Method of racemization of optically active tetrahydrofuran-2-carboxylic
acid
    3.
    发明授权
    Method of racemization of optically active tetrahydrofuran-2-carboxylic acid 失效
    光学活性四氢呋喃-2-羧酸外消旋化的方法

    公开(公告)号:US4950772A

    公开(公告)日:1990-08-21

    申请号:US429425

    申请日:1989-10-31

    IPC分类号: C07D307/24

    CPC分类号: C07D307/24

    摘要: Disclosed is a method of racemization of optically active tetrahydrofuran-2-carboxylic acid. (+)-Tetrahydrofuran-2-carboxylic acid is useful as a side chain intermediate of the antibiotics of penem series, and is prepared by optical resolution of racemic compound. The remaining (+)-isomer should be racemized and reused as the material for further optical resolution. The racemization can be, in accordance with the present invention, carried out by heating the optically active tetrahydrofuran-2-carboxylic acid to a temperature of 100.degree. C. or higher in the presence of a strong base.

    摘要翻译: 公开了光学活性四氢呋喃-2-羧酸外消旋化的方法。 (+) - 四氢呋喃-2-羧酸可用作penem系列抗生素的侧链中间体,并通过旋光拆分外消旋化合物制备。 其余(+) - 异构体应外消旋化并重新用作进一步光学拆分的材料。 根据本发明,外消旋化可以通过在强碱存在下将光学活性四氢呋喃-2-羧酸加热至100℃或更高的温度进行。