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公开(公告)号：US09678222B2
公开(公告)日：2017-06-13
申请号：US12594958
申请日：2008-04-08
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/20
摘要： A radiation detector device for detecting a primary radiation includes a scintillator which generates a converted primary radiation in response to incoming primary radiation and a photo detector for detecting the converted primary radiation. The radiation detector device further includes a secondary radiation source for irradiating the scintillator with a secondary radiation which has a wavelength different from a wavelength of the first radiation and which is capable of producing a spatially more uniform response of the scintillator to primary radiation.
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2.发明申请REDUCING TRAP EFFECTS IN A SCINTILLATOR BY APPLICATION OF SECONDARY RADIATION 有权通过应用二次辐射降低扫描仪中的陷阱效应公开(公告)号：US20100140484A1
公开(公告)日：2010-06-10
申请号：US12594958
申请日：2008-04-08
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/20
摘要： According to an embodiment of the invention, a radiation detector device (10) for detecting a primary radiation (6) comprises a scintillator (12) which generates a converted primary radiation in response to incoming primary radiation (6) and a photo detector (14) for detecting the converted primary radiation. The radiation detector device (10) further comprises a secondary radiation source (20) for irradiating the scintillator (12) with a secondary radiation (22) which has a wavelength different from a wavelength of the first radiation (6) and which is capable of producing a spatially more uniform response of the scintillator (12) to primary radiation. In an embodiment of the invention, the radiation detector device (10) is an X-ray detector of an X-ray imaging apparatus where the primary radiation is X-ray radiation and the secondary radiation has a wavelength between 350 nm and 450 nm. According to an embodiment, the irradiation with the secondary radiation, e.g. UV radiation, produces a uniform gain distribution of the X-ray detector (10).
摘要翻译： 根据本发明的实施例，用于检测初级辐射（6）的辐射检测器装置（10）包括闪烁体（12），其响应于入射的主辐射（6）和光检测器（14）产生转换的一次辐射 ）用于检测转换的一次辐射。 辐射检测器装置（10）还包括用于用闪光体（12）照射具有与第一辐射（6）的波长不同的波长的次辐射（22）的次辐射源（20） 产生闪烁体（12）对初级辐射的空间上更均匀的响应。 在本发明的一个实施例中，辐射检测器装置（10）是X射线成像装置的X射线检测器，其中初级辐射是X射线辐射，二次辐射具有在350nm与450nm之间的波长。 根据一个实施例，用二次辐射的照射，例如， UV辐射，产生X射线检测器（10）的均匀增益分布。
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公开(公告)号：US20100051816A1
公开(公告)日：2010-03-04
申请号：US12594959
申请日：2008-04-09
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/2928
摘要： A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-rayimaging device where the primary radiation is X-rayradiation, the invention provides for an accurate calibration of the X-raydetector without irradiating the X-raydetector with X-rayradiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.
摘要翻译： 提供了一种用于提供关于主辐射的闪烁体的空间增益分布的信息的方法，其不需要用初级辐射照射闪烁体。 该方法包括用二次辐射照射闪烁体的步骤，用于产生用于所述第二辐射的闪烁体的空间二次增益分布的图像。 空间二次增益分布图像对应于初级辐射的空间初级增益分布的图像。 在本发明的一个实施例中，即在主辐射为X射线照射的X射线成像装置中，本发明提供了X射线检测器的精确校准，而不用X射线照射X射线检测器。 相反，用UV辐射作为辅助辐射的照射提供了可用于校准的期望的空间二次增益分布图像。
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公开(公告)号：US08138481B2
公开(公告)日：2012-03-20
申请号：US12594959
申请日：2008-04-09
IPC分类号： G01T1/10
CPC分类号： G01T1/2018 , G01T1/2928
摘要： A method for providing information about a spatial gain distribution of a scintillator for a primary radiation is provided which does not require the irradiation of the scintillator with the primary radiation. The method comprises the step of irradiating the scintillator with a secondary radiation for generating an image of a spatial secondary gain distribution of the scintillator for said second radiation. The spatial secondary gain distribution image corresponds to an image of the spatial primary gain distribution for the primary radiation. In an embodiment of the invention, i.e. in an X-ray imaging device where the primary radiation is X-ray radiation, the invention provides for an accurate calibration of the X-ray detector without irradiating the X-ray detector with X-ray radiation. Rather, irradiation with UV radiation as the secondary radiation provides the desired spatial secondary gain distribution image which can be used for calibration.
摘要翻译： 提供了一种用于提供关于主辐射的闪烁体的空间增益分布的信息的方法，其不需要用初级辐射照射闪烁体。 该方法包括用二次辐射照射闪烁体的步骤，用于产生用于所述第二辐射的闪烁体的空间二次增益分布的图像。 空间二次增益分布图像对应于初级辐射的空间初级增益分布的图像。 在本发明的一个实施例中，即在主要辐射是X射线辐射的X射线成像装置中，本发明提供了对X射线检测器的精确校准，而不用X射线辐射照射X射线检测器 。 相反，用UV辐射作为辅助辐射的照射提供了可用于校准的期望的空间二次增益分布图像。
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公开(公告)号：US08775852B2
公开(公告)日：2014-07-08
申请号：US13303301
申请日：2011-11-23
申请人： Holger Röhle , Matthias Simon
发明人： Holger Röhle , Matthias Simon
CPC分类号： G05B19/054 , G05B19/0423
摘要： A method for sensing input signal changes at an input of an input/output module operated in an automation system in which a signal is sampled by an input/output module. A change event and a timestamp associated with the change event are generated when a change in the sampled signal occurs and a value pair comprising the change event and the timestamp is stored in a higher-ranking automation component to the input/output module. The input/output module and the higher-ranking automation component are operated clock-synchronously with respect to one another by a clock pulse, and the timestamp is calculated centrally on the higher-ranking automation component based on the clock-synchronous operation.
摘要翻译： 一种用于在其中信号由输入/输出模块采样的自动化系统中操作的输入/输出模块的输入处感测输入信号变化的方法。 当发生采样信号的改变并且包括改变事件和时间戳的值对存储在输入/输出模块的较高级别的自动化组件中时，生成与改变事件相关联的改变事件和时间戳。 输入/输出模块和较高级别的自动化组件通过时钟脉冲相对于彼此进行时钟同步操作，并且基于时钟同步操作在较高级别的自动化组件上集中计算时间戳。
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公开(公告)号：US20110211668A1
公开(公告)日：2011-09-01
申请号：US13127769
申请日：2009-11-09
申请人： Roger Steadman Booker , Matthias Simon , Christoph Herrmann , Bernd Menser , Jens Wiegert , Klaus Juergen Engel , Christian Baeumer , Oliver Muelhens
发明人： Roger Steadman Booker , Matthias Simon , Christoph Herrmann , Bernd Menser , Jens Wiegert , Klaus Juergen Engel , Christian Baeumer , Oliver Muelhens
CPC分类号： G01T1/249 , G01T1/24 , G01T1/2928
摘要： The invention relates to converter element (100) for a radiation detector, particularly for a Spectral CT scanner. The converter element (100) comprises at least two conversion cells (131) that are at least partially separated from each other by intermediate separation walls (135) which affect the spreading of electrical signals generated by incident radiation (X). The conversion cells (131) may particularly consist of a crystal of CdTe and/or CdZnTe. Said crystal is preferably grown by e.g. vapor deposition between preformed separation walls.
摘要翻译： 本发明涉及用于辐射检测器的转换器元件（100），特别是用于光谱CT扫描仪。 转换器元件（100）包括至少两个转换单元（131），所述至少两个转换单元（131）通过影响由入射辐射（X）产生的电信号的扩展的中间分隔壁（135）至少部分地彼此分离。 转换电池（131）可以特别地由CdTe和/或CdZnTe的晶体组成。 所述晶体优选通过例如 预成型分隔壁之间的气相沉积。
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公开(公告)号：US20060239407A1
公开(公告)日：2006-10-26
申请号：US10558722
申请日：2004-05-26
IPC分类号： H05G1/64
CPC分类号： H04N5/3597 , H04N5/325
摘要： The invention relates to a detector and a method for the production of consecutive X-ray images. This involves the generation in the detector by X-radiation during an exposure interval (Texp) of a current flow (I(t)) which is integrated (Qdk*, Qsig*, Qae*) in a memory capacity and read out in a subsequent readout phase (Trd). In order to minimize the influence of slowly decaying residual currents (Iae), the current (I(t)) is integrated only during the exposure interval (Texp). By this means, disturbing artifacts due to residual signals from earlier photographs are minimized.
摘要翻译： 本发明涉及用于生产连续X射线图像的检测器和方法。 这涉及在积分的电流（I（t））的曝光间隔（T（t））期间，通过X射线在检测器中产生检测器（Q ，存储器容量，并在随后的读出阶段（T ）中读出。 为了最小化缓慢衰减的剩余电流的影响，电流（I（t））仅在曝光间隔（T ）期间被积分。 通过这种方式，由于来自较早照片的残留信号引起的干扰赝像被最小化。
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公开(公告)号：US20050242270A1
公开(公告)日：2005-11-03
申请号：US10525472
申请日：2003-08-14
申请人： Michael Overdick , Matthias Simon
发明人： Michael Overdick , Matthias Simon
摘要： The invention relates to a detector arrangement for the conversion of electromagnetic radiation into electrical signals. The detector arrangement includes sensitive areas (D1, D2, D3, D4), where each sensitive area corresponds to a respective electrical signal, and at least two of the sensitive areas mesh with one another in such a manner that non-overlapping envelopes (C1, C2, C3, C4) of the individual meshing sensitive areas also mesh with one another.
摘要翻译： 本发明涉及一种用于将电磁辐射转换成电信号的检测器装置。 检测器装置包括敏感区域（D 1，D 2，D 3，D 4），其中每个敏感区域对应于相应的电信号，并且至少两个敏感区域彼此啮合， 各个啮合敏感区域的重叠信封（C 1，C 2，C 3，C 4）也彼此啮合。
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公开(公告)号：US09573960B2
公开(公告)日：2017-02-21
申请号：US14126512
申请日：2012-06-15
申请人： Björn Scheffler , Martin Glas , Matthias Simon , Sabine Gogolok , Daniel Trageser , Roman Reinartz , Anja Wieland
发明人： Björn Scheffler , Martin Glas , Matthias Simon , Sabine Gogolok , Daniel Trageser , Roman Reinartz , Anja Wieland
IPC分类号： C07D493/06 , C07D493/18 , A61K31/352 , G01N33/574 , A61K31/4188
CPC分类号： C07D493/18 , A61K31/352 , A61K31/4188 , C07D493/06 , G01N33/57492 , G01N2333/70596 , G01N2800/52
摘要： The present invention relates to glioblastoma inhibiting compounds, in particular gambogic acid amid and derivatives thereof for the treatment of glioblastoma. Moreover, methods for determining whether a treatment with the compounds of the invention is suitable for a patient are disclosed.
摘要翻译： 本发明涉及成胶质细胞瘤抑制化合物，特别是用于治疗胶质母细胞瘤的葡萄糖酸及其衍生物。 此外，公开了用于确定用本发明的化合物治疗是否适合于患者的方法。
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公开(公告)号：US09103819B2
公开(公告)日：2015-08-11
申请号：US12867442
申请日：2009-09-09
IPC分类号： G01N33/574 , C12N5/09 , G01N33/50 , C12N5/079 , A61P35/00
CPC分类号： G01N33/5011 , C12N5/0618 , C12N5/0622 , C12N5/0693 , G01N33/5017 , G01N33/502 , G01N33/5058 , G01N33/574 , G01N2333/705 , G01N2333/70596 , G01N2500/10
摘要： The present invention relates to a tumor cell of the peripheral zone of a tumor and methods of providing such a tumor cell. Further provided is a method for identifying a molecular marker diagnostic for an infiltrative cancer, an antibody, which specifically binds to such molecular marker, a method for identifying a therapeutic compound effective against a metastatic/infiltrative cancer disease and the use of a tumor cell according to the invention.
摘要翻译： 本发明涉及肿瘤周边区域的肿瘤细胞和提供这种肿瘤细胞的方法。 进一步提供一种用于鉴定渗透性癌症的分子标记物的诊断方法，特异性结合该分子标记物的抗体，鉴定对转移性/浸润性癌症有效的治疗化合物的方法以及肿瘤细胞的用途 涉及本发明。
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