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    Formulations including digestive enzymes, polysorbate-based surfactants and probiotics
    2.
    发明授权
    Formulations including digestive enzymes, polysorbate-based surfactants and probiotics 有权
    制剂包括消化酶，聚山梨醇酯类表面活性剂和益生菌

    公开(公告)号：US08722035B2

    公开(公告)日：2014-05-13

    申请号：US13267042

    申请日：2011-10-06

    Applicant: Randolph S. Porubcan

    Inventor： Randolph S. Porubcan

    IPC: A61K33/00 ,  A61K33/06 ,  A61K38/43 ,  A01N59/00 ,  A01N59/06 ,  A01N63/00 ,  C12N1/12 ,  C12N1/20 ,  C12N9/00 ,  C12P1/04

    CPC classification number: A61K9/148 ,  A61K35/747 ,  A61K38/47 ,  A61K38/4873 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y304/22002 ,  C12Y304/22033 ,  Y10S435/822 ,  Y10S435/853 ,  Y10S435/854 ,  Y10S435/855 ,  Y10S435/856 ,  Y10S435/857 ,  A61K2300/00

    Abstract: Disclosed are formulations for enhancing the in vivo colonization of probiotic microorganisms that include digestive enzymes and probiotic microorganisms, and polysorbate surfactants. The enzymes include lactogenic enzyme formulations that promote growth of Lactobacillus probiotics, bifidogenic enzyme formulations that promote growth of Bifidobacterium probiotics and combination formulations that benefit both types of probiotics. It has been discovered that certain polysorbate surfactants, including polysorbate-60 and polysorbate-80, further promote probiotic microorganism growth, when used with the enzyme formulations. The formulations are preferably compounded as dry powders, to avoid water reaction with the enzymes in blended formulations. Such formulations can be contained in capsules, tablets, packets or bottles and administered orally, either sequentially or in one combined formulation.

    Abstract translation: 公开了用于增强包括消化酶和益生菌微生物在内的益生菌微生物的体内定植的制剂和聚山梨酯表面活性剂。 酶包括促进益生菌乳杆菌生长的促生长酶制剂，促进双歧杆菌益生菌生长的双歧杆菌酶制剂以及有益于两种益生菌的组合制剂。 已经发现，当与酶制剂一起使用时，某些聚山梨醇酯表面活性剂，包括聚山梨酯-60和聚山梨酯-80，进一步促进益生菌微生物的生长。 制剂优选以干燥粉末形式混合，以避免与混合制剂中的水反应水。 这样的制剂可以包含在胶囊，片剂，包装或瓶子中，并且以顺序或一种组合的制剂口服给药。

    Compositions and methods for inhibiting pathogenic growth
    3.
    发明授权
    Compositions and methods for inhibiting pathogenic growth 有权
    抑制病原生长的组合物和方法

    公开(公告)号：US07291327B2

    公开(公告)日：2007-11-06

    申请号：US10905216

    申请日：2004-12-21

    Applicant: Bryan E. Garner ,  Douglas R. Ware

    Inventor： Bryan E. Garner ,  Douglas R. Ware

    IPC: A61K45/00

    CPC classification number: A61K35/742 ,  A23K10/18 ,  A23K50/10 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  Y10S435/822 ,  Y10S435/854 ,  A61K2300/00

    Abstract: The invention includes methods and compositions for treating an animal to inhibit the incidence and growth of E. coli O157:H7 and other pathogenic bacteria. The treatment method comprises administering a therapeutically effective amount of Lactobacillus acidophilus or one or a combination of a number of other probiotic bacteria to an animal. An alternative treatment method comprises administering a therapeutically effective amount of a lactic acid producing bacterium such as Lactobacillus acidophilus in combination with a lactate utilizing bacterium such as Propionibacterium freudenreichii.

    Abstract translation: 本发明包括用于治疗动物以抑制大肠杆菌O157：H7和其他致病菌的发生和生长的方法和组合物。 治疗方法包括向动物施用治疗有效量的嗜酸乳杆菌或许多其它益生菌的一种或组合。 一种替代治疗方法包括使用细菌如弗氏藤丙酸杆菌，将治疗有效量的产酸乳酸菌如嗜酸乳杆菌与乳酸组合施用。

    Antiallergic agent, utilization thereof for reducing allergy and method of reducing allergy
    5.
    发明申请
    Antiallergic agent, utilization thereof for reducing allergy and method of reducing allergy 审中-公开
    抗过敏剂，其用于减轻过敏的用途和减轻过敏的方法

    公开(公告)号：US20050214270A1

    公开(公告)日：2005-09-29

    申请号：US10518801

    申请日：2003-06-26

    Applicant: Naouki Yamamoto ,  Yuu Ishida ,  Izuki Bando

    Inventor： Naouki Yamamoto ,  Yuu Ishida ,  Izuki Bando

    IPC: A61K35/74 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P37/08 ,  A61P43/00 ,  A61K45/00 ,  C12N1/20

    CPC classification number: A61K35/747 ,  Y10S435/854

    Abstract: The present invention provides an antiallergic agent containing, as an active ingredient, lactic acid bacteria selected from the group consisting of lactic acid bacteria of the species Lactobacillus acidophilus, Lactobacillus fermentum, and combinations thereof. The antiallergic agent is capable of improving allergic diathesis by reducing the IgE level, which is contributive to development of Type I allergy, and is easy to take and highly safe. The present invention also provides use of the antiallergic agent for reducing allergy, and a method for reducing allergy using the antiallergic agent.

    Abstract translation: 本发明提供一种抗过敏剂，其含有选自嗜酸乳酸杆菌乳酸菌，发酵乳杆菌及其组合的乳酸菌作为活性成分。 抗过敏剂能够通过降低IgE水平来改善过敏反应，这有助于I型过敏的发生，并且易于服用和高度安全。 本发明还提供抗过敏剂用于降低过敏的用途，以及使用抗过敏剂降低过敏的方法。

    Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof
    6.
    发明授权
    Lactic ferment comprising a particular strain of lactobacillus acidophilus and use thereof 有权
    包含嗜酸乳杆菌的特定菌株的乳酸酵素及其用途

    公开(公告)号：US06607905B1

    公开(公告)日：2003-08-19

    申请号：US09322030

    申请日：1999-05-28

    Applicant: François-Marie Luquet

    Inventor： François-Marie Luquet

    IPC: C12N120

    CPC classification number: C12R1/23 ,  A23C9/1234 ,  A23Y2220/03 ,  A61K35/747 ,  C12N1/20 ,  Y10S435/854

    Abstract: The purified strain of Lactobacillus acidophilus CNCM/I-1492 (L.a. 1492) when administered alone or in combination with another Lactobacillus acidophilus (L.a.) strain and Lactobacillus casei (L.c.) strain, has a beneficial effect on the cholesterol blood level in mammals. It also strenghtens the immune system, facilitates the absorption of nutrients and stimulates the intestinal flora. Such strains also neutralize side effects caused by antibiotics. The invention concerns the specific strain L.a. I-1492, a ferment comprising L.a. I-1492, L.a. and L.c. strains, a dairy product obtained by this ferment and a method of manufacturing the dairy product.

    Abstract translation: 当单独施用或与另一种嗜酸乳杆菌（L.a.）菌株和干酪乳杆菌（L.c.）菌株组合施用时，嗜酸乳杆菌CNCM / I-1492（L.a.1492）的纯化菌株对哺乳动物的胆固醇血液水平具有有益的作用。 它还强化免疫系统，促进营养物质的吸收和刺激肠道菌群。 这些菌株也能中和抗生素引起的副作用。 本发明涉及特定菌株L.a. I-1492，包含L.a. I-1492，L. 和L. 菌株，通过该发酵获得的乳制品和制造乳制品的方法。

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