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公开(公告)号:US08198275B2
公开(公告)日:2012-06-12
申请号:US13075213
申请日:2011-03-30
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/444 , A61K31/4155 , A61K31/16
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US3164174A
公开(公告)日:1965-01-05
申请号:US10407461
申请日:1961-04-19
申请人: LOUIS BERTHOD , MICHEL GRENON
发明人: LOUIS BERTHOD , MICHEL GRENON
IPC分类号: F16L55/052 , F22B37/42 , G05D16/18 , G21C1/09
CPC分类号: G21C1/09 , F16L55/052 , F22B37/42 , G05D16/18 , Y02E30/40
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公开(公告)号:US08440837B2
公开(公告)日:2013-05-14
申请号:US12908588
申请日:2010-10-20
申请人: Allen Hopper , Anette Graven Sams , Gitte Kobberoee Mikkelsen , Mathivanan Packiarajan , Michel Grenon
发明人: Allen Hopper , Anette Graven Sams , Gitte Kobberoee Mikkelsen , Mathivanan Packiarajan , Michel Grenon
IPC分类号: C07D275/02 , C07D277/00 , C07D415/00 , C07D413/00 , C07D265/36 , C07D403/00 , C07D215/00 , C07D513/02 , C07D401/00 , A61K31/397 , A61K31/55 , A61K31/535 , A61K31/44 , A61K31/445 , A61K31/425
CPC分类号: C07D277/24 , A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/496 , A61K31/5377 , C07D277/56 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/10 , C07D491/107 , C07D495/04
摘要: The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
摘要翻译: 本发明提供式(I)的2-取代的乙炔基噻唑衍生物:其中R1,R2和X如本文所定义,或其药学上可接受的盐; 和药物组合物及其使用方法。
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公开(公告)号:US08389519B2
公开(公告)日:2013-03-05
申请号:US13471611
申请日:2012-05-15
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/444 , A61K31/4155 , A61K31/16
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US20110178086A1
公开(公告)日:2011-07-21
申请号:US13075213
申请日:2011-03-30
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/444 , A61K31/4709 , A61K31/5377 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/16 , A61P25/24 , A61P25/06 , A61P1/04 , A61P25/32
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US20110092475A1
公开(公告)日:2011-04-21
申请号:US12908588
申请日:2010-10-20
申请人: Allen Hopper , Anette Graven Sams , Gitte Kobberoee Mikkelsen , Mathivanan Packiarajan , Michel Grenon
发明人: Allen Hopper , Anette Graven Sams , Gitte Kobberoee Mikkelsen , Mathivanan Packiarajan , Michel Grenon
IPC分类号: A61K31/397 , C07D401/06 , A61K31/454 , C07D417/06 , A61K31/427 , C07D413/06 , A61K31/5377 , C07D277/56 , A61K31/426 , A61K31/496 , C07D403/06 , A61K31/55 , C07D471/04 , A61K31/437 , C07D491/10 , A61K31/438 , A61K31/538 , A61P25/00
CPC分类号: C07D277/24 , A61K31/4025 , A61K31/426 , A61K31/427 , A61K31/435 , A61K31/496 , A61K31/5377 , C07D277/56 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/10 , C07D491/107 , C07D495/04
摘要: The present invention provides 2-substituted-ethynylthiazole derivatives of formula (I): wherein R1, R2 and X are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods of using same.
摘要翻译: 本发明提供式(I)的2-取代的乙炔基噻唑衍生物:其中R1,R2和X如本文所定义,或其药学上可接受的盐; 和药物组合物及其使用方法。
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公开(公告)号:US20100022546A1
公开(公告)日:2010-01-28
申请号:US12504711
申请日:2009-07-17
申请人: Hermogenes N. Jimenenz , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenenz , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/16 , C07D413/14 , C07D401/12 , C07C233/00
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (1): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(1)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US4045286A
公开(公告)日:1977-08-30
申请号:US642996
申请日:1975-12-22
CPC分类号: G21C1/32 , G21C1/03 , G21C1/22 , G21C15/02 , G21C15/24 , G21C3/54 , G21Y2002/103 , G21Y2002/30 , G21Y2004/30 , Y02E30/34 , Y02E30/35
摘要: In a molten-salt reactor, a common vessel contains the reactor core, a neutron-moderating mass pierced by passages for the circulation of the fuel salt, at least one primary heat exchanger which is located close to the reactor core and through which the hot fuel salt passes after discharge from the core, pumps for circulating the cold fuel salt from the heat exchangers back into the reactor core. The free spaces defined within the reactor vessel between the core, the heat exchangers and the pumps except for the passages in which the molten fuel salt is circulated are packed with material which is compatible with the fuel salt.
摘要翻译: 在熔盐反应器中,公共容器包含反应堆芯,用于燃料盐循环的通道刺穿的中子调节剂,至少一个位于反应堆芯附近的主要热交换器,通过该热交换器将热 燃料盐从核心排出后通过,用于将冷燃料盐从热交换器循环回到反应堆堆芯中。 在核心,热交换器和除了熔融燃料盐循环的通道之外的反应器容器内限定的自由空间用与燃料盐相容的材料填充。
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公开(公告)号:US20120270873A1
公开(公告)日:2012-10-25
申请号:US13471611
申请日:2012-05-15
申请人: Hermogenes N. JIMENEZ , Guiying LI , Dario DOLLER , Michel GRENON , Andrew D. WHITE , Gil MA , Maojun GUO
发明人: Hermogenes N. JIMENEZ , Guiying LI , Dario DOLLER , Michel GRENON , Andrew D. WHITE , Gil MA , Maojun GUO
IPC分类号: A61K31/16 , A61K31/44 , A61K31/4155 , A61K31/497 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/4965 , A61P25/00 , A61P25/28 , A61P25/22 , A61P25/18 , A61P25/16 , A61P25/24 , A61P29/00 , A61P25/32 , A61P1/04 , A61K31/444
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US07947680B2
公开(公告)日:2011-05-24
申请号:US12504711
申请日:2009-07-17
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/444 , A61K31/4155 , A61K31/16 , C07D413/14 , C07D401/02 , C07D403/02 , C07D213/56 , C07C233/00
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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