摘要:
Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要:
Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
摘要:
Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
摘要:
In one embodiment, an apparatus is provided. The apparatus includes a power bridge suitable for coupling to a CCFL (cold cathode fluorescent lamp) load and providing an operating current to the load. The apparatus also includes a replica component coupled to the power bridge to provide a replica current proportional to the operating current. The apparatus further includes a reference component receptacle to produce a reference current in conjunction with an external reference component. The apparatus also includes a comparison component coupled to the replica component and the reference component to compare the replica component to the reference component.
摘要:
A technique for driving one or more EEFLs, having first and second ends, in a bank of EEFLs involves driving the EEFLs at both the first and second ends. In a non-limiting embodiment, a device constructed according to the technique may include a bank of EEFLs connected in parallel. The device may further include a first transformer, wherein a first of the secondary windings of the first transformer is coupled to the first end of the bank of EEFLs. The device may further include a second transformer, wherein a first of the secondary windings of the second transformer is coupled to the second end of the bank of EEFLs.
摘要:
The present invention relates to a stable crystalline form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride designated the B polymorph, its production in essentially pure form, and its use. The invention also relates to the pharmaceutical compositions containing the stable polymorph B form of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine as hydrochloride, as well other forms of the compound, and to methods of treating hyperproliferative disorders, such as cancer, by administering the compound.
摘要:
An automated animal feeder is disclosed having a storage area with a top at one end and the second feeding into a dispensing module containing a dispensing tube. An auger, connected to a support and motor, extends into the second opening of the storage area. Preferably the auger support is movable along the dispensing module to vary a distance between the length of the auger at the proximal opening of the dispensing tube. A programmable control panel controls the motor and can have a display screen, speaker and programming members, or the control panel can be controlled by remote control. Power can be from at least one from the group of replaceable battery, rechargeable battery, solar or electricity, power the control panel and motor. A deflection tab extends into the dispensing tube, spaced from the auger, to prevent the accumulation food on the auger. The hanging member on the top can affixed to a stand with a post having a first end, a second end and a pivot point, the pivot point being affixed to the stand. The first end has a connection member for the hanging member and said second end has a rotation prevention member and an anchor. The post can rotate upon the release of the anchor to a predetermined distance from the ground as determined by the rotation prevention member or be locked in an upright position by said anchor.
摘要:
The present disclosure introduces a simple method and apparatus for converting DC power to AC power for driving discharge lamps such as a cold cathode fluorescent lamp (CCFL), an external electrode fluorescent lamp (EEFL), or a flat fluorescent lamp (FFL). Among other advantages, the invention allows the proper protection under short circuit conditions for applications where the normal lamp current is greater than safe current limit.
摘要:
The described DC to AC inverter efficiently controls the amount of electrical power used to drive a cold cathode fluorescent lamp (CCFL). The output is a fairly pure sine wave which is proportional to an input control voltage. The output waveform purity is ensured by driving a symmetrical rectangular waveform into a second-order, low pass filter at the resonant frequency of the filter for all conditions of line voltage and delivered power. Operating stress on the step-up transformer is minimized by placing the load (lamp) directly across the secondary side of the transformer. When configured to regulate delivered power, the secondary side may be fully floated which practically eliminates a thermometer effect on the operation of the lamp. All of the active elements, including the power switches, may be integrated into a monolithic silicon circuit.
摘要:
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.