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    Medical implants and methods for regulating the tissue response to vascular closure devices
    1.
    发明申请
    Medical implants and methods for regulating the tissue response to vascular closure devices 审中-公开
    用于调节血管闭合装置的组织反应的医用植入物和方法

    公开(公告)号：US20050004158A1

    公开(公告)日：2005-01-06

    申请号：US10871902

    申请日：2004-06-18

    申请人： Sriram Iyer ,  Nicholas Kipshidze ,  Victor Nikolaychik ,  Gary Roubin

    发明人： Sriram Iyer ,  Nicholas Kipshidze ,  Victor Nikolaychik ,  Gary Roubin

    IPC分类号： A61B17/00 ,  A61K31/4745 ,  A61M20060101

    CPC分类号： A61L31/125 ,  A61B17/0057 ,  A61B2017/00641 ,  A61B2017/00659 ,  A61B2017/00893 ,  A61K9/7007 ,  A61K31/436 ,  A61K31/4745 ,  A61L31/044 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416

    摘要： Devices and methods for reducing, eliminating, preventing, suppressing, or treating tissue responses to hemostatic devices e.g., biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics, applied to a vascular puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis. A matrix of a material such as collagen provides a reservoir of a therapeutic agent such as rapamycin (sirolimus) and its derivatives and analogs for delivery at a tissue site at risk for vasculoproliferation, infection, inflammation, fibrosis or other tissue responses.

    摘要翻译： 公开了用于减少，消除，预防，抑制或治疗止血装置（例如生物密封剂或血管程序）的组织反应的装置和方法。 本发明采用可再吸收的生物相容性基质材料和多种治疗剂（例如抗增生剂或抗生素）的组合，应用于血管穿刺或切口以在诊断或介入性血管导管插入术后实现止血并治疗新生内膜增生和狭窄。 诸如胶原的材料的基质提供治疗剂的储库，例如雷帕霉素（西罗莫司）及其衍生物和类似物，用于在血管增生，感染，炎症，纤维化或其它组织应答风险的组织部位递送。

    Method for sealing blood vessel puncture sites
    3.
    发明授权
    Method for sealing blood vessel puncture sites 失效
    密封血管穿刺部位的方法

    公开(公告)号：US5437292A

    公开(公告)日：1995-08-01

    申请号：US155457

    申请日：1993-11-19

    申请人： Nicholas Kipshidze ,  Victor Nikolychik ,  John E. Baker

    发明人： Nicholas Kipshidze ,  Victor Nikolychik ,  John E. Baker

    IPC分类号： A61B17/00 ,  A61B17/03

    CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00495

    摘要： A method for percutaneous sealing of punctures in arterial and venous blood vessels is provided. After catheterization of any vessel or organ for diagnostic or interventional procedures or endoscopic or orthopedic procedures involving the intentional puncture and penetration of a vessel wall, or the accidental puncture of a vessel wall, separate solutions containing fibrinogen and thrombin, respectively, are introduced into the tissue surrounding the puncture site. The solutions are allowed to mix forming a semisolid gel at the time of application at the puncture site. The gel further hardens around the site to seal the puncture closed preventing the leakage of blood. Solutions of antibiotics and epinephrine as well as agents that slow clot breakdown may be included in the mixture. An apparatus for accomplishing the method is also disclosed.

    摘要翻译： 提供了一种用于动脉和静脉血管穿刺经皮密封的方法。 导管插入任何用于诊断或介入方法的血管或器官或涉及血管壁故意穿刺和穿透或者血管壁意外穿刺的内窥镜或矫形手术，分别将含有纤维蛋白原和凝血酶的分离溶液引入 围绕穿刺部位的组织。 允许溶液在穿刺部位施用时混合形成半固体凝胶。 凝胶在现场周围进一步硬化以密封穿刺，防止血液渗漏。 抗生素和肾上腺素的溶液以及减缓凝块破坏的药物可以包括在混合物中。 还公开了一种用于实现该方法的装置。

    Delivery of microparticle-conjugated drugs for inhibition of stenosis
    4.
    发明授权
    Delivery of microparticle-conjugated drugs for inhibition of stenosis 有权
    递送微粒共轭药物用于抑制狭窄

    公开(公告)号：US07754238B2

    公开(公告)日：2010-07-13

    申请号：US10190419

    申请日：2002-07-02

    申请人： Patrick L. Iversen ,  Nicholas Kipshidze

    发明人： Patrick L. Iversen ,  Nicholas Kipshidze

    IPC分类号： A61K9/127 ,  A61K9/48

    CPC分类号： A61K9/167 ,  A61K31/00 ,  A61K31/337 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/7088 ,  A61K47/6925

    摘要： Administration of a formulation comprising a antirestenotic compound conjugated to a microparticle carrier is effective to inhibit stenosis formation in a blood vessel. Such stenosis typically results, in the absence of treatment, from trauma to a vessel, such as an incision, excessive pressure, an angioplasty procedure and/or stent implantation. The antirestenotic compound is typically an antiproliferative, immunosuppressive, or antiinflammatory drug, such as rapamycin, tacrolimus, paclitaxel, dexamethasone, or an active analog or derivative, an antisense oligonucleotide, or combinations thereof. The microparticle carrier comprises a suspension of gas-filled microbubbles or biocompatible polymeric microparticles, in a pharmaceutically acceptable liquid vehicle, and is effective to deliver the conjugated therapeutic to the site of vessel injury.

    摘要翻译： 给予包含与微粒载体缀合的抗再狭窄化合物的制剂有效地抑制血管中的狭窄形成。 这种狭窄通常在没有治疗的情况下导致对血管的创伤，例如切口，过度压力，血管成形术程序和/或支架植入。 抗再狭窄化合物通常是抗增殖，免疫抑制或抗炎药物，例如雷帕霉素，他克莫司，紫杉醇，地塞米松或活性类似物或衍生物，反义寡核苷酸或其组合。 微粒载体包含气体填充的微泡或生物相容的聚合物微粒的悬浮液，在药学上可接受的液体载体中，并且有效地将缀合的治疗剂递送到血管损伤部位。

    METHODS AND COMPOSITIONS FOR THE PRODUCTION OF COMPOSITES FOR BONE IMPLANTATION
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR THE PRODUCTION OF COMPOSITES FOR BONE IMPLANTATION 审中-公开
    用于生产用于骨植入的复合材料的方法和组合物

    公开(公告)号：US20160206781A1

    公开(公告)日：2016-07-21

    申请号：US14983283

    申请日：2015-12-29

    申请人： Zurab KAKABADZE ,  David CHAKHUNASHVILI ,  Konstantine CHAKHUNASHVILI ,  Nicholas KIPSHIDZE ,  Ann KAKABADZE

    发明人： Zurab KAKABADZE ,  David CHAKHUNASHVILI ,  Konstantine CHAKHUNASHVILI ,  Nicholas KIPSHIDZE ,  Ann KAKABADZE

    IPC分类号： A61L27/36 ,  A61L27/50 ,  B65B63/08 ,  A61L27/38

    CPC分类号： A61L27/3608 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3821 ,  A61L27/3834 ,  A61L2430/02

    摘要： The invention disclosed herein relates to methods and compositions useful for the production of composites for bone implantation. The invention includes methods for production of lyophilized bone fragments seeded with lyophilized stem cells, mesenchymal stem cells, bone marrow stem cells, periosteal cells or osteocytes that are derived either from the recipient of the bone implant or from allogeneic sources. The methods of the invention comprise production of bone implant material including the steps of cutting solid bone into fragments, decellularizing the bone fragments, seeding stem cells, mesenchymal stem cells, bone marrow stem cells, periosteal cells or osteocytes onto the decellularized bone fragments and lyophilizing the complex of bone fragments and cells. The stabilized bone matrix and complex of bone and cells increases the ease of transport, storage and reconstitution of bone and cells for bone implantation.

    摘要翻译： 本文公开的本发明涉及可用于生产用于骨植入的复合材料的方法和组合物。 本发明包括用冻干的干细胞，间充质干细胞，骨髓干细胞，骨膜细胞或骨细胞接种的冻干骨碎片的方法，所述干细胞干细胞，骨髓细胞或骨细胞从骨植入物的接受者或同种异体来源衍生。 本发明的方法包括骨植入材料的生产，包括将固体骨切成碎片，将骨碎片，接种干细胞，间充质干细胞，骨髓干细胞，骨膜细胞或骨细胞脱细胞到脱细胞骨碎片上的步骤和冻干 骨碎片和细胞的复合体。 稳定的骨基质和骨和细胞的复合物增加骨和移植骨骼和细胞的运输，储存和重建的容易性。

    METHODS AND DEVICES FOR USING DRUG-ELUTING EMBOLIZATION
    10.
    发明申请
    METHODS AND DEVICES FOR USING DRUG-ELUTING EMBOLIZATION 审中-公开
    用于使用药物灌注的方法和装置

    公开(公告)号：US20080086156A1

    公开(公告)日：2008-04-10

    申请号：US11745203

    申请日：2007-05-07

    申请人： Robert Rosen ,  Nicholas Kipshidze ,  Sriram Iyer ,  Gary Roubin

    发明人： Robert Rosen ,  Nicholas Kipshidze ,  Sriram Iyer ,  Gary Roubin

    IPC分类号： A61B17/03

    CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/12131 ,  A61B17/1214 ,  A61F2002/823

    摘要： A method and system of embolizing an organ or vessel is disclosed. An embolization device such as a coil, balloon, spheres, stents or occlusive plaques is used. The embolization device has a surface, which may be coated with composition retaining material such as a polymer, bio-polymer or non-polymer based technology that allows sustained release of drug or material from drug eluting occlusive device. For example, an anti-angiogenic composition is coated on the application surface. The embolization device is then inserted in the vessel and embolization is enhanced by the composition.

    摘要翻译： 公开了栓塞器官或血管的方法和系统。 使用栓塞装置，例如线圈，球囊，球体，支架或闭塞斑块。 栓塞装置具有可以用组合物保持材料如聚合物，生物聚合物或基于非聚合物的技术涂覆的表面，其允许药物或药物从药物洗脱闭塞装置中持续释放。 例如，抗血管生成组合物涂覆在施用表面上。 然后将栓塞装置插入血管并通过组合物增强栓塞。