公开(公告)号：US5548404A

公开(公告)日：1996-08-20

申请号：US311263

申请日：1994-09-23

申请人： Vladimir Kupershmidt ,  Mikhail Kouchnir ,  Robert Petersen

发明人： Vladimir Kupershmidt ,  Mikhail Kouchnir ,  Robert Petersen

IPC分类号： G01N21/21 ,  G01J4/00

CPC分类号： G01N21/211

摘要： A method and apparatus for analyzing a sample wherein at least two orthogonally polarized, intensity and phase modulated laser beams with different wavelengths and frequencies of intensity and phase modulation are directed onto the sample, and the signals derived from the laser beams which interact with the sample are synchronously demodulated to determine characteristics of the sample such as index of refraction, absorption coefficient and film thickness. A reference beam can be provided to correct for noise and drift.

摘要翻译： 一种用于分析样品的方法和装置，其中具有不同波长和强度和相位调制频率的至少两个正交极化，强度和相位调制的激光束被引导到样品上，并且从与样品相互作用的激光束得到的信号 同步解调以确定样品的特性，例如折射率，吸收系数和膜厚度。 可以提供参考光束来校正噪声和漂移。

公开(公告)号：US20070179371A1

公开(公告)日：2007-08-02

申请号：US11528750

申请日：2006-09-27

申请人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir ,  Robert Blair

发明人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir ,  Robert Blair

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： G01N33/66 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6833 ,  A61B10/0064 ,  A61B2560/0412 ,  A61B2562/0295

摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.

摘要翻译： 这里描述了用于测量葡萄糖的补丁，系统和方法。 通常，贴片包括微流体收集层和检测器，并且系统包括贴片和测量装置。 用于测量葡萄糖的一些方法包括清洁皮肤表面，使用微流体收集装置从皮肤表面收集汗液，以及测量收集的葡萄糖。 其他方法包括清洁皮肤表面，在包含微量收集层的贴片中收集汗液，以及测量在贴片中收集的葡萄糖。 还有其它方法包括清洁皮肤表面，在包括微量收集层和检测器层的贴片中从皮肤表面收集第一汗液样品，将第一汗液样品从收集层转移到检测器层，测量第一汗液样品中的葡萄糖 汗液样品，并重复收集，转移和测量步骤至少一次。

公开(公告)号：US20060004271A1

公开(公告)日：2006-01-05

申请号：US11159587

申请日：2005-06-22

申请人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir

发明人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir

IPC分类号： A61B5/00

CPC分类号： A61B5/1455 ,  A61B5/14521 ,  A61B5/14532 ,  A61B2562/0295 ,  G01N33/66 ,  G06F19/00

摘要： Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.

摘要翻译： 描述了用于非侵入性测量葡萄糖的装置，方法和试剂盒。 通常，这些装置包括用于放置在皮肤表面上的皮肤贴片和用于测量在贴片中收集的葡萄糖的测量装置。 贴剂可以包括粘合剂材料，收集层，界面层和汗液渗透膜。 透汗膜被配置为作为通过扩散带到皮肤表面的表皮污染物和葡萄糖的屏障。 以这种方式，不能测量不相关的皮肤表面葡萄糖。 补片还可以包括诱发局部汗水反应的组件。 测量装置通常包括显示器，处理器和测量机构。 所述方法通常包括以下步骤：用含有至少一种用于除去葡萄糖的溶剂的擦拭物擦拭皮肤表面，将贴片放置在皮肤表面上，以及测量在贴剂中收集的葡萄糖。 还描述了包括贴剂和测量装置的试剂盒。

公开(公告)号：US20070027383A1

公开(公告)日：2007-02-01

申请号：US11451738

申请日：2006-06-12

申请人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir ,  Robert Blair

发明人： Thomas Peyser ,  Russell Potts ,  Herbert Berman ,  James Moyer ,  Mikhail Kouchnir ,  Robert Blair

IPC分类号： A61B5/05 ,  A61B5/00

CPC分类号： G01N33/66 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/6833 ,  A61B10/0064 ,  A61B2560/0412 ,  A61B2562/0295

摘要： Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.

公开(公告)号：US5515163A

公开(公告)日：1996-05-07

申请号：US299896

申请日：1994-09-01

申请人： Vladimir Kupershmidt ,  Mikhail Kouchnir

发明人： Vladimir Kupershmidt ,  Mikhail Kouchnir

IPC分类号： G01N15/02 ,  G01N21/41 ,  G01N21/00

CPC分类号： G01N15/0205 ,  G01N2015/0238 ,  G01N2021/1757 ,  G01N2021/4792 ,  G01N21/41

摘要： A method and an apparatus for the analysis of particles contained in a material, such as particles in a fluid or on a surface, such as the surface of a semiconductor, by two orthogonally polarized, intensity and phase modulated laser beams, wherein the detected scattered light is synchronously demodulated. The apparatus comprises a laser source producing a polarized laser beam, a state of polarization modulator, and a photoreceiver for detecting light scattered by particles at an angle to the incident light. A synchronous demodulator, such as a dual channel lock-in amplifier, separates the intensity and phase modulated portions of the scattered signals. A reference unit for detecting a non-scattered light produced by the sample to provide a reference is preferably provided, as well. The size, index of refraction and identity, of the particles, for example, can be determined.

摘要翻译： 通过两个正交极化的强度和相位调制的激光束分析包含在流体或表面上的诸如半导体的表面的材料中的颗粒所包含的颗粒的方法和装置，其中所检测的散射 光被同步解调。 该装置包括产生偏振激光束的激光源，偏振调制器的状态和用于检测与入射光成角度的颗粒散射的光的光接收器。 诸如双通道锁相放大器的同步解调器分离散射信号的强度和相位调制部分。 也优选提供用于检测由样品产生的非散射光以提供参考的参考单元。 例如，可以确定颗粒的尺寸，折射率和身份。