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8 条记录 (耗时 0.016 秒)

    Human 7-transmembrane receptor and DNA
    5.
    发明授权
    Human 7-transmembrane receptor and DNA 失效
    人类7-跨膜受体和DNA

    公开(公告)号：US5824504A

    公开(公告)日：1998-10-20

    申请号：US742011

    申请日：1996-10-31

    申请人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    发明人： Nabil A. Elshourbagy ,  Derk J. Bergsma ,  Catherine E. Ellis

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K48/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P19/10 ,  A61P25/00 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P37/08 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/91 ,  C12N15/63 ,  C12N15/85

    CPC分类号： C07K14/7158 ,  A61K38/00

    摘要： Human HBMBU14 polypeptides and DNA (RNA) encoding such HBMBU14 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HBMBU14 for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 and HIV-2, pain, cancers, anorexia, bulimia, asthma, Parkinson's disease, acute heart failure, atherosclerosis, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourette's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HBMBU14 and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人HBMBU14多肽和编码这种HBMBU14的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种HBMBU14来治疗感染例如细菌，真菌，原生动物和病毒感染的方法，特别是HIV-1和HIV-2引起的感染，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病，急性 心力衰竭，动脉粥样硬化，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗塞，溃疡，哮喘，过敏，良性前列腺肥大和精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝 ，以及运动障碍，如亨廷顿病或吉列斯·杜拉图雷特综合征等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码HBMBU14的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    Human cardiac/brain tolloid-like protein
    6.
    发明授权
    Human cardiac/brain tolloid-like protein 失效
    人类心脏/脑体外样蛋白

    公开(公告)号：US06365715B1

    公开(公告)日：2002-04-02

    申请号：US09432473

    申请日：1999-11-01

    申请人： Anthony J Arleth ,  Nabil A Elshourbagy ,  Xiaotong Li ,  Robert N Willette

    发明人： Anthony J Arleth ,  Nabil A Elshourbagy ,  Xiaotong Li ,  Robert N Willette

    IPC分类号： C07K14435

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  A61K39/00 ,  C07K14/51

    摘要： HC/BTLP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing hC/BTLP polypeptides and polynucleotides in the design of protocols for the treatment of restenosis, atherosclerosis, congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), benign prostatic hypertrophy (BPH), nephritis, fibrosis, glomerulonephritis, gliosis, cirrhosis and anomalies of wound healing, such as keloids among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了通过重组技术制备此类多肽的HC / BTLP多肽和多核苷酸和方法。 还公开了在设计用于治疗再狭窄，动脉粥样硬化，充血性心力衰竭（CHF），慢性阻塞性肺病（COPD），良性前列腺肥大（BPH），肾炎，纤维化）的方案中使用hC / BTLP多肽和多核苷酸的方法 ，肾小球性肾炎，神经胶质增生，肝硬化和伤口愈合的异常，例如瘢痕疙瘩等，以及这些病症的诊断测定。

    7TM receptor (H2CAA71)
    7.
    发明授权
    7TM receptor (H2CAA71) 失效
    7TM受体（H2CAA71）

    公开(公告)号：US06174994B1

    公开(公告)日：2001-01-16

    申请号：US09153593

    申请日：1998-09-15

    申请人： Nabil A Elshourbagy ,  Xiaotong Li ,  Derk J Bergsma

    发明人： Nabil A Elshourbagy ,  Xiaotong Li ,  Derk J Bergsma

    IPC分类号： C07K14705

    CPC分类号： C07K14/723 ,  A61K38/00

    摘要： Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了新型7TM受体（H2CAA71）多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用Novel 7TM受体（H2CAA71）多肽和多核苷酸的方法; 疼痛; 癌症; 厌食症 贪食 哮喘; 帕金森病 急性心力衰竭 低血压 高血压; 尿潴留 骨质疏松症 心绞痛; 心肌梗死; 溃疡 哮喘; 过敏 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征以及这些病症的诊断测定。