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    Brachytherapy catheter system
    2.
    发明授权
    Brachytherapy catheter system 失效
    近距离放射治疗导管系统

    公开(公告)号：US5916143A

    公开(公告)日：1999-06-29

    申请号：US748698

    申请日：1996-11-13

    申请人： Marc G. Apple ,  Melvin J. Apple

    发明人： Marc G. Apple ,  Melvin J. Apple

    IPC分类号： A61M25/00 ,  A61B17/22 ,  A61F2/958 ,  A61M36/04 ,  A61N5/10 ,  A61N5/00

    CPC分类号： A61M25/1002 ,  A61N5/1002 ,  A61B2017/22068 ,  A61M2025/1047 ,  A61N2005/1021

    摘要： A system, apparatus, and method for administering radiation internal to a patient involving a catheter, having disposed therewithin a radiation carrier material such as an inert radioactive gas, like xenon, for the treatment of restenosis after angioplasty, and malignancies. When the catheter apparatus is inflated, it may include a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation.

    摘要翻译： 用于对涉及导管的患者内部施加辐射的系统，装置和方法，所述导管在辐射载体材料如惰性放射性气体（例如氙）中设置，用于治疗血管成形术后的再狭窄和恶性肿瘤。 当导管装置膨胀时，其可以包括用于输送放射性载体材料的多个分立的腔室和多个分立的腔室，其在用规定的辐射治疗期间能够使动脉能够显着地流过动脉。

    Directional-ionizing energy emitting implant
    3.
    发明授权
    Directional-ionizing energy emitting implant 有权
    定向电离能量发射植入物

    公开(公告)号：US07029431B2

    公开(公告)日：2006-04-18

    申请号：US10421032

    申请日：2003-04-24

    申请人： Melvin J. Apple ,  Marc G. Apple

    发明人： Melvin J. Apple ,  Marc G. Apple

    IPC分类号： A61N5/00

    CPC分类号： A61B17/68 ,  A61B17/8066 ,  A61F2/32 ,  A61F2/38 ,  A61F2002/30082 ,  A61F2002/30299 ,  A61F2002/30878 ,  A61F2002/30932 ,  A61F2210/0095 ,  A61F2230/0093 ,  A61K51/1282 ,  A61N5/1001 ,  A61N2005/1019

    摘要： The directional-ionizing energy emitting implant is for attachment either to natural tissue or a prosthetic device, and delivers a prescribed dosage of energy to targeted tissue. The insert device includes an energy-source material within the insert device that delivers the prescribed dosage of energy to the targeted tissue, while minimizing exposure of nontargeted tissue. The targeted tissue has a known energy-response profile and is adjacent to the targeted tissue. The energy-source material in combination with the prosthetic device defines an actual energy-delivery distribution field. The energy-delivery distribution field has a configuration similar to the known energy-responsive profile of the targeted tissue. The prescribed dosage of energy is applied from energy-source material within the insert device and directed to the targeted tissue. The prescribed energy dosage is determined by using known characteristics of the energy-source material, and by the placement of the energy-source material relative to the targeted tissue. The implant system reduces any occurrence of heterotopic ossification caused by the implant, inhibits growth or migration of benign or malignant living cells, and minimizes or even eliminates infectious processes or delayed keloid or scar formation induced from surgical placement of a functional prosthesis or fixation device, in tissue within or about the device due to its targeted therapeutic energy emission effects.

    摘要翻译： 定向电离能量发射植入物用于附着到天然组织或假体装置，并将规定剂量的能量递送至靶组织。 插入装置包括在插入装置内的能量源材料，其将预定剂量的能量递送到目标组织，同时使非靶向组织的暴露最小化。 目标组织具有已知的能量响应曲线并且与目标组织相邻。 能量源材料与假体装置组合定义了实际的能量输送分布场。 能量输送分布场具有与目标组织的已知能量响应曲线相似的构造。 规定剂量的能量从插入装置内的能源材料施加并且被引导到目标组织。 通过使用能源材料的已知特征以及相对于目标组织放置能源材料来确定规定的能量剂量。 植入物系统减少由植入物引起的异位骨化的任何发生，抑制良性或恶性活细胞的生长或迁移，并且最小化甚至消除由功能性假体或固定装置的手术放置引起的感染过程或延迟的瘢痕疙瘩或瘢痕形成， 由于其靶向的治疗能量发射效应，在装置内或周围的组织中。

    Catheter system
    4.
    发明授权
    Catheter system 失效
    导管系统

    公开(公告)号：US06117064A

    公开(公告)日：2000-09-12

    申请号：US3383

    申请日：1998-01-06

    申请人： Marc G. Apple ,  Melvin J. Apple

    发明人： Marc G. Apple ,  Melvin J. Apple

    IPC分类号： A61B17/22 ,  A61F2/958 ,  A61M36/06 ,  A61N5/10 ,  A61N5/00 ,  A61M3/00 ,  A61M29/00

    CPC分类号： A61M25/1002 ,  A61N5/1002 ,  A61B2017/22068 ,  A61M2025/1047

    摘要： A catheter apparatus filled with a radiation carrier material such as an inert radioactive gas for the treatment of restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter may also comprise one unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. In addition, two opposing balloons may be utilized that are inflatable in sequence enabling gas-tight redirection of radioactive gas flow from one balloon to the other, where one balloon is inflated to deliver a treatment dose, while the opposing balloon is deflated.

    摘要翻译： 填充有诸如惰性放射性气体的辐射载体材料用于治疗血管成形术后的再狭窄的导管装置和恶性肿瘤。 充气导管包括用于输送放射性载体材料的多个离散室，以及多个分立的腔室，其能够在用规定的辐射治疗期间使血液能够显着地流过动脉。 充气导管还可以包括一个单位气囊。 特定的金属涂层增强了传递给靶的辐射剂量。 腔的壁衰减通过导管装置的中空内腔循环的血液的传播剂量。 该系统还产生增加的副产物辐射，从β粒子和γ质子向腔壁行进的影响。 此外，可以使用两个相对的气囊，其可依次充气，使得放射性气体气流能够气密地重定向从一个气囊到另一个气囊，其中一个气囊被充气以递送治疗剂量，同时相对的气囊被放气。