公开(公告)号：US09324554B2

公开(公告)日：2016-04-26

申请号：US13818570

申请日：2011-08-25

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/42

CPC分类号： H01J49/4285 ,  H01J49/422 ,  H01J49/4225

摘要： A system and method involving processing ions in a linear ion trap are provided, involving a two-dimensional asymmetric substantially quadrupole field having a hexapole and octopole component.

摘要翻译： 提供了涉及在线性离子阱中处理离子的系统和方法，涉及具有六极和八极分量的二维不对称基本四极场。

公开(公告)号：US08309914B2

公开(公告)日：2012-11-13

申请号：US12359526

申请日：2009-01-26

申请人： Mircea Guna ,  Yves Le Blanc ,  Bruce Collings

发明人： Mircea Guna ,  Yves Le Blanc ,  Bruce Collings

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/426 ,  H01J49/0063 ,  H01J49/24

摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10−5 Torr to about 5×10−4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.

摘要翻译： 描述了在离子阱中分离离子的方法。 这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的工作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供至少10％的离子阱内的工作压力的非稳态压力增加，以提高离子中的压力 在第一升高压力持续时间内，在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留碎片 的离子阱内的母离子。 激发时间间隔和第一升高压力时间基本上在时间上重叠。

公开(公告)号：US20090302215A1

公开(公告)日：2009-12-10

申请号：US12480160

申请日：2009-06-08

申请人： Mircea Guna ,  Frank Londry

发明人： Mircea Guna ,  Frank Londry

IPC分类号： B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/0031 ,  H01J49/004

摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

摘要翻译： 提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）在第三时间将第二多个离子从第一离子阱中传出并进入第二离子阱。

公开(公告)号：US08766171B2

公开(公告)日：2014-07-01

申请号：US13416352

申请日：2012-03-09

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J3/00 ,  H01J49/42 ,  H01J49/26

CPC分类号： H01J49/4225 ,  H01J49/427

摘要： A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmonic with amplitude An present in the field, n being any integer greater than 2 except 4, A4 is greater than ten times An.

摘要翻译： 提供二维基本四极场。 该场包括振幅A2的四极谐波和振幅A4的八极谐波，其中A4大于A2的0.01％，A4小于A2的5％，并且对于具有振幅A的任何其它高阶谐波，存在于 场，n除了4以外大于2的任何整数，A4大于An的十倍。

公开(公告)号：US20130181125A1

公开(公告)日：2013-07-18

申请号：US13817189

申请日：2011-08-18

申请人： Mircea Guna ,  Bruce Collings

发明人： Mircea Guna ,  Bruce Collings

IPC分类号： H01J49/00 ,  H01J49/06

CPC分类号： H01J49/0031 ,  H01J49/025 ,  H01J49/06 ,  H01J49/061

摘要： A mass spectrometer system can include a mass analyzer operable to mass transmit streams of ions to a detector in a mass dependent fashion for measurement of ion flux intensity. An ion attenuator can be located in the extraction region between the mass analyzer and detector, downstream of the mass analyzer, and can be operable to provide selective attenuation of the ion beam by attenuating ion flux intensity also in mass dependent fashion. Higher concentration ions can be selected and attenuated, while other lower concentration ions can be left unattenuated. Different ions can be attenuated to different degrees. Locating the ion attenuator downstream of the mass analyzer so that the ion beam is already mass differentiated when attenuated can avoid mass discriminatory effects associated with ion beam attenuators. Selective attenuation of only certain ions but not others can extend the dynamic range of the detector without necessarily sacrificing detector sensitivity.

摘要翻译： 质谱仪系统可以包括质量分析器，其可以质量传递离子流到检测器以质量依赖的方式来测量离子通量强度。 离子衰减器可以位于质量分析器和检测器之间的质量分析器下游的提取区域中，并且可以通过以质量依赖的方式衰减离子通量强度来操作来提供离子束的选择性衰减。 可以选择和减弱更高浓度的离子，而其他低浓度离子可以保持不衰减。 不同的离子可以衰减到不同的程度。 将离子衰减器定位在质量分析仪的下游，以便当衰减时离子束已经被质量分化，可以避免与离子束衰减器相关的质量差异影响。 只有某些离子而不是其他离子的选择性衰减可以扩展检测器的动态范围，而不必牺牲检测器灵敏度。

公开(公告)号：US08168944B2

公开(公告)日：2012-05-01

申请号：US12830384

申请日：2010-07-05

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/42 ,  H01J49/26

CPC分类号： H01J49/427 ,  H01J49/4225

摘要： A two-dimensional substantially quadrupole field is provided. The field comprises a quadrupole harmonic of amplitude A2 and an octopole harmonic of amplitude A4, wherein A4 is greater than 0.01% of A2, A4 is less than 5% of A2, and, for any other higher order harmonic with amplitude An present in the field, n being any integer greater than 2 except 4, A4 is greater than ten times An.

摘要翻译： 提供二维基本四极场。 该场包括振幅A2的四极谐波和振幅A4的八极谐波，其中A4大于A2的0.01％，A4小于A2的5％，并且对于具有振幅A的任何其它高阶谐波，存在于 场，n除了4以外大于2的任何整数，A4大于An的十倍。

公开(公告)号：US07880140B2

公开(公告)日：2011-02-01

申请号：US11743176

申请日：2007-05-02

申请人： Michael-Mircea Guna ,  James Hager

发明人： Michael-Mircea Guna ,  James Hager

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/4215

摘要： A multipole mass filter having improved mass resolution. The multipole mass filer having a first electrode set coupled to at least a RF voltage source and a second electrode set interposed and parallel to the first electrode set. The second electrode set having a variable AC voltage coupled to two radially opposing electrodes of the second electrode set.

摘要翻译： 具有改进的质量分辨率的多极质量过滤器。 多极质量滤波器具有耦合到至少RF电压源的第一电极组和插入并平行于第一电极组的第二电极组。 第二电极组具有耦合到第二电极组的两个径向对置电极的可变AC电压。

公开(公告)号：US20090194683A1

公开(公告)日：2009-08-06

申请号：US12359471

申请日：2009-01-26

申请人： Mircea Guna ,  Yves Le Blanc

发明人： Mircea Guna ,  Yves Le Blanc

IPC分类号： B01D59/44

CPC分类号： H01J49/4295 ,  H01J49/0063 ,  H01J49/422

摘要： In accordance with an aspect of an embodiment of the present invention, there is provided a method for fragmenting ions in an ion trap of a mass spectrometer. The method comprises a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; and, e) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap.

摘要翻译： 根据本发明的实施方案的一个方面，提供了一种用于在质谱仪的离子阱中分离离子的方法。 该方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的操作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; 并且e）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低至小于保持的兴奋水平的保持水平 离子阱内母离子的碎片。

公开(公告)号：US09318310B2

公开(公告)日：2016-04-19

申请号：US14131972

申请日：2012-07-11

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： H01J49/42 ,  H01J49/00

CPC分类号： H01J49/4265 ,  H01J49/004 ,  H01J49/422 ,  H01J49/427

摘要： A method for operating a mass spectrometer having an ion trap over a plurality of selected mass-to-charge ranges constituting an overall mass-to-charge range is disclosed. For each of the plurality of selected mass-to-charge ranges the method comprises filling the ion trap with fragmented ions of the selected mass-to-charge ranges, cooling the fragmented ions trapped in the ion trap for a first cooling period, applying an RF voltage and a resolving direct current voltage to the ion trap for eliminating any remaining fragmented ions outside the selected ion mass-to-charge range and retaining ions within the selected ion mass-to-charge range, cooling the retained ions in the ion trap for a second cooling period, and scanning the retained ions out of the ion trap and detecting the ions released therefrom.

摘要翻译： 公开了一种在构成整体质量 - 电荷范围的多个选定的质量 - 电荷范围内操作具有离子阱的质谱仪的方法。 对于多个选择的质量 - 电荷范围中的每一个，该方法包括用选择的质量 - 电荷范围的碎片离子填充离子阱，冷却在第一冷却期间捕集在离子阱中的碎裂离子， RF电压和分离到离子阱的直流电压，用于消除选定的离子质量 - 电荷范围之外的任何剩余的分散离子，并将离子保持在所选择的离子质量 - 电荷范围内，冷却离子阱中的保留离子 在第二冷却期间，并将残留的离子从离子阱中扫描出来并检测从其释放的离子。

公开(公告)号：US08822916B2

公开(公告)日：2014-09-02

申请号：US13340176

申请日：2011-12-29

申请人： Mircea Guna

发明人： Mircea Guna

IPC分类号： B01D59/44 ,  H01J49/00 ,  H01J49/42 ,  H01J49/06

CPC分类号： H01J49/4265 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/061 ,  H01J49/26

摘要： A method for operating tandem ion traps is provided, involving a) accumulating ions in the first ion trap at a first time; b) transmitting a first plurality of ions out of the first ion trap and into the second ion trap at a second time, the first plurality of ions having masses within a first mass range; c) retaining a second plurality of ions in the first ion trap at the second time, the second plurality of ions having masses within a second mass range different from the first mass range; d) transmitting the first plurality of ions out of the second ion trap at a third time; and, e) transmitting the second plurality of ions out of the first ion trap and into the second ion trap at the third time.

摘要翻译： 提供了一种用于操作串联离子阱的方法，包括：a）在第一时间将第一离子阱中的离子累积; b）在第二时间将第一多个离子从第一离子阱中传输到第二离子阱中，第一多个离子具有在第一质量范围内的质量; c）在第二时间将第二多个离子保留在第一离子阱中，第二多个离子具有在与第一质量范围不同的第二质量范围内的质量; d）第三次将第一多个离子从第二离子阱中传出; 以及e）第三次将第二多个离子从第一离子阱中传出并进入第二离子阱。