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公开(公告)号：US08236770B2
公开(公告)日：2012-08-07
申请号：US10594553
申请日：2005-03-29
CPC分类号： A61K9/1272 , A61K9/127 , Y10S977/907 , Y10T428/2984
摘要： The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.
摘要翻译： 本发明涉及两性脂质体制剂，其具有很高的血清稳定性并且适用于寡核苷酸的细胞内递送。
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公开(公告)号：US20090199313A1
公开(公告)日：2009-08-06
申请号：US11977973
申请日：2007-10-26
申请人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
发明人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
IPC分类号： A01H5/00 , G01N33/48 , C12Q1/00 , C12N9/00 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/21 , C12N1/19 , C12N5/04 , C12N1/11
CPC分类号： C12N9/00 , C12N15/52 , C12N15/8274 , C12P9/00
摘要： The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for conferring herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
摘要翻译： 本发明涉及2-甲基-D-赤藓糖醇2,4-环丙基磷酸酯和异戊烯基焦磷酸或二甲基烯丙基焦磷酸的上游的非甲羟戊酸异戊二烯通路的酶和中间体。 这些用作这些酶的抑制剂的筛选方法的基础，以及用于鉴定其抑制剂抗性变体的方法。 还涉及编码所述酶和其抑制剂抗性变体的DNA，含有所述DNA的载体，含有所述载体的细胞，以及含有所述载体的细胞的植物种子。 本发明可用于抑制植物，细菌和原生动物中的类异戊二烯的生物合成，以赋予对植物的除草剂抗性，以及使用含有除草剂抗性基因的作物和有效量的 合适的除草剂。
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公开(公告)号：US20080311181A1
公开(公告)日：2008-12-18
申请号：US10594553
申请日：2005-03-29
IPC分类号： A61K9/127 , A61K31/7088 , A61P43/00
CPC分类号： A61K9/1272 , A61K9/127 , Y10S977/907 , Y10T428/2984
摘要： The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.
摘要翻译： 本发明涉及两性脂质体制剂，其具有很高的血清稳定性并且适用于寡核苷酸的细胞内递送。
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公开(公告)号：US07288367B2
公开(公告)日：2007-10-30
申请号：US10296416
申请日：2001-06-01
申请人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
发明人： Adelbert Bacher , Meinhart H. Zenk , Petra Adam , Wolfgang Eisenreich , Monika Fellermeier , Stefan Hecht , Felix Rohdich , Christoph A. Schuhr , Juraithip Wungsintaweekul
IPC分类号： C12Q1/00
CPC分类号： C12N9/00 , C12N15/52 , C12N15/8274 , C12P9/00
摘要： The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
摘要翻译： 本发明涉及2-甲基-D-赤藓糖醇2,4-环丙基磷酸酯和异戊烯基焦磷酸或二甲基烯丙基焦磷酸的上游的非甲羟戊酸异戊二烯通路的酶和中间体。 这些用作这些酶的抑制剂的筛选方法的基础，以及用于鉴定其抑制剂抗性变体的方法。 还涉及编码所述酶和其抑制剂抗性变体的DNA，含有所述DNA的载体，含有所述载体的细胞，以及含有所述载体的细胞的植物种子。 本发明可用于抑制植物，细菌和原生动物中的类异戊二烯的生物合成，以赋予对植物的除草剂抗性，以及在使用含有除草剂抗性基因的作物和有效量的 合适的除草剂。
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公开(公告)号：US07534742B2
公开(公告)日：2009-05-19
申请号：US11526318
申请日：2006-09-25
申请人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
发明人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
IPC分类号： C40B30/04
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.
摘要翻译： 本发明涉及涉及类异戊二烯生物合成的酶活性以及在类异戊二烯的生物合成中用于酶的抑制剂，特别是除草剂。 更具体地，本发明涉及用于检测这些抑制剂的筛选方法和用于进行所述方法的酶活性蛋白质以及编码这种蛋白质的纯化的分离的DNA。 此外，本发明涉及可通过所述筛选方法检测的新型抑制剂，以及用于抑制类异戊二烯的合成和基于所述抑制剂控制生物体的生长的组合物和方法。 本发明还涉及抑制剂抗性植物酶和植物，植物组织，植物种子和植物细胞的发展。
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公开(公告)号：US20070015216A1
公开(公告)日：2007-01-18
申请号：US11526318
申请日：2006-09-25
申请人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Luttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart Zenk
发明人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Luttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart Zenk
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibitors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.
摘要翻译： 本发明涉及涉及类异戊二烯生物合成的酶活性以及在类异戊二烯的生物合成中用于酶的抑制剂，特别是除草剂。 更具体地，本发明涉及用于检测这些抑制剂的筛选方法和用于进行所述方法的酶活性蛋白质以及编码这种蛋白质的纯化的分离的DNA。 此外，本发明涉及可通过所述筛选方法检测的新型抑制剂，以及用于抑制类异戊二烯的合成和基于所述抑制剂控制生物体的生长的组合物和方法。 本发明还涉及抑制剂抗性植物酶和植物，植物组织，植物种子和植物细胞的发展。
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公开(公告)号：US07122331B1
公开(公告)日：2006-10-17
申请号：US10048874
申请日：2000-08-03
申请人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
发明人： Wolfgang Eisenreich , Monika Fellermeier , Markus Fischer , Stefan Hecht , Stefan Herz , Klaus Kis , Holger Lüttgen , Felix Rohdich , Silvia Sagner-Grehn , Christoph A. Schuhr , Jurathip Wungsintaweekul , Adelbert Bacher , Meinhart H. Zenk
IPC分类号： G01N33/573
CPC分类号： C12N9/1229 , C12N9/1205 , C12N9/88 , C12P23/00
摘要： The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as purified isolated DNA coding for such proteins. Moreover, the present invention relates to novel inhibitors detectable by said screening methods as well as compositions and processes for inhibiting the synthesis of isoprenoids and for controlling the growth of organisms based on said inhibiors. The invention relates also to the development of inhibitor-resistant plant enzymes and plants, plant tissues, plant seeds and plant cells.
摘要翻译： 本发明涉及涉及类异戊二烯生物合成的酶活性以及在类异戊二烯的生物合成中用于酶的抑制剂，特别是除草剂。 更具体地，本发明涉及用于检测这些抑制剂的筛选方法和用于进行所述方法的酶活性蛋白质以及编码这种蛋白质的纯化的分离的DNA。 此外，本发明涉及可通过所述筛选方法检测的新型抑制剂以及用于抑制类异戊二烯的合成和基于所述抑制剂控制生物体的生长的组合物和方法。 本发明还涉及抑制剂抗性植物酶和植物，植物组织，植物种子和植物细胞的发展。
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