公开(公告)号：US20080194034A1

公开(公告)日：2008-08-14

申请号：US11911801

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke ,  Brian D. Sawatzky

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke ,  Brian D. Sawatzky

IPC: G01N35/00 ,  B01J19/00 ,  C12M1/36

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

Abstract translation: 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟急剧缩短，以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。

公开(公告)号：US08034610B2

公开(公告)日：2011-10-11

申请号：US11912273

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

IPC: C12M3/00

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract translation: 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且可以显着缩短滑动处理所需的时间。

公开(公告)号：US08006462B2

公开(公告)日：2011-08-30

申请号：US12683344

申请日：2010-01-06

Applicant: David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

Inventor： David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

IPC: E04H12/18

CPC classification number: B64G1/222 ,  B64G9/00 ,  E04C3/005 ,  E04H12/10 ,  H01Q1/08 ,  H01Q1/1235

Abstract: A deployable truss is formed from a plurality of column members connected at their ends where at least some of the column members are formed from column assemblies, each including a plurality of strut members that are at least connected to each other at a first and second end of the column assembly. For added rigidity, strut members of a column assembly may be connected to each other between the first and second ends using, for example, a rigidizable resin, a fixed spacer, or a deployable spacer. Connecting strut members between the ends of the column assembly provides mutual bracing to the strut members and decreases the free buckling length of the individual strut members. Spacers are preferably configured to radially space the strut members away from the longitudinal centerline of the column assembly to increase its moment of inertia, and hence its buckling strength.

Abstract translation: 可展开的桁架由多个在其端部连接的柱构件形成，其中至少一些柱构件由柱组件形成，每个柱组件包括至少在第一和第二端彼此连接的多个支柱构件 的列组件。 为了增加刚性，柱组件的支柱构件可以使用例如可固化树脂，固定间隔件或可展开间隔件在第一和第二端部彼此连接。 在柱组件的端部之间连接支柱构件为支柱构件提供相互支撑并且减小各个支柱构件的自由弯曲长度。 间隔件优选地构造成将支柱构件径向地定位成远离柱组件的纵向中心线，以增加其转动惯量，并因此增加其屈曲强度。

公开(公告)号：US08178350B2

公开(公告)日：2012-05-15

申请号：US11911801

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Brian D. Sawatzky ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Brian D. Sawatzky ,  Matthew M. Botke

IPC: G01N35/00

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A method of biochemical processing may, in certain embodiments, involve the steps of use of a consumable biochemical process element and a consumable biochemical process alterable information memory element associated therewith, such as a substance withdrawal consumable biochemical process alterable information memory element, that may be queried and at least some of whose information may be changed as a result of actions conducted during processing of a biochemical test sequence. Accordingly, advantages relative to knowing how much of a consumable biochemical process element has been used, and how much may be available during a biochemical test sequence, may be achieved.

Abstract translation: 在某些实施方案中，生物化学处理的方法可以包括使用消耗性生物化学过程元件和与其相关联的消耗性生物化学过程可变信息存储元件的步骤，例如物质提取消耗性生物化学过程可变信息存储元件，其可以是 查询，并且至少其中一些信息可能由于在生化测试序列的处理期间进行的动作而改变。 因此，可以实现相对于知道消耗性生物化学过程元素已经被使用多少的优点，以及在生物化学测试序列期间可获得多少的优点。

公开(公告)号：US20100101172A1

公开(公告)日：2010-04-29

申请号：US12683344

申请日：2010-01-06

Applicant: David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

Inventor： David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

IPC: E04H12/18 ,  E04H12/10 ,  E04B1/58

CPC classification number: B64G1/222 ,  B64G9/00 ,  E04C3/005 ,  E04H12/10 ,  H01Q1/08 ,  H01Q1/1235

Abstract: A deployable truss is formed from a plurality of column members connected at their ends where at least some of the column members are formed from column assemblies, each including a plurality of strut members that are at least connected to each other at a first and second end of the column assembly. For added rigidity, strut members of a column assembly may be connected to each other between the first and second ends using, for example, a rigidizable resin, a fixed spacer, or a deployable spacer. Connecting strut members between the ends of the column assembly provides mutual bracing to the strut members and decreases the free buckling length of the individual strut members. Spacers are preferably configured to radially space the strut members away from the longitudinal centerline of the column assembly to increase its moment of inertia, and hence its buckling strength.

Abstract translation: 可展开的桁架由多个在其端部连接的柱构件形成，其中至少一些柱构件由柱组件形成，每个柱组件包括至少在第一和第二端彼此连接的多个支柱构件 的列组件。 为了增加刚性，柱组件的支柱构件可以使用例如可固化树脂，固定间隔件或可展开间隔件在第一和第二端部彼此连接。 在柱组件的端部之间连接支柱构件为支柱构件提供相互支撑并且减小各个支柱构件的自由弯曲长度。 间隔件优选地构造成将支柱构件径向地定位成远离柱组件的纵向中心线，以增加其转动惯量，并因此增加其屈曲强度。

公开(公告)号：US07838283B2

公开(公告)日：2010-11-23

申请号：US11912095

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

IPC: C12M1/34

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.

Abstract translation: 可以被配置为在诸如组织化学处理的适当处理顺序结束时实现物质的自动抽出的样品处理系统可以包括多个样品，通过移动可以在辊上具有顺序的先进吸收材料的芯吸筒去除物质 其基于诸如重复消除和重新应用流体物质的顺序进行适当的量，可能通过毛细血管运动的作用，以便刷新与诸如活组织检查或其它样品的样品相邻的微环境。 可以包括吸入芯片，也可能包含抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。

公开(公告)号：US07694486B2

公开(公告)日：2010-04-13

申请号：US10734726

申请日：2003-12-12

Applicant: David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

Inventor： David M. Murphy ,  Thomas W. Murphey ,  Michael E. McEachen ,  Matthew M. Botke

IPC: E04H12/18

CPC classification number: B64G1/222 ,  B64G9/00 ,  E04C3/005 ,  E04H12/10 ,  H01Q1/08 ,  H01Q1/1235

Abstract: A deployable truss is formed from a plurality of column members connected at their ends where at least some of the column members are formed from column assemblies, each including a plurality of strut members that are at least connected to each other at a first and second end of the column assembly. For added rigidity, strut members of a column assembly may be connected to each other between the first and second ends using, for example, a rigidizable resin, a fixed spacer, or a deployable spacer. Connecting strut members between the ends of the column assembly provides mutual bracing to the strut members and decreases the free buckling length of the individual strut members. Spacers are preferably configured to radially space the strut members away from the longitudinal centerline of the column assembly to increase its moment of inertia, and hence its buckling strength.

Abstract translation: 可展开的桁架由多个在其端部连接的柱构件形成，其中至少一些柱构件由柱组件形成，每个柱组件包括至少在第一和第二端彼此连接的多个支柱构件 的列组件。 为了增加刚性，柱组件的支柱构件可以使用例如可固化树脂，固定间隔件或可展开间隔件在第一和第二端部彼此连接。 在柱组件的端部之间连接支柱构件为支柱构件提供相互支撑并且减小各个支柱构件的自由弯曲长度。 间隔件优选地构造成将支柱构件径向地定位成远离柱组件的纵向中心线，以增加其转动惯量，并因此增加其屈曲强度。

公开(公告)号：US20080213804A1

公开(公告)日：2008-09-04

申请号：US11912273

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

IPC: G01N33/574 ,  G01N33/53

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

Abstract translation: 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟急剧缩短，以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。

公开(公告)号：US08058010B2

公开(公告)日：2011-11-15

申请号：US11911946

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

IPC: G01N33/53

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.

Abstract translation: 可以被配置为实现快速样品处理（例如快速组织化学处理）的样品处理系统可以涉及可以使用角度微观滑动运动引起重复消除和重新应用流体物质的波浪元件，这可能是通过毛细管运动的作用，以便 刷新与诸如活组织检查或其他样品的样品相邻的微环境。 通过微环境的清新，避免了微环境的消耗，并且可以显着缩短滑动处理所需的时间。

公开(公告)号：US20090004691A1

公开(公告)日：2009-01-01

申请号：US11911946

申请日：2006-04-21

Applicant: Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

Inventor： Page A. Erickson ,  Michael R. Everman ,  Michael S. Bell ,  Kevin S. Edberg ,  Matthew M. Botke

IPC: G01N33/50 ,  C12M3/00 ,  G01N1/20

CPC classification number: G01N35/00029 ,  G01N1/312 ,  G01N35/00009 ,  G01N2035/00039 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/113332

Abstract: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minute to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.

Abstract translation: 可以被配置为实现快速样品处理（例如快速组织化学处理）的样品处理系统可以涉及可以使用角度微观滑动运动引起重复消除和重新应用流体物质的波浪元件，这可能是通过毛细管运动的作用，以便 刷新与诸如活组织检查或其他样品的样品相邻的微环境。 通过微环境的清新，避免了微环境的消耗，并且幻灯片处理所需的时间可以从更常见的60到120分钟到可能小于15分钟被显着地缩短，以便允许在术中使用这样的系统 或手术环境，例如美国病理学家学院术中指南等推荐的。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。