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    Method of detecting amplification or deletion in genomic DNA Fragment
    1.
    发明授权
    Method of detecting amplification or deletion in genomic DNA Fragment 失效
    检测基因组DNA片段扩增或缺失的方法

    公开(公告)号：US08105770B2

    公开(公告)日：2012-01-31

    申请号：US12524267

    申请日：2008-01-28

    申请人： Makoto Amano ,  Naoyuki Yamamoto

    发明人： Makoto Amano ,  Naoyuki Yamamoto

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  G01N33/00 ,  B01L3/00 ,  C07H21/00 ,  C07H21/02

    CPC分类号： C12Q1/6816 ,  Y10T436/143333 ,  C12Q2565/501 ,  C12Q2563/107 ,  C12Q2545/107

    摘要： [PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity.[MEANS FOR SOLVING PROBLEMS] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-origin genomic DNA fragment to be tested with either a label represented by the following general formula (1) or another label represented by the general formula (2), and labeling a control genomic fragment that serves as a standard for detecting a difference from the test genomic DNA fragment with the other label; (b) hybridizing the labeled test genomic DNA fragment and the labeled control genomic DNA fragment each with a specimen nucleic acid containing a nucleic acid sequence for detecting the difference between the test genomic fragment and the control genomic fragment; and (c) detecting an amplification or deletion in the test genomic DNA fragment by using the fluorescent intensities thus obtained as an indication; and a kit for the above-described method which contains a nucleotide residue labeled with the label represented by the following general formula (1) and a nucleotide residue labeled with the label represented by the following general formula (2).

    摘要翻译： [问题]提供CGH方法，特别是CGH微阵列方法，使得能够以高精度和灵敏度提高检测。 用于解决问题的手段一种方法，其包括：（a）用作为待测试的细胞来源的基因组DNA片段的测试基因组DNA片段用以下通式（1）表示的标记或由 通式（2），并标记用作检测来自测试基因组DNA片段与另一个标签的差异的标准的对照基因组片段; （b）将标记的测试基因组DNA片段和标记的对照基因组DNA片段与含有用于检测测试基因组片段和对照基因组片段之间的差异的核酸序列的标本核酸杂交; 和（c）通过使用由此获得的荧光强度作为指示来检测测试基因组DNA片段中的扩增或缺失; 以及上述方法的试剂盒，其含有用下述通式（1）表示的标记标记的核苷酸残基和用下述通式（2）表示的标记标记的核苷酸残基。

    METHOD OF DETECTING AMPLIFICATION OR DELETION IN GENOMIC DNA FRAGMENT
    2.
    发明申请
    METHOD OF DETECTING AMPLIFICATION OR DELETION IN GENOMIC DNA FRAGMENT 失效
    检测基因组DNA片段放大或者删除的方法

    公开(公告)号：US20100112711A1

    公开(公告)日：2010-05-06

    申请号：US12524267

    申请日：2008-01-28

    申请人： Makoto Amano ,  Naoyuki Yamamoto

    发明人： Makoto Amano ,  Naoyuki Yamamoto

    IPC分类号： G01N33/53 ,  C07H21/00

    CPC分类号： C12Q1/6816 ,  Y10T436/143333 ,  C12Q2565/501 ,  C12Q2563/107 ,  C12Q2545/107

    摘要： [Problems] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity.[Means for Solving Problems] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-origin genomic DNA fragment to be tested with either a label represented by the following general formula (1) or another label represented by the general formula (2), and labeling a control genomic fragment that serves as a standard for detecting a difference from the test genomic DNA fragment with the other label; (b) hybridizing the labeled test genomic DNA fragment and the labeled control genomic DNA fragment each with a specimen nucleic acid containing a nucleic acid sequence for detecting the difference between the test genomic fragment and the control genomic fragment; and (c) detecting an amplification or deletion in the test genomic DNA fragment by using the fluorescent intensities thus obtained as an indication; and a kit for the above-described method which contains a nucleotide residue labeled with the label represented by the following general formula (1) and a nucleotide residue labeled with the label represented by the following general formula (2).

    摘要翻译： [问题]提供CGH方法，特别是CGH微阵列方法，使得能够以提高的精度和灵敏度提高检测。 [解决问题的方法]一种方法，其包括：（a）使用以下通式（1）表示的标记或以下述通式（1）表示的另一标记，将作为待测试的细胞来源基因组DNA片段的检测基因组DNA片段标记为 通式（2），并标记用作检测来自测试基因组DNA片段与另一个标签的差异的标准的对照基因组片段; （b）将标记的测试基因组DNA片段和标记的对照基因组DNA片段与含有用于检测测试基因组片段和对照基因组片段之间的差异的核酸序列的标本核酸杂交; 和（c）通过使用由此获得的荧光强度作为指示来检测测试基因组DNA片段中的扩增或缺失; 以及上述方法的试剂盒，其含有用下述通式（1）表示的标记标记的核苷酸残基和用下述通式（2）表示的标记标记的核苷酸残基。

    Agglutination enhancer
    3.
    发明授权
    Agglutination enhancer 有权

    公开(公告)号：US09797886B2

    公开(公告)日：2017-10-24

    申请号：US14123899

    申请日：2012-06-04

    申请人： Naoyuki Yamamoto ,  Tsutomu Masuda

    发明人： Naoyuki Yamamoto ,  Tsutomu Masuda

    IPC分类号： G01N33/53 ,  C08F220/36 ,  C08F220/60 ,  G01N33/542

    CPC分类号： G01N33/5306 ,  C08F220/36 ,  C08F220/60 ,  G01N33/542

    摘要： The purpose of the present invention is to provide an agglutination enhancer which shows superior agglutination enhancing effect to those of conventional immunoagglutination enhancers, and the present invention relates to an agglutination enhancer for an immunoagglutination measurement method which comprises a polymer having a monomer unit shown by the following general formula [1]: (Wherein R1 represents a hydrogen atom or a methyl group; R2 and R3 independently represent a methyl group or an ethyl group, respectively; X represents —NH— or an oxygen atom; n represents an integer of 1 to 6; and m represents an integer of 1 to 3), and an immunoagglutination measurement method in which, in the coexistence of the above-described agglutination enhancer for immunoagglutination measurement method, an antibody against analyte or an antigen for the analyte is brought into contact with the analyte to cause an antigen-antibody reaction.

    Surface-Mount Piezoelectric Device
    6.
    发明申请
    Surface-Mount Piezoelectric Device 有权
    表面贴装压电器件

    公开(公告)号：US20120200198A1

    公开(公告)日：2012-08-09

    申请号：US13356043

    申请日：2012-01-23

    申请人： Naoyuki Yamamoto

    发明人： Naoyuki Yamamoto

    IPC分类号： H01L41/053

    CPC分类号： H03H9/02 ,  H01L23/04 ,  H01L2924/0002 ,  H03H9/1021 ,  H03H9/15 ,  H01L2924/00

    摘要： The present invention provides piezoelectric surface mount devices in which the area of the mounting terminals is reduced, leading to reduction of manufacturing cost. A piezoelectric device comprises a package base (120) including a bottom surface having a long edge and a short edge and a pair of mounting terminals formed on respective short edges of the package base. The pair of mounting terminals are separated by a predetermined longitudinal distance (X3) and are arranged as close as possible to the longitudinal center line of the package base. The predetermined distance is sufficient to prevent electrical short when mounting the piezoelectric device onto the printed substrate. The maximum width (Z2) of each mounting terminal measured in a direction parallel with the short edges of the package base is less than one half the width of the short edge (Z1).

    摘要翻译： 本发明提供了压电表面贴装装置，其中安装端子的面积减小，导致制造成本的降低。 一种压电装置，包括：包装底座（120），包括具有长边缘和短边缘的底表面和形成在封装基座的相应短边缘上的一对安装端子。 一对安装端子以预定的纵向距离（X3）分开，并且尽可能靠近包装基座的纵向中心线。 当将压电元件安装在印刷基板上时，预定距离足以防止电气短路。 在与封装基座的短边缘平行的方向上测量的每个安装端子的最大宽度（Z2）小于短边（Z1）的宽度的一半。

    Image forming apparatus including a heater positioned between a photosensitive member and a corona charger
    8.
    发明授权
    Image forming apparatus including a heater positioned between a photosensitive member and a corona charger 失效
    图像形成装置包括位于感光构件和电晕充电器之间的加热器

    公开(公告)号：US07599642B2

    公开(公告)日：2009-10-06

    申请号：US11836983

    申请日：2007-08-10

    申请人： Masanobu Nakajima ,  Takahiro Nakase ,  Naoyuki Yamamoto

    发明人： Masanobu Nakajima ,  Takahiro Nakase ,  Naoyuki Yamamoto

    IPC分类号： G03G15/02

    CPC分类号： G03G15/0291 ,  G03G15/751 ,  G03G2215/027

    摘要： An image forming apparatus is constituted by an image bearing member; a corona charging member including a wire; a heat generating member for generating heat by energization; a shielding member, including the heat generating member, capable of shielding a portion of the corona charging member opposing to the image bearing member from the image bearing member by being moved between the corona charging member and the image bearing member; an energization control member for controlling energization of the heat generating member; and moving member for moving the shielding member to a first position at which the shielding member shields the portion and a second position retracted from the first position. When the shielding member is located at the first position, at least a part of the heat generating member is disposed between the corona charging member and the image bearing member.

    摘要翻译： 图像形成装置由图像承载部件构成; 包括线的电晕充电部件; 通过通电产生热量的发热部件; 包括所述发热元件的屏蔽部件能够通过在所述电晕充电部件和所述图像承载部件之间移动而将与所述图像承载部件相对的所述电晕充电部件的一部分从所述图像承载部件屏蔽起来; 通电控制部件，用于控制发热部件的通电; 以及用于将屏蔽构件移动到屏蔽构件遮蔽该部分的第一位置和从第一位置缩回的第二位置的移动构件。 当屏蔽构件位于第一位置时，发热构件的至少一部分设置在电晕充电构件和图像承载构件之间。

    IMAGE FORMING APPARATUS AND LINE WIDTH CORRECTION METHOD THEREFOR
    9.
    发明申请
    IMAGE FORMING APPARATUS AND LINE WIDTH CORRECTION METHOD THEREFOR 有权
    图像形成装置及其宽度校正方法

    公开(公告)号：US20080130061A1

    公开(公告)日：2008-06-05

    申请号：US11950504

    申请日：2007-12-05

    申请人： Takahiro Nakase ,  Naoyuki Yamamoto ,  Masanobu Nakajima

    发明人： Takahiro Nakase ,  Naoyuki Yamamoto ,  Masanobu Nakajima

    IPC分类号： H04N1/04

    CPC分类号： H04N1/00002 ,  H04N1/00015 ,  H04N1/00031 ,  H04N1/00045 ,  H04N1/00063 ,  H04N1/00066 ,  H04N1/00087

    摘要： This invention provides an image forming apparatus capable of outputting, without using any special device, an image which is free from changes in density and tint even upon crisscross rotation and exhibits good proportion of a small character. To accomplish this, the pulse width of a laser emission signal is controlled at 16 levels for one dot at 600 dpi, controlling an actual image in the main scanning direction. When adjusting vertical and horizontal line widths, patch data are created by rotating an anisotropic pattern through 0° and 90° (S1 in FIG. 5). Then, a reader/scanner (15) reads each patch as density data (S2 in FIG. 5). A pulse width, that is, line width correction value at which the densities of the patch patterns rotated through 0° and 90° become equal to each other is obtained (S3 in FIG. 5).

    摘要翻译： 本发明提供了一种图像形成装置，即使在使用任何特殊装置的情况下，也能够即使在十字形旋转时也能够输出密度变化和色调的图像，并且具有小的特征的较小比例。 为了实现这一点，激光发射信号的脉冲宽度以600dpi的一个点被控制在16个等级，控制主扫描方向上的实际图像。 当调整垂直和水平线宽时，通过将各向异性图案旋转0°和90°（图5中的S1）来创建贴片数据。 然后，读取器/扫描器（15）读取每个贴片作为密度数据（图5中的S 2）。 获得脉冲宽度，即，通过0°和90°旋转的贴片图案的密度彼此相等的线宽校正值（图5中的S 3）。

    Magnetic flux driven heat generation member with magnetic flux adjusting means
    10.
    发明授权
    Magnetic flux driven heat generation member with magnetic flux adjusting means 有权
    具有磁通量调节装置的磁通驱动发热件

    公开(公告)号：US07268326B2

    公开(公告)日：2007-09-11

    申请号：US11254835

    申请日：2005-10-21

    申请人： Naoyuki Yamamoto ,  Takahiro Nakase ,  Hitoshi Suzuki ,  Yasuhiro Yoshimura ,  Toshiharu Kondo

    发明人： Naoyuki Yamamoto ,  Takahiro Nakase ,  Hitoshi Suzuki ,  Yasuhiro Yoshimura ,  Toshiharu Kondo

    IPC分类号： H05B6/14 ,  G03G15/20

    CPC分类号： G03G15/2003 ,  H05B6/145

    摘要： An electromagnetic induction heating apparatus capable of uniformize a temperature distribution in a longitudinal direction of an induction heating member includes: an exciting coil (magnetic flux generation means); a fixation roller (induction heating member) for generating heat by electromagnetic induction heating by action of magnetic flux generated by the exciting coil the induction heating member heating a material to be heated through heat generation thereof by introducing the material to be heated into a heating portion and conveying the material to be heated in contact with the fixation roller; and magnetic flux shielding plate (magnetic flux adjusting means) for changing a distribution of a density of an effective magnetic flux which is the magnetic flux generated by the exciting coil and actable on the fixation roller, in a longitudinal direction of the heating portion perpendicular to a conveyance direction of the material to be heated. The magnetic flux shielding plate adjusts the effective magnetic flux so that the effective magnetic flux at a central portion of the fixation roller in the longitudinal direction of the heating portion is less than that at an end portion of the induction heating member in the longitudinal direction.

    摘要翻译： 能够使感应加热部件的长度方向的温度分布均匀化的电磁感应加热装置具备：励磁线圈（磁通产生装置）; 用于通过由励磁线圈产生的磁通量的作用的电磁感应加热产生热量的定影辊（感应加热部件），感应加热部件通过将待加热材料引入加热部分而通过其发热加热被加热材料 并输送与定影辊接触的待加热材料; 和磁通屏蔽板（磁通量调节装置），用于改变作为激励线圈产生的磁通的有效磁通密度的分布，并且能够在垂直于加热部分的加热部分的纵向方向上对定影辊施加作用 待加热材料的输送方向。 磁通屏蔽板调节有效磁通，使得定影辊在加热部分的纵向上的中心部分处的有效磁通量小于感应加热部件在纵向方向上的端部处的有效磁通量。