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1.发明申请PURIFYING INSULIN USING CATION EXCHANGE AND REVERSE PHASE CHROMATOGRAPHY IN THE PRESENCE OF AN ORGANIC MODIFIER AND ELEVATED TEMPERATURE 审中-公开在有机改性剂和高温下存在时，使用阴离子交换和反相色谱法净化胰岛素公开(公告)号：US20170015725A1
公开(公告)日：2017-01-19
申请号：US15124080
申请日：2015-03-11
申请人： Allison D. Ortigosa , Michael P. Coleman , Shibu T. George , Michael A. Rauscher , Mark C. Sleevi , Kartoa Chow , Merck Sharp & Dohme Corp.
发明人： Allison D. Ortigosa , Michael P. Coleman , Shibu T. George , Michael A. Rauscher , Mark C. Sleevi , Kartoa Chow
摘要： A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.
摘要翻译： 描述了一种用于纯化胰岛素和胰岛素类似物的方法，其包括在水混溶性有机改性剂存在下进行酸性阳离子交换介质的高压液相色谱，并且在升高的温度下进行，随后在水存在下进行反相色谱 可混溶的有机改性剂和在高温下。
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公开(公告)号：US09955603B2
公开(公告)日：2018-04-24
申请号：US13610778
申请日：2012-09-11
申请人： Bryan P. Kiple , Charles B. Woodhull , David A. Pakula , Tang Y. Tan , Michael P. Coleman , Thomas Johannessen , Richard W. Heley
发明人： Bryan P. Kiple , Charles B. Woodhull , David A. Pakula , Tang Y. Tan , Michael P. Coleman , Thomas Johannessen , Richard W. Heley
IPC分类号： B29C47/00 , B22D11/126 , B22D11/128 , B23P17/00 , B23P25/00 , B23P11/00 , B21D39/00 , H05K5/04 , G03F1/38 , H01Q1/24 , H04M1/02 , H05K5/02 , H05K13/00 , C25D11/02 , C25D7/00 , C25D11/12 , H05K5/03 , H01Q1/42 , C25D11/34 , B23C5/10 , B23C5/00 , B23P17/02 , H04M1/11 , B23P13/04 , B23P19/04 , C25D11/24
CPC分类号： H05K5/04 , B23C5/00 , B23C5/1081 , B23C2220/04 , B23C2220/16 , B23C2220/20 , B23C2220/28 , B23C2220/48 , B23C2226/31 , B23C2226/315 , B23P11/00 , B23P17/00 , B23P17/02 , C25D7/00 , C25D11/02 , C25D11/022 , C25D11/12 , C25D11/246 , C25D11/34 , G03F1/38 , H01Q1/243 , H01Q1/42 , H04M1/0249 , H04M1/0254 , H04M1/11 , H05K5/02 , H05K5/0217 , H05K5/0243 , H05K5/0247 , H05K5/03 , H05K13/00 , Y10T29/47 , Y10T29/49002 , Y10T29/49826 , Y10T156/10 , Y10T156/1064 , Y10T407/1906 , Y10T409/300896 , Y10T409/303752 , Y10T409/30952
摘要： Various components of an electronic device housing and methods for their assembly are disclosed. The housing can be formed by assembling and connecting two or more different sections together. The sections of the housing may be coupled together using one or more coupling members. The coupling members may be formed using a two-shot molding process in which the first shot forms a structural portion of the coupling members, and the second shot forms cosmetic portions of the coupling members.
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公开(公告)号：US10421795B2
公开(公告)日：2019-09-24
申请号：US14652494
申请日：2013-12-12
申请人： Merck Sharp & Dohme Corp. , Michael P. Coleman , Allison D. Ortigosa , Mark C. Sleevi , Kartoa Chow
摘要： A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed under low to moderate pressure at an elevated temperature.
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公开(公告)号：US20130318766A1
公开(公告)日：2013-12-05
申请号：US13610778
申请日：2012-09-11
申请人： Bryan P. Kiple , Charles B. Woodhull , David A. Pakula , Tang Y. Tan , Michael P. Coleman , Thomas Johannessen , Richard W. Heley
发明人： Bryan P. Kiple , Charles B. Woodhull , David A. Pakula , Tang Y. Tan , Michael P. Coleman , Thomas Johannessen , Richard W. Heley
CPC分类号： H05K5/04 , B23C5/00 , B23C5/1081 , B23C2220/04 , B23C2220/16 , B23C2220/20 , B23C2220/28 , B23C2220/48 , B23C2226/31 , B23C2226/315 , B23P11/00 , B23P17/00 , B23P17/02 , C25D7/00 , C25D11/02 , C25D11/022 , C25D11/12 , C25D11/246 , C25D11/34 , G03F1/38 , H01Q1/243 , H01Q1/42 , H04M1/0249 , H04M1/0254 , H04M1/11 , H05K5/02 , H05K5/0217 , H05K5/0243 , H05K5/0247 , H05K5/03 , H05K13/00 , Y10T29/47 , Y10T29/49002 , Y10T29/49826 , Y10T156/10 , Y10T156/1064 , Y10T407/1906 , Y10T409/300896 , Y10T409/303752 , Y10T409/30952
摘要： Various components of an electronic device housing and methods for their assembly are disclosed. The housing can be formed by assembling and connecting two or more different sections together. The sections of the housing may be coupled together using one or more coupling members. The coupling members may be formed using a two-shot molding process in which the first shot forms a structural portion of the coupling members, and the second shot forms cosmetic portions of the coupling members.
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