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    WATERPROOF GLOVES AND MANUFACTURING METHOD THEREOF
    2.
    发明申请
    WATERPROOF GLOVES AND MANUFACTURING METHOD THEREOF 审中-公开
    防水手套及其制造方法

    公开(公告)号：US20100154099A1

    公开(公告)日：2010-06-24

    申请号：US12625547

    申请日：2009-11-24

    申请人： Myung-Chul LEE

    发明人： Myung-Chul LEE

    IPC分类号： A41D19/00 ,  B32B38/04

    CPC分类号： A41D19/0006 ,  A41D31/102 ,  A41D2300/52 ,  Y10T156/1062

    摘要： A waterproof glove has an outer shell, an inner liner and an intermediate liner interposed therebetween. Adhesive members are attached to predetermined portions of an outer surface of the inner liner and predetermined portions of an outer surface of the intermediate liner, adhesion parts are formed on first surfaces of the adhesive members which will come into close contact with the outer surface of the inner liner and the outer surface of the intermediate liner, and hot melt parts are formed on second surfaces of the adhesive members which will come into close contact with an inner surface of the intermediate liner and an inner surface of the outer shell.

    摘要翻译： 防水手套具有外壳，内衬和介于其间的中间衬垫。 粘合构件附接到内衬的外表面的预定部分和中间衬垫的外表面的预定部分，粘合部分形成在粘合剂构件的第一表面上，该第一表面将与第二衬垫的外表面紧密接触 内衬和中间衬套的外表面，并且热熔部分形成在将与中间衬套的内表面和外壳的内表面紧密接触的粘合构件的第二表面上。

    Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques
    3.
    发明申请
    Benzylideneaniline derivatives and their radioisotope labeled compounds for binding and imaging of beta-amyloid plaques 审中-公开
    苯亚甲基苯胺衍生物及其放射性同位素标记化合物，用于结合和成像β-淀粉样蛋白斑

    公开(公告)号：US20070122341A1

    公开(公告)日：2007-05-31

    申请号：US11424741

    申请日：2006-06-16

    申请人： Jae Min Jeong ,  Dong Soo Lee ,  June-Key Chung ,  Myung Chul Lee

    发明人： Jae Min Jeong ,  Dong Soo Lee ,  June-Key Chung ,  Myung Chul Lee

    IPC分类号： A61K51/00 ,  C07D249/02

    CPC分类号： A61K51/04 ,  C07C251/24

    摘要： Benzylideneaniline derivatives of formula 1 wherein R1-R5 are independently selected from hydrogen, C1-C4 alkyl and F (at least one of them is F) and each R6-R10 are independently selected from hydrogen, C1-C4 alkyl, OH, OCH3, NH2, NHCH3 and N(CH3)2 (at least one of them is OH, OCH3, NH2, NHCH3 or N(CH3)2) are disclosed. Benzylideneaniline derivatives according to the present invention have high affinity to β-amyloid plaques. Thus, they can cross the blood-brain-barrier (BBB) and bind to β-amyloid plaques after administration into the body, making them useful for treatment, prevention, or imaging of Alzheimer's disease.

    摘要翻译： 式1的亚苄基苯胺衍生物，其中R 1 -R 5独立地选自氢，C 1 -C 4烷基和F（其中至少一个为F） 取代基，其中R 1，R 2，R 2，R 3，R 4，R 6， 3，NH 2，NHCH 3和N（CH 3）2）（至少一个 它们是OH，OCH 3，NH 2，NHCH 3或N（CH 3 3） 2 ）。 根据本发明的亚苄基苯胺衍生物对β-淀粉样蛋白斑具有高亲和力。 因此，它们可以穿过血脑屏障（BBB）并且在施用于体内后与β-淀粉样蛋白斑结合，使其可用于治疗，预防或成像阿尔茨海默氏病。

    Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition
    4.
    发明授权
    Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition 有权
    二硫代二醇衍生物及其镭或镭鎓络合物; 包含镭配合物和碘油的肝癌治疗组合物; 以及用于制备肝癌治疗组合物的试剂盒

    公开(公告)号：US07067508B2

    公开(公告)日：2006-06-27

    申请号：US10469198

    申请日：2002-03-08

    申请人： Jae Min Jeong ,  Young Ju Kim ,  Yun-Sang Lee ,  Dong Soo Lee ,  June-Key Chung ,  Myung Chul Lee

    发明人： Jae Min Jeong ,  Young Ju Kim ,  Yun-Sang Lee ,  Dong Soo Lee ,  June-Key Chung ,  Myung Chul Lee

    IPC分类号： A01N43/00 ,  A61K31/33

    CPC分类号： C07D285/00 ,  C07C323/41 ,  C07F13/005 ,  Y02P20/55

    摘要： The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a preparative kit of the composition for treating liver cancer.In the composition according to the invention, the diaminedithiol derivative is a novel compound in which long chain alkyl groups were introduced to diaminedithiol, capable of forming a radiorhenium or radiotechnetium complex thereof with an ease and leading to stronger van der Waals bonds with lipiodol. As a result, the complex becomes more stable in a medium, lipiodol, whereby the composition of the invention exhibits a high accumulation rate in liver cancer tissue when injected via hepatic artery, thereby capable of achieving an efficient treatment of liver cancer.

    摘要翻译： 本发明涉及一种新的二硫二硫醇衍生物或其药学上可接受的盐; 镭或其无机技术复合物; 用于治疗肝癌的组合物，其包含铑络合物和碘油; 和用于治疗肝癌的组合物的制备试剂盒。 在本发明的组合物中，二硫二硫醇衍生物是一种新的化合物，其中长链烷基被引入到二硫代二醇中，能够容易地形成其镭或镭鎓络合物，并导致与碘碘醇更强的范德华力键。 结果，复合物在培养基，碘油中变得更稳定，由此本发明的组合物通过肝动脉注射时在肝癌组织中表现出高的积累速率，从而能够实现肝癌的有效治疗。

    Complex of bifunctional chelating agent and mannosyl human serum albumin
    7.
    发明授权
    Complex of bifunctional chelating agent and mannosyl human serum albumin 有权
    双功能螯合剂和甘露糖基人血清白蛋白的复合物

    公开(公告)号：US08911706B2

    公开(公告)日：2014-12-16

    申请号：US13146280

    申请日：2010-01-27

    申请人： Jae Min Jeong ,  Myung Chul Lee ,  June Key Chung ,  Dong Soo Lee

    发明人： Jae Min Jeong ,  Myung Chul Lee ,  June Key Chung ,  Dong Soo Lee

    IPC分类号： A61K51/00 ,  A61K36/14 ,  A61K51/08 ,  A61K51/04

    CPC分类号： A61K51/081 ,  A61K51/0482

    摘要： The present invention is about bifunctional chelating agents (BCA) conjugated mannosyl human serum albumin (MSA) and its radioisotope labeled compounds for imaging immune system such as macrophages, Kupffer cells, reticuloendothelial system (RES), and lymphatic system. The present invention comprises BCA-MSA conjugates, their radiolabeled compounds, and kits for radiolabeing. The present invention improved radiolabeling procedure, showed higher lymphatic system uptake, and enabled image by positron emission tomography (PET).

    摘要翻译： 本发明涉及双功能螯合剂（BCA）共轭甘露糖基人血清白蛋白（MSA）及其放射性同位素标记化合物，用于成像免疫系统如巨噬细胞，枯否细胞，网状内皮系统（RES）和淋巴系统。 本发明包括BCA-MSA缀合物，它们的放射性标记化合物和放射性试剂盒。 本发明改善放射性标记程序，显示较高的淋巴系统摄取，并通过正电子发射断层扫描（PET）实现图像。

    COMPLEX OF BIFUNCTIONAL CHELATING AGENT AND MANNOSYL HUMAN SERUM ALBUMIN
    9.
    发明申请
    COMPLEX OF BIFUNCTIONAL CHELATING AGENT AND MANNOSYL HUMAN SERUM ALBUMIN 有权
    双功能螯合剂和曼氏人血清白蛋白复合物

    公开(公告)号：US20110286920A1

    公开(公告)日：2011-11-24

    申请号：US13146280

    申请日：2010-01-27

    申请人： Jae Min Jeong ,  Myung Chul Lee ,  June Key Chung ,  Dong Soo Lee

    发明人： Jae Min Jeong ,  Myung Chul Lee ,  June Key Chung ,  Dong Soo Lee

    IPC分类号： A61K51/08 ,  C07K14/765

    CPC分类号： A61K51/081 ,  A61K51/0482

    摘要： The present invention is about bifunctional chelating agents (BCA) conjugated mannosyl human serum albumin (MSA) and its radioisotope labeled compounds for imaging immune system such as macrophages, Kupffer cells, reticuloendothelial system (RES), and lymphatic system. The present invention comprises BCA-MSA conjugates, their radiolabeled compounds, and kits for radiolabeing. The present invention improved radiolabeling procedure, showed higher lymphatic system uptake, and enabled image by positron emission tomography (PET).

    摘要翻译： 本发明涉及双功能螯合剂（BCA）共轭甘露糖基人血清白蛋白（MSA）及其放射性同位素标记化合物，用于成像免疫系统如巨噬细胞，枯否细胞，网状内皮系统（RES）和淋巴系统。 本发明包括BCA-MSA缀合物，它们的放射性标记化合物和放射性试剂盒。 本发明改善放射性标记程序，显示较高的淋巴系统摄取，并通过正电子发射断层扫描（PET）实现图像。