛，无机难熔氧化物组分和大于约250ppmw的铵离子，以无挥发物计算为（NH 4）2。 已经发现，这种催化剂对于在丙烷中用苯烷基化并用二异丙基苯烷基化的整体方法中生产枯烯是高选择性的。 催化剂也可用于通过其中苯与乙烯烷基化并用二乙基苯烷基化的整合方法选择性地生产乙苯。

    ELECTROMAGNETIC, CONTINUOUSLY VARIABLE TRANSMISSION POWER SPLIT TURBO COMPOUND AND ENGINE AND VEHICLE COMPRISING SUCH A TURBO COMPOUND
    10.
    发明申请
    ELECTROMAGNETIC, CONTINUOUSLY VARIABLE TRANSMISSION POWER SPLIT TURBO COMPOUND AND ENGINE AND VEHICLE COMPRISING SUCH A TURBO COMPOUND 有权
    电磁，连续可变变速箱动力分离涡轮机组合，发动机和包含这种涡轮组合物的车辆

    公开(公告)号：US20120119509A1

    公开(公告)日：2012-05-17

    申请号：US13144697

    申请日：2010-01-12

    申请人： Martin West

    发明人： Martin West

    IPC分类号： H02K7/18 ,  F01D1/02

    CPC分类号： F02B37/00 ,  B60L11/14 ,  B60L2220/50 ,  B60L2220/52 ,  B60Y2400/435 ,  F02B37/004 ,  F02B41/10 ,  H02K16/02 ,  H02K49/06 ,  H02K49/102 ,  H02K51/00 ,  Y02T10/144 ,  Y02T10/163 ,  Y02T10/641 ,  Y02T10/70 ,  Y02T10/7077

    摘要： An electromagnetic, continuously variable transmission power split turbo compound includes a turbo compound turbine driven by exhaust gases from an internal combustion engine, and a power split device comprising a magnetic gear arrangement. The magnetic gear arrangement includes a high speed rotor comprising a first quantity of permanent magnets, a low speed rotor comprising a second quantity of permanent magnets, and a plural pole rotor between the high speed rotor and the low speed rotor. A first rotor of the high speed rotor, the low speed rotor, and the plural pole rotor includes a mechanical input drive adapted to be driven by the turbine. A second rotor of the high speed rotor, the low speed rotor, and the plural pole rotor includes a mechanical output drive. A third rotor of the high speed rotor, the low speed rotor, and the plural pole rotor is unconnected to a mechanical drive and includes a controlling rotor for controlling a ratio of input drive angular velocity to output drive angular velocity.

    摘要翻译： 一种电磁无级变速传动动力分配式涡轮组合体，包括由内燃机排气驱动的涡轮复合涡轮，以及包括磁齿轮装置的动力分配装置。 磁齿轮装置包括包括第一量的永磁体的高速转子，包括第二量的永久磁铁的低速转子和在高速转子和低速转子之间的多极转子。 高速转子，低速转子和多极转子的第一转子包括适于被涡轮驱动的机械输入驱动。 高速转子，低速转子和多极转子的第二转子包括机械输出驱动。 高速转子，低速转子和多极转子的第三转子与机械驱动器不连接，并且包括用于控制输入驱动角速度与输出驱动角速度的比率的控制转子。