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公开(公告)号：US08178350B2
公开(公告)日：2012-05-15
申请号：US11911801
申请日：2006-04-21
申请人： Page A. Erickson , Michael R. Everman , Michael S. Bell , Kevin S. Edberg , Brian D. Sawatzky , Matthew M. Botke
发明人： Page A. Erickson , Michael R. Everman , Michael S. Bell , Kevin S. Edberg , Brian D. Sawatzky , Matthew M. Botke
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A method of biochemical processing may, in certain embodiments, involve the steps of use of a consumable biochemical process element and a consumable biochemical process alterable information memory element associated therewith, such as a substance withdrawal consumable biochemical process alterable information memory element, that may be queried and at least some of whose information may be changed as a result of actions conducted during processing of a biochemical test sequence. Accordingly, advantages relative to knowing how much of a consumable biochemical process element has been used, and how much may be available during a biochemical test sequence, may be achieved.
摘要翻译： 在某些实施方案中，生物化学处理的方法可以包括使用消耗性生物化学过程元件和与其相关联的消耗性生物化学过程可变信息存储元件的步骤，例如物质提取消耗性生物化学过程可变信息存储元件，其可以是 查询，并且至少其中一些信息可能由于在生化测试序列的处理期间进行的动作而改变。 因此，可以实现相对于知道消耗性生物化学过程元素已经被使用多少的优点，以及在生物化学测试序列期间可获得多少的优点。
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公开(公告)号：US20080194034A1
公开(公告)日：2008-08-14
申请号：US11911801
申请日：2006-04-21
申请人： Page A. Erickson , Michael R. Everman , Michael S. Bell , Kevin S. Edberg , Matthew M. Botke , Brian D. Sawatzky
发明人： Page A. Erickson , Michael R. Everman , Michael S. Bell , Kevin S. Edberg , Matthew M. Botke , Brian D. Sawatzky
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
摘要翻译： 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟急剧缩短，以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。
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3.发明授权Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry 有权用于自动化快速免疫组织化学的并行处理流体学方法和装置公开(公告)号：US08034610B2
公开(公告)日：2011-10-11
申请号：US11912273
申请日：2006-04-21
IPC分类号： C12M3/00
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.
摘要翻译： 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且可以显着缩短滑动处理所需的时间。
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4.发明授权Wicking cassette method and apparatus for automated rapid immunohistochemistry 有权用于自动快速免疫组化的芯吸盒方法和装置公开(公告)号：US07838283B2
公开(公告)日：2010-11-23
申请号：US11912095
申请日：2006-04-21
IPC分类号： C12M1/34
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.
摘要翻译： 可以被配置为在诸如组织化学处理的适当处理顺序结束时实现物质的自动抽出的样品处理系统可以包括多个样品，通过移动可以在辊上具有顺序的先进吸收材料的芯吸筒去除物质 其基于诸如重复消除和重新应用流体物质的顺序进行适当的量，可能通过毛细血管运动的作用，以便刷新与诸如活组织检查或其它样品的样品相邻的微环境。 可以包括吸入芯片，也可能包含抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。
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5.发明申请Parallel Processing Fluidic Method and Apparatus for Automated Rapid Immunohistochemistry 有权用于自动快速免疫组化的平行加工流体方法和装置公开(公告)号：US20080213804A1
公开(公告)日：2008-09-04
申请号：US11912273
申请日：2006-04-21
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges. Through refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minutes to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
摘要翻译： 可以被配置为实现平行或重复的样品处理（例如组织化学处理）的样品处理系统可以涉及可以通过使用角度显微镜幻灯片移动来布置为巧合运动的多个样品，以引起处理活动，所述处理活动可以包括反复消除和重新应用 流体物质可能通过毛细管运动的作用，以便刷新邻近样品的微环境，例如活组织检查或其它这样的样品。 可以包括抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。 通过刷新微环境，避免了微环境的消耗，并且幻灯片处理所需的时间可能会从更常见的60到120分钟到可能少于15分钟急剧缩短，以便允许在术中或术中使用这样的系统 手术环境如美国病理学家推荐的术中指南等。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。
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6.发明授权Enhanced fluidic method and apparatus for automated rapid immunohistochemistry 有权用于自动化快速免疫组化的增强流体学方法和装置公开(公告)号：US08058010B2
公开(公告)日：2011-11-15
申请号：US11911946
申请日：2006-04-21
IPC分类号： G01N33/53
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened.
摘要翻译： 可以被配置为实现快速样品处理（例如快速组织化学处理）的样品处理系统可以涉及可以使用角度微观滑动运动引起重复消除和重新应用流体物质的波浪元件，这可能是通过毛细管运动的作用，以便 刷新与诸如活组织检查或其他样品的样品相邻的微环境。 通过微环境的清新，避免了微环境的消耗，并且可以显着缩短滑动处理所需的时间。
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7.发明申请Enhanced Fluidic Method and Apparatus for Automated Rapid Immunohistochemistry 有权用于自动快速免疫组织化学的增强流体学方法和装置公开(公告)号：US20090004691A1
公开(公告)日：2009-01-01
申请号：US11911946
申请日：2006-04-21
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Through such refreshing of a microenvironment, depletion of the microenvironment is avoided and the time necessary for slide processing may be dramatically shortened from a more common 60 to 120 minute to perhaps less than 15 minutes so as to permit use of such a system in an intraoperative or surgical environment such as recommended by the College of American Pathologists intraoperative guidelines or the like. Patients may thus avoid a need to be subjected to an additional surgical procedure when lab results become available to see if tumors or the like were fully removed in a prior procedure.
摘要翻译： 可以被配置为实现快速样品处理（例如快速组织化学处理）的样品处理系统可以涉及可以使用角度微观滑动运动引起重复消除和重新应用流体物质的波浪元件，这可能是通过毛细管运动的作用，以便 刷新与诸如活组织检查或其他样品的样品相邻的微环境。 通过微环境的清新，避免了微环境的消耗，并且幻灯片处理所需的时间可以从更常见的60到120分钟到可能小于15分钟被显着地缩短，以便允许在术中使用这样的系统 或手术环境，例如美国病理学家学院术中指南等推荐的。 因此，当实验室结果变得可用时，患者可能避免需要进行额外的外科手术，以便在先前的手术中是否完全移除肿瘤等。
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8.发明申请Wicking Cassette Method and Apparatus for Automated Rapid Immunohistochemistry 有权用于自动快速免疫组化的芯吸盒方法和装置公开(公告)号：US20080286753A1
公开(公告)日：2008-11-20
申请号：US11912095
申请日：2006-04-21
CPC分类号： G01N35/00029 , G01N1/312 , G01N35/00009 , G01N2035/00039 , Y10T436/11 , Y10T436/112499 , Y10T436/113332
摘要： A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls that are advanced an appropriate amount based upon usage in sequences such as repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to refresh a microenvironment adjacent to a sample such as a biopsy or other such sample. Snap in wicking cassettes and perhaps antibody and other substances may be included to ease operator actions and to permit location specific substance applications perhaps by including single container multiple chamber multiple fluidic substance magazines, linearly disposed multiple substance source, and primary antibody cartridges.
摘要翻译： 可以被配置为在诸如组织化学处理的适当处理顺序结束时实现物质的自动抽出的样品处理系统可以包括多个样品，通过移动可以在辊上具有顺序的先进吸收材料的芯吸筒去除物质 其基于诸如重复消除和重新应用流体物质的顺序进行适当的量，可能通过毛细血管运动的作用，以便刷新与诸如活组织检查或其它样品的样品相邻的微环境。 可以包括吸入芯片，也可能包含抗体和其他物质，以减轻操作者的行为，并允许通过包括单容器多腔多重流体物质杂志，线性放置的多物质源和一级抗体盒来允许位置特异性物质应用。
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公开(公告)号：US5930461A
公开(公告)日：1999-07-27
申请号：US941507
申请日：1997-09-30
CPC分类号： G01N1/312 , B25J9/1671 , B25J9/1679 , G01N35/0099 , G05B2219/45092
摘要： A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which may move the different tissue samples among a plurality of processing stations, and a processor, which may select the next tissue sample to move, when to move it, and where to move it to. The processor may direct the robotic arm to interleave the differing process steps. The processor may select a tissue sample to be moved in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may comprise a graphic interface by which an operator may specify the steps of a procedure. A display of grid locations may comprise symbols for the workstations, which an operator may identify with a pointing device such as a mouse. The operator may create a list of process steps for a procedure by selecting a sequence of workstations with the mouse, and associating timing or other information for each process step with the selected workstation. The operator may also choose to select a list of stored process steps for a procedure.
摘要翻译： 一种同时进行多个独立分析程序的系统，可能涉及不同类型的组织和不同的处理步骤，包括可以移动多个处理站中的不同组织样本的机器人手臂和可以选择 下一个组织样本移动，何时移动，以及移动到哪里。 处理器可引导机器臂来交织不同的处理步骤。 处理器可以响应于关于过程的定时信息来选择要移动的组织样本，其可以指定每个处理步骤的开始时间和结束时间。 指定的时间可能是精确的或可能是一个时间范围。 处理器可以通过生成可能的步骤序列并检查该冲突序列来确定步骤的确切时间，并且响应于具有指定时间范围的那些步骤来调整该序列，并且迭代多个可能序列的计算。 处理器可以包括图形界面，操作者可以通过图形界面指定过程的步骤。 网格位置的显示可以包括用于工作站的符号，操作员可以用诸如鼠标的指示设备来识别。 操作员可以通过使用鼠标选择一系列工作站，并将每个处理步骤的定时或其他信息与所选择的工作站相关联，来创建过程的过程步骤列表。 操作员还可以选择为过程选择存储的处理步骤的列表。
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公开(公告)号：US5875286A
公开(公告)日：1999-02-23
申请号：US985604
申请日：1997-12-05
CPC分类号： B25J9/1679 , B25J9/1671 , G01N1/312 , G01N35/0092 , G01N35/0099 , G01N2035/0093 , G01N2035/1093 , G05B2219/40097 , G05B2219/40098 , G05B2219/40099 , G05B2219/40108 , G05B2219/40113 , G05B2219/40463 , G05B2219/45092 , G05B2219/45118 , Y10T436/11 , Y10T436/115831
摘要： A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic arm, which moves the different tissue samples among a plurality of processing stations, and a processor, which selects the next tissue sample to move, when to move it, and where to move it to. The processor directs the robotic arm to interleave the differing process steps. The processing stations comprise workstations for performing individual steps of the tissue assay procedures, such as solution trays. The processor selects a tissue sample to be moved in response to timing information about the procedures. While the processor is directing the robotic arm to move, the processor monitors progress information and can alter the sequence of process steps in response to the progress information and information from an operator.
摘要翻译： 同时执行多个独立分析程序的系统，可能涉及不同类型的组织和不同的处理步骤，包括移动多个处理站中的不同组织样本的机器人手臂和选择下一个组织的处理器 样品移动，何时移动，以及将其移动到哪里。 处理器指示机器人手臂来交织不同的处理步骤。 处理站包括用于执行组织测定程序的各个步骤的工作站，例如溶液托盘。 响应于关于过程的定时信息，处理器选择要移动的组织样本。 当处理器指示机器人手臂移动时，处理器监视进度信息，并且可以响应于来自操作者的进度信息和信息来改变处理步骤的顺序。
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